Potentiality of Nanoenzymes for Cancer Treatment and Other Diseases: Current Status and Future Challenges.

Studies from past years have observed various enzymes that are artificial, which are issued to mimic naturally occurring enzymes based on their function and structure. The nanozymes possess nanomaterials that resemble natural enzymes and are considered an innovative class. This innovative class has achieved a brilliant response from various developments and researchers owing to this unique property. In this regard, numerous nanomaterials are inspected as natural enzyme mimics for multiple types of applications, such as imaging, water treatment, therapeutics, and sensing. Nanozymes have nanomaterial properties occurring with an inheritance that provides a single substitute and multiple platforms. Nanozymes can be controlled remotely via stimuli including heat, light, magnetic field, and ultrasound. Collectively, these all can be used to increase the therapeutic as well as diagnostic efficacies. These nanozymes have major biomedical applications including cancer therapy and diagnosis, medical diagnostics, and bio sensing. We summarized and emphasized the latest progress of nanozymes, including their biomedical mechanisms and applications involving synergistic and remote control nanozymes. Finally, we cover the challenges and limitations of further improving therapeutic applications and provide a future direction for using engineered nanozymes with enhanced biomedical and diagnostic applications.

Nutritional Value of Savory Herb (Satureja hortensis L.) and Plant Response to Variable Mineral Nutrition Conditions in Various Phases of Development.

Mineral nutrition and plant ontogeny influence both the physiological balance between nutrients in a plant and determine the proper nutritional status of a plant, which is necessary to realize the yielding potential of a cultivated species. The aim of the present study was to assess the effect of nitrogen doses (0, 4, 8, 12, 16 g N·m-2) and plant development phases (the beginning and full flowering) on the content of macroelements and changes in ionic ratios occurring in the herb of the summer savory cv. 'Saturn'. The two-factor experiment was carried out in a random-block design with five replications. The mineral nitrogen nutrition applied increased the concentration of total nitrogen and its mineral forms in the plants. There was a change in ion homeostasis in the individual stages of the ontogenesis process, i.e., a higher content of P, K, Ca, and S in the initial flowering phase as well as Mg and Cl in the full flowering phase. The increase in the availability of mineral nitrogen in the soil solution caused a decrease in total sorption capacity, reducing the potential of the soil for saturation with alkaline cations.