1.
Acta Pol Pharm
; 52(6): 477-82, 1995.
Article
in English
| MEDLINE
| ID: mdl-8960266
ABSTRACT
Hydrolysis of 1-acetoxyethyl ester of cefuroxime [I] in blood was studied in vitro and in vivo. In vitro [I] hydrolyzes to biological active cefuroxime [II] and at the same time it undergoes isomerization to isomer delta 2 of 1-acetoxyethyl ester of cefuroxime [IV] and next hydrolyzes to biological inactive isomer delta 2 of cefuroxime [V]. As a result of hydrolysis [I] in vivo only [II] is formed.