Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 18 de 18
Filter
1.
Infection ; 39(5): 439-50, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21732120

ABSTRACT

PURPOSE: To evaluate the impact of country socioeconomic status and hospital type on device-associated healthcare-associated infections (DA-HAIs) in neonatal intensive care units (NICUs). METHODS: Data were collected on DA-HAIs from September 2003 to February 2010 on 13,251 patients in 30 NICUs in 15 countries. DA-HAIs were defined using criteria formulated by the Centers for Disease Control and Prevention. Country socioeconomic status was defined using World Bank criteria. RESULTS: Central-line-associated bloodstream infection (CLA-BSI) rates in NICU patients were significantly lower in private than academic hospitals (10.8 vs. 14.3 CLA-BSI per 1,000 catheter-days; p < 0.03), but not different in public and academic hospitals (14.6 vs. 14.3 CLA-BSI per 1,000 catheter-days; p = 0.86). NICU patient CLA-BSI rates were significantly higher in low-income countries than in lower-middle-income countries or upper-middle-income countries [37.0 vs. 11.9 (p < 0.02) vs. 17.6 (p < 0.05) CLA-BSIs per 1,000 catheter-days, respectively]. Ventilator-associated-pneumonia (VAP) rates in NICU patients were significantly higher in academic hospitals than in private or public hospitals [13.2 vs. 2.4 (p < 0.001) vs. 4.9 (p < 0.001) VAPs per 1,000 ventilator days, respectively]. Lower-middle-income countries had significantly higher VAP rates than low-income countries (11.8 vs. 3.8 per 1,000 ventilator-days; p < 0.001), but VAP rates were not different in low-income countries and upper-middle-income countries (3.8 vs. 6.7 per 1,000 ventilator-days; p = 0.57). When examined by hospital type, overall crude mortality for NICU patients without DA-HAIs was significantly higher in academic and public hospitals than in private hospitals (5.8 vs. 12.5%; p < 0.001). In contrast, NICU patient mortality among those with DA-HAIs was not different regardless of hospital type or country socioeconomic level. CONCLUSIONS: Hospital type and country socioeconomic level influence DA-HAI rates and overall mortality in developing countries.


Subject(s)
Catheter-Related Infections/mortality , Cross Infection/epidemiology , Developing Countries , Intensive Care Units, Neonatal , Pneumonia, Ventilator-Associated/mortality , Catheter-Related Infections/epidemiology , Catheter-Related Infections/microbiology , Catheterization, Central Venous/adverse effects , Catheterization, Central Venous/instrumentation , Catheterization, Central Venous/mortality , Cross Infection/blood , Cross Infection/microbiology , Cross Infection/mortality , Equipment Contamination , Hospitals, Private/classification , Hospitals, Public/classification , Hospitals, Teaching/classification , Humans , Infant, Newborn , Pneumonia, Ventilator-Associated/epidemiology , Prospective Studies , Socioeconomic Factors , Ventilators, Mechanical/adverse effects , Ventilators, Mechanical/microbiology
2.
Int J Tuberc Lung Dis ; 9(7): 771-6, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16013773

ABSTRACT

SETTING: A major university in São Paulo, Brazil, where vaccination against tuberculosis (TB) with bacille Calmette-Guerin (BCG) was routinely offered to first-year medical and nursing students. OBJECTIVES: To estimate the probability of negative tuberculin skin test (TST) results over a 4-year period following BCG revaccination, and to evaluate the effect of factors associated with reversion. DESIGN: Students were enrolled in 1997, initially given a two-step TST, and were retested annually or biannually for the duration of the study. Data on TB exposures and potential risk factors for TST negativity and reversion were collected through annual surveys. A linear mixture survival model was used to estimate the probability of negative TST results over time. RESULTS: Of 159 students, an estimated 20% had a negative TST result despite revaccination, and a further 31% reverted to negative over 4 years of follow-up. No cofactors significantly affected the probability of reversion. CONCLUSION: Overall, in the absence of reported exposure to Mycobacterium tuberculosis, 51% of students revaccinated upon entering nursing or medical school would have a negative TST result by the time they begin their internships. In this recently vaccinated population, reversion was common, suggesting that annual TST screening may remain a useful tool.


Subject(s)
BCG Vaccine , Students, Medical , Students, Nursing , Tuberculin Test , Tuberculosis/diagnosis , Adolescent , Adult , Brazil , Female , Humans , Male , Occupational Exposure , Students, Medical/statistics & numerical data , Students, Nursing/statistics & numerical data
3.
Int J Tuberc Lung Dis ; 9(12): 1335-42, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16466055

ABSTRACT

SETTING: Four general Brazilian hospitals. OBJECTIVE: To assess the occupational risk of Mycobacterium tuberculosis (TB) in participating hospitals. DESIGN: In phase one of this longitudinal study, a cross-sectional survey documented baseline tuberculin skin test (TST) positivity rates. In phase two, TST conversion rates were evaluated in participants with an initial negative two-step TST. TST conversion data were analyzed to determine risk factors for TB infection using an increase of > or = 10 mm compared to baseline TST. RESULTS: The initial TST positivity rate was 63.1%; the follow-up TST conversion rate was 10.7 per 1000 person-months (p-m). Hospital of employment, recent bacille Calmette-Guerin (BCG) vaccination, nosocomial TB exposure, and employment as a nurse were independent risk factors for TST conversion. Hospitals without TB infection control measures had higher conversion rates than those with control measures (16.0 vs. 7.8/ 1000 p-m, P < 0.001). CONCLUSIONS: This study indicates an important occupational risk of infection in health care settings with a high TB incidence. Longitudinal TST studies are a valuable tool to assess the occupational risk of TB, even in BCG-vaccinated populations, and should be used to direct limited resources for infection control.


Subject(s)
Occupational Diseases/epidemiology , Occupational Exposure/adverse effects , Personnel, Hospital , Tuberculosis/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , BCG Vaccine , Brazil , Female , Hospitals, General , Humans , Longitudinal Studies , Male , Middle Aged , Occupational Diseases/etiology , Risk Factors , Seroepidemiologic Studies , Tuberculin Test , Tuberculosis/etiology , Tuberculosis/prevention & control
4.
J Pediatr ; 139(6): 821-7, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11743507

ABSTRACT

OBJECTIVES: Patients admitted to neonatal intensive care units (NICUs) are at high risk of nosocomial infection. We conducted a national multicenter assessment of nosocomial infections in NICUs to determine the prevalence of infections, describe associated risk factors, and help focus prevention efforts. STUDY DESIGN: We conducted a point prevalence survey of nosocomial infections in 29 Pediatric Prevention Network NICUs. Patients present on the survey date were included. Data were collected on underlying diagnoses, therapeutic interventions/treatments, infections, and outcomes. RESULTS: Of the 827 patients surveyed, 94 (11.4%) had 116 NICU-acquired infections: bloodstream (52.6%), lower respiratory tract (12.9%), ear-nose-throat (8.6%), or urinary tract infections (8.6%). Infants with infections were of significantly lower birth weight (median 1006 g [range 441 to 4460 g] vs 1589 g [range 326 to 5480 g]; P <.001) and had longer median durations of stay than those without infections (88 days [range 8 to 279 days] vs 32 days [range 1 to 483 days]; P <.001). Most common pathogens were coagulase-negative staphylococci and enterococci. Patients with central intravascular catheters (relative risk = 3.81, CI 2.32-6.25; P <.001) or receiving total parenteral nutrition (relative risk = 5.72, CI 3.45-9.49; P <.001) were at greater risk of bloodstream infection. CONCLUSIONS: This study documents the high prevalence of nosocomial infections in patients in NICUs and the urgent need for more effective prevention interventions.


Subject(s)
Cross Infection/epidemiology , Health Surveys , Intensive Care Units, Neonatal/statistics & numerical data , Catheterization, Central Venous/adverse effects , Catheterization, Central Venous/statistics & numerical data , Cross Infection/etiology , Cross Infection/prevention & control , Enterococcus/isolation & purification , Female , Humans , Infant, Low Birth Weight , Infant, Newborn , Infection Control , Length of Stay , Male , Otorhinolaryngologic Diseases/epidemiology , Otorhinolaryngologic Diseases/etiology , Otorhinolaryngologic Diseases/prevention & control , Parenteral Nutrition, Total/adverse effects , Parenteral Nutrition, Total/statistics & numerical data , Prevalence , Respiratory Tract Infections/epidemiology , Respiratory Tract Infections/etiology , Respiratory Tract Infections/prevention & control , Sepsis/epidemiology , Sepsis/etiology , Sepsis/prevention & control , Staphylococcus/isolation & purification , Treatment Outcome , United States/epidemiology
5.
Clin Infect Dis ; 33(5): 589-96, 2001 Sep 01.
Article in English | MEDLINE | ID: mdl-11477527

ABSTRACT

From November 1996 through March 1997, presumptive active pulmonary tuberculosis (TB) was detected in 44 health care workers (HCWs) at a university hospital in Lima, Peru. To further assess the magnitude of the outbreak and determine risk factors for occupational Mycobacterium tuberculosis transmission, we identified HCWs in whom active pulmonary TB was diagnosed from January 1994 through January 1998, calculated rates by year and hospital work area, and conducted a tuberculin skin test (TST) survey. Thirty-six HCWs had confirmed active pulmonary TB. The rate of TB was significantly higher among the 171 HCWs employed in the laboratory than among HCWs employed in all other areas. In multivariate analysis, the only independent risk factor for HCW M. tuberculosis infection in HWCs employed in the laboratory was the use of common staff areas. Very high rates of active pulmonary TB were detected among HCWs at this hospital, and occupational acquisition in the laboratory was associated with HCW-to-HCW transmission.


Subject(s)
Health Personnel/statistics & numerical data , Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data , Tuberculosis, Pulmonary/epidemiology , Tuberculosis, Pulmonary/transmission , Adult , Female , Hospitals, University/statistics & numerical data , Humans , Infectious Disease Transmission, Patient-to-Professional/prevention & control , Laboratories, Hospital/statistics & numerical data , Male , Middle Aged , Multivariate Analysis , Mycobacterium tuberculosis/isolation & purification , Occupational Exposure/statistics & numerical data , Peru/epidemiology , Risk Factors , Tuberculin Test , Tuberculosis, Pulmonary/diagnosis
6.
Infect Control Hosp Epidemiol ; 22(12): 762-6, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11876454

ABSTRACT

OBJECTIVE: To assess the efficacy of parental education and use of parents as nursing assistants on reducing nosocomial infections. DESIGN: Prospective study. METHODS: Active surveillance for nosocomial infections was performed on two wards. On ward A, parents were educated about infection control practices and assisted nursing staff with routine tasks, so that nursing personnel could focus their efforts on procedures with higher risk of infection. Parental assistance was not sought on ward B, the comparison ward. RESULTS: From October 1990 through September 1991, 1,081 patients were admitted to wards A (470) or B (611). The over-all nosocomial infection rate was 7.1 per 100 admissions; the nosocomial infection rate was significantly higher on ward B than ward A (63/611 vs 14/470; P<.001). Multivariate analysis identified risk factors for nosocomial infection on the two wards as age <2 years (P=.01), malnutrition (P=.005), duration of hospitalization (P<.001), ward B hospitalization (P=.003), and ward cleanliness score (P=.009); the distribution of patients with these factors was similar on the two wards. CONCLUSIONS: Our data suggest that parental infection control education and recruitment to relieve nursing staff of routine low-risk procedures are economical and easily implemented measures to reduce nosocomial infections in hospitals with limited personnel resources in the developing world.


Subject(s)
Cross Infection/prevention & control , Hospitals, Pediatric , Infection Control/methods , Parents , Argentina/epidemiology , Child, Preschool , Cross Infection/epidemiology , Female , Health Surveys , Humans , Infant , Male , Multivariate Analysis , Parents/education , Risk Factors
8.
Emerg Infect Dis ; 5(1): 143-6, 1999.
Article in English | MEDLINE | ID: mdl-10081682

ABSTRACT

Early detection of vancomycin-resistant enterococci is important for preventing its spread among hospitalized patients. We surveyed the ability of eight hospital laboratories in and near Monterrey, Mexico, to detect vancomycin resistance in Enterococcus spp. and found that although laboratories can reliably detect high-level vancomycin resistance, many have difficulty detecting low-level resistance.


Subject(s)
Anti-Bacterial Agents/pharmacology , Cross Infection/microbiology , Enterococcus/drug effects , Gram-Positive Bacterial Infections/microbiology , Laboratories, Hospital/standards , Vancomycin/pharmacology , Bacteriological Techniques , Cross Infection/prevention & control , Drug Resistance, Microbial , Enterococcus/isolation & purification , Gram-Positive Bacterial Infections/prevention & control , Humans , Mexico , Microbial Sensitivity Tests , Microbiology/standards
9.
J Pediatr ; 133(5): 640-4, 1998 Nov.
Article in English | MEDLINE | ID: mdl-9821421

ABSTRACT

OBJECTIVE: To identify risk factors for polymicrobial bloodstream infections (BSIs) in neonatal intensive care unit (NICU) patients during an outbreak of BSIs. DESIGN: During an outbreak of BSIs, we conducted a retrospective cohort study, assessed NICU infection control practices and patient exposure to NICU healthcare workers (HCWs), and obtained cultures of the environment and HCW hands. PATIENTS: During the period May 3 to 7, 1996, 5 infants contracted BSIs caused by both Enterobacter cloacae and Pseudomonas aeruginosa, and one infant contracted a BSI caused by E cloacae only. For each pathogen, all isolates were identical on DNA typing. RESULTS: Infants exposed to the following were more likely than nonexposed infants to have BSI: umbilical venous catheters (6/14 vs 0/7, P = .05), total parenteral nutrition given simultaneously with a dextrose/electrolyte solution (6/12 vs 0/9, P = .02), or one HCW (5/7 vs 1/13, P = .007). Neither environmental nor HCW hand cultures yielded the outbreak pathogens. Quality control cultures of intravenous solution bags were negative. CONCLUSIONS: We speculate that a dextrose multidose vial became contaminated during manipulation or needle puncture and that successive use of this contaminated vial for multiple patients may have been responsible for BSIs. Aseptic techniques must be employed when multidose vial medications are used. Single-dose vials should be used for parenteral additives whenever possible to reduce the risk of extrinsic contamination and subsequent transmission of nosocomial pathogens.


Subject(s)
Bacteremia/transmission , Cross Infection/transmission , Drug Contamination , Enterobacter cloacae , Enterobacteriaceae Infections/transmission , Glucose/adverse effects , Pseudomonas Infections/transmission , Pseudomonas aeruginosa , Bacteremia/microbiology , Catheters, Indwelling , Cohort Studies , Cross Infection/microbiology , Drug Packaging , Enterobacteriaceae Infections/microbiology , Female , Glucose/administration & dosage , Humans , Infant, Newborn , Infusions, Intravenous , Intensive Care Units, Neonatal , Male , Pseudomonas Infections/microbiology , Puerto Rico , Retrospective Studies , Risk Factors
10.
Pediatr Infect Dis J ; 17(8): 716-22, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9726347

ABSTRACT

BACKGROUND: Acinetobacter spp. are multidrug-resistant bacteria that grow well in water and cause infections with unexplained, increased summer prevalence. In August, 1996, eight infants acquired Acinetobacter spp. bloodstream infection (A-BSI) while in a nursery in the Bahamas; three infants died and an investigation was initiated. METHODS: A case patient was defined as any newborn in the nursery during August 6 to 13, 1996, with A-BSI. To identify risk factors for A-BSI we conducted a retrospective cohort study and performed environmental cultures and air sampling using settle plates. The genetic relatedness of environmental isolates was assessed by pulsed field gel electrophoresis. RESULTS: Of 33 patients in the nursery 8 (24%) met the case definition. Patients with peripheral iv catheters were more likely to develop A-BSI (8 of 21 vs. O of 10, P < 0.05). Multivariate analysis among patients with iv catheters indicated that only exposure to one nurse was an independent risk factor for developing A-BSI (P < 0.005). Nursery settle plates were more likely to grow Acinetobacter spp. than were settle plates from other hospital areas (8 of 9 vs. 0 of 5, P < 0.005); cultures from nursery air conditioners also grew Acinetobacter spp. Environmental isolates were genetically diverse. After installation of a new air conditioner in May, 1995, A-BSIs occurred more frequently during months of increased absolute humidity or environmental dew point. CONCLUSIONS: Acinetobacter spp. may cause nosocomial BSI and death among infants during periods of polyclonal airborne dissemination; breaks in aseptic technique during i.v. medication administration may facilitate transmission from the environment to the patient. Environmental conditions that increase air conditioner condensate may predispose to airborne dissemination via contaminated aerosols and increase the risk of nosocomial A-BSI.


Subject(s)
Acinetobacter Infections/epidemiology , Acinetobacter/isolation & purification , Aerosols , Air Conditioning , Cross Infection/epidemiology , Nurseries, Hospital , Sepsis/epidemiology , Acinetobacter Infections/etiology , Acinetobacter Infections/prevention & control , Bahamas , Cohort Studies , Cross Infection/etiology , Cross Infection/prevention & control , Equipment Contamination , Female , Humans , Infant , Infant, Newborn , Male , Risk Factors , Seasons , Sepsis/etiology , Sepsis/microbiology
11.
J Infect Dis ; 178(1): 266-9, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9652452

ABSTRACT

Neisseria meningitidis is a leading cause of adult meningitis worldwide. From 5 to 14 August 1996, 8 cases of meningococcal disease occurred in Corrientes city (population 306,000) in northeastern Argentina. Those infected ranged in age from 15 to 45 years (median, 18.5). To determine risk factors for infection, a case-control study was done. Infecting isolates were serogrouped and underwent phenotyping by multilocus enzyme electrophoresis (MLEE) and pulsed-field gel electrophoresis (PFGE). Those infected were significantly more likely than those not infected to have had exposure to passive or active cigarette smoke or to have attended a particular disco. Isolates available from 6 case-patients were all serogroup C; all had identical MLEE and PFGE patterns. These data suggest that dance clubs or discos may be a focus of transmission of N. meningitidis among young people.


Subject(s)
Disease Outbreaks , Meningitis, Meningococcal/epidemiology , Meningococcal Infections/epidemiology , Neisseria meningitidis/isolation & purification , Adolescent , Adult , Argentina/epidemiology , Case-Control Studies , DNA, Bacterial , Dancing , Female , Humans , Male , Meningitis, Meningococcal/microbiology , Meningococcal Infections/microbiology , Middle Aged , Neisseria meningitidis/classification , Neisseria meningitidis/genetics , Tobacco Smoke Pollution
12.
N Engl J Med ; 338(13): 873-8, 1998 Mar 26.
Article in English | MEDLINE | ID: mdl-9516222

ABSTRACT

BACKGROUND: Hemodialysis is a common but potentially hazardous procedure. From February 17 to 20, 1996, 116 of 130 patients (89 percent) at a dialysis center (dialysis center A) in Caruaru, Brazil, had visual disturbances, nausea, and vomiting associated with hemodialysis. By March 24, 26 of the patients had died of acute liver failure. METHODS: A case patient was defined as any patient undergoing dialysis at dialysis center A or Caruaru's other dialysis center (dialysis center B) during February 1996 who had acute liver failure. To determine the risk factors for and the source of the outbreak, we conducted a cohort study of the 130 patients at dialysis center A and the 47 patients at dialysis center B, reviewed the centers' water supplies, and collected water, patients' serum, and postmortem liver tissue for microcystin assays. RESULTS: One hundred one patients (all at dialysis center A) met the case definition, and 50 died. Affected patients who died were older than those who survived (median age, 47 vs. 35 years, P<0.001). Furthermore, all 17 patients undergoing dialysis on the Tuesday-, Thursday-, and Saturday-night schedule became ill, and 13 of them (76 percent) died. Both centers received water from a nearby reservoir. However, the water supplied to dialysis center B was treated, filtered, and chlorinated, whereas the water supplied to dialysis center A was not. Microcystins produced by cyanobacteria were detected in water from the reservoir and from dialysis center A and in serum and liver tissue of case patients. CONCLUSIONS: Water used for hemodialysis can contain toxic materials, and its quality should therefore be carefully monitored.


Subject(s)
Bacterial Toxins/adverse effects , Liver Failure, Acute/etiology , Peptides, Cyclic/adverse effects , Renal Dialysis/adverse effects , Water Pollutants, Chemical/adverse effects , Water Supply , Adult , Bacterial Toxins/analysis , Cohort Studies , Cyanobacteria/metabolism , Humans , Liver/chemistry , Liver Failure, Acute/mortality , Microcystins , Middle Aged , Peptides, Cyclic/analysis , Vision Disorders/chemically induced , Vomiting/chemically induced , Water Microbiology , Water Pollutants, Chemical/analysis , Water Supply/analysis
13.
Diagn Microbiol Infect Dis ; 29(2): 107-9, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9368087

ABSTRACT

Few reports of vancomycin-resistant enterococci have appeared outside the USA. Therefore, we evaluated the ability of five laboratories in Buenos Aires, Argentina, to perform susceptibility testing using the disk diffusion method. Laboratories had difficulty identifying the low- and intermediate-level vancomycin-resistant phenotypes. This suggests that the disk diffusion method used by laboratories abroad may fail to detect some vancomycin-resistant enterococci.


Subject(s)
Anti-Bacterial Agents/pharmacology , Enterococcus/drug effects , Enterococcus/isolation & purification , Laboratories/standards , Microbial Sensitivity Tests/methods , Vancomycin/pharmacology , Argentina , Bacteriological Techniques/standards , Culture Media , Drug Resistance, Microbial , Humans , Sensitivity and Specificity
14.
J Pediatr ; 129(5): 711-7, 1996 Nov.
Article in English | MEDLINE | ID: mdl-8917238

ABSTRACT

OBJECTIVES: To determine the cause of increased central venous catheter-associated (CVC) bloodstream infection (BSI) rates in a cohort of pediatric hematology /oncology patients receiving home health care (HHC). METHODS: A retrospective cohort study of hematology/oncology patients with CVCs receiving HHC from January 1992 through November 1994. RESULTS: Of 182 patients with CVCs identified during the study period, 58 (32%) acquired 90 BSIs during 75,085 CVC days. BSI rates increased significantly from 1992 through 1994 (0.8 vs 1.0 vs 1.7 BSIs per 1000 CVC days; p < 0.005). Known risk factors, including catheter type, patient age less than 5 years, sex, or diagnosis, were not associated with increased BSI rates. After introduction of needleless devices for CVC access to the HHC regimen in May 1993, BSI rates increased 80% (from 0.81 to 1.46 BSIs/1000 CVC days, relative risk 1.8; p < 0.02). The only other significant risk factor was the race of the patient. White children had the lowest BSI rate before and after needleless-device introduction (0.4 vs 0.9 BSIs/1000 CVC days; p > 0.1), whereas black patients had the highest, unaffected by the introduction of these devices (2.5 BSIs/1000 CVC days). Both Hispanic (0.5 vs 1.6 BSIs/1000 CVC days) and Asian-American children's (0.4 vs 1.5 BSIs/1000 CVC days) BSI rates increased threefold and fourfold after the introduction of needleless devices. CONCLUSIONS: Our data suggest that pediatric hematology/oncology patients receiving HHC via needleless devices may have an increased risk of BSIs, and this risk may vary by race. We hypothesize that prevention of BSIs may require consideration of cultural, ethnic, and language differences when parents are trained to provide care for their children with CVCs in the home.


Subject(s)
Catheterization, Central Venous/adverse effects , Racial Groups , Sepsis/etiology , Adolescent , Adult , Catheters, Indwelling/adverse effects , Child , Child, Preschool , Female , Hematologic Diseases/drug therapy , Humans , Infant , Male , Needles , Neoplasms/drug therapy , Retrospective Studies , Risk Factors , Severity of Illness Index , Time Factors
15.
J Pediatr ; 124(5 Pt 1): 694-702, 1994 May.
Article in English | MEDLINE | ID: mdl-7513755

ABSTRACT

To assess the risk of acquisition of Pseudomonas cepacia by person-to-person transmission at cystic fibrosis summer camps, we conducted in 1990 a study at three camps attended by patients with cystic fibrosis who had P. cepacia infection and patients without P. cepacia infection but who were considered susceptible to infection. We obtained sputum or throat cultures from campers on their arrival at, weekly during, at the end of, and 14 to 30 days after camp. We compared the incidence of sputum conversion of patients at camp with that of patients outside camp by culturing specimens from noncamper control subjects with cystic fibrosis who were known not to be infected < or = 2 weeks before and 4 to 6 weeks after camp. We also determined the risk factors for P. cepacia acquisition by determining the relative risk of acquisition between campers who were exposed versus campers who were not exposed to campers known to be infected or to potential environmental sources of P. cepacia at camp. The ribotype of P. cepacia isolates from campers with sputum conversion was compared with that of isolates from other campers and from an environmental source. The cumulative incidence of sputum conversion during the study period was 6.1% (11/181) among campers compared with no incidence (0/92) among noncampers (p = 0.02, Fisher Exact Test). The incidence of sputum conversion at camp varied according to the prevalence of campers with known infection (p < 0.001, chi-square test for trend). The rate of sputum conversion was higher in the camp with longer duration (relative risk = 12.0; 95% confidence interval = 2.7 to 53.5). Ribotyping showed that P. cepacia isolates from all 11 campers with sputum conversion were identical or similar (1 to 2 band difference) to isolates of other P. cepacia-infected campers including co-converters. These results suggest that P. cepacia can be acquired by patients with cystic fibrosis who are attending summer camp for such patients, possibly through person-to-person transmission, and that the risk increases with the prevalence of P. cepacia-infected campers and the duration of camp.


Subject(s)
Burkholderia cepacia , Camping , Cystic Fibrosis/complications , Pseudomonas Infections/transmission , Adolescent , Adult , Bacterial Typing Techniques , Burkholderia cepacia/classification , Burkholderia cepacia/genetics , Burkholderia cepacia/isolation & purification , Case-Control Studies , Child , DNA, Bacterial/analysis , Female , Humans , Incidence , Male , Polymorphism, Restriction Fragment Length , Pseudomonas Infections/epidemiology , Pseudomonas Infections/microbiology , Risk Factors , Sputum/microbiology
16.
JAMA ; 267(19): 2632-4, 1992 May 20.
Article in English | MEDLINE | ID: mdl-1573751

ABSTRACT

OBJECTIVE: To assess nosocomial transmission of tuberculosis (TB). DESIGN: A historical cohort study of hospitalized patients with the human immunodeficiency virus (HIV) and a purified protein derivative (PPD) tuberculin skin test survey of health care workers (HCWs). SETTING: A large public teaching hospital in San Juan, Puerto Rico. PATIENTS: For the cohort study, a case patient was defined as any patient in the HIV unit at the hospital who developed culture-positive TB from 31 days or more after admission through December 31, 1989. For the PPD survey, of 1420 HCWs from the hospital, 908 agreed to participate and had sufficient data for analysis. MAIN OUTCOME MEASURES: For the cohort study, to compare the risk of developing active TB among patients who were exposed to hospital roommates with infectious TB and the risk among nonexposed patients. For the HCW PPD survey, to determine the prevalence of and risk factors for tuberculous infection. RESULTS: Eight of 48 (9.7/10,000 person-days) exposed case patients vs four of 192 (0.8/10,000 person-days) nonexposed case patients developed active TB (relative risk [RR] = 11; 95% confidence interval [CI], 2.3, 50.3). Positive PPDs (greater than or equal to 10 mm of induration) in HCWs were associated with older age (P = .0001) and with history of community TB exposure (P = .0002). In a multivariable logistic model that adjusted for these variables, HIV unit nurses (nine of 19) and nurses in the internal medicine ward (45 of 90) had a higher proportion of positive PPDs than the reference group (clerical personnel on other floors: 35 of 188, P = .0005). CONCLUSIONS: These data suggest that patient-to-patient transmission of TB in HIV units can occur and that HCWs are at risk of acquiring TB infection.


Subject(s)
Cross Infection/transmission , HIV Infections/complications , Personnel, Hospital , Tuberculosis/transmission , Adolescent , Adult , Cohort Studies , Hospital Units , Humans , Middle Aged , Mycobacterium tuberculosis/isolation & purification , Occupational Diseases/epidemiology , Occupational Diseases/etiology , Prevalence , Puerto Rico , Risk Factors , Tuberculin , Tuberculosis/diagnosis , Tuberculosis/epidemiology
17.
J Pediatr ; 118(5): 693-7, 1991 May.
Article in English | MEDLINE | ID: mdl-1902255

ABSTRACT

Because the federal government's diagnosis-related group (DRG) classification system for prospective payment has not been widely applied to hospitalized pediatric patients, we analyzed the effectiveness of one DRG category (central nervous system infections) for a single year at a medium-sized children's hospital to control for patients' severity of illness and for hospital reimbursement. Several independent measures of severity of illness (length of stay, duration of fever, Physiologic Severity Index) showed that patients with bacterial meningitis and those with encephalitis (DRG 20) were more ill than those with aseptic meningitis (DRG 21) (p less than 0.001 for each measure). Cost analysis revealed that the hospital was only partially reimbursed for its charges (shortfall of $95,547) and that patients with Medicaid or no insurance accounted for 22% of discharges but 88% of losses. Reimbursement by DRG would have increased payment for DRG 21 but decreased that for DRG 20. If DRGs were applied to pediatric central nervous system infections and used in a prospective payment system, they would accurately predict disease severity between but not within groups, and significant financial losses for children's hospitals would still occur.


Subject(s)
Central Nervous System Diseases/economics , Diagnosis-Related Groups/economics , Infections/economics , Prospective Payment System/economics , Severity of Illness Index , Central Nervous System Diseases/diagnosis , Child , Costs and Cost Analysis/economics , Costs and Cost Analysis/statistics & numerical data , Diagnosis-Related Groups/statistics & numerical data , Encephalitis/diagnosis , Encephalitis/economics , Georgia , Humans , Infections/diagnosis , Length of Stay/economics , Length of Stay/statistics & numerical data , Meningitis/diagnosis , Meningitis/economics , Meningitis, Aseptic/diagnosis , Meningitis, Aseptic/economics , Prospective Payment System/statistics & numerical data
SELECTION OF CITATIONS
SEARCH DETAIL