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Arch Microbiol ; 109(1-2): 65-74, 1976 Aug.
Article in German | MEDLINE | ID: mdl-962473

ABSTRACT

Streptomyces flaveolus, strain Tü 1240 produces besides Tirandamycin A, a hitherto unknown antibiotic, which is closely related to Tirandamycin A. The new antibiotic Tirandamycin B contains one additional hydroxylgroup. Both antibiotics exhibit a similar antimicrobial spectrum and they seem to have the same mechanism of action. According to the data obtained from mass spectrometry, 13C-and 1H-NMR spectra formula II could be deduced for Tirandamycin B.


Subject(s)
Anti-Bacterial Agents , Aminoglycosides , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Chemical Phenomena , Chemistry, Physical , DNA-Directed RNA Polymerases/antagonists & inhibitors , Fermentation , Microbial Sensitivity Tests , Molecular Conformation , Pyrrolidinones/biosynthesis , Pyrrolidinones/pharmacology , RNA, Bacterial/biosynthesis , Streptomyces/metabolism
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