Subject(s)
Autoantibodies/isolation & purification , Kidney Tubules, Proximal/immunology , Anemia/immunology , Animals , Antibodies, Antinuclear/isolation & purification , Collagen Diseases/immunology , Diabetes Mellitus/immunology , Digestive System Diseases/immunology , Female , Fluorescent Antibody Technique , Humans , Hyperlipidemias/immunology , Male , Mitochondria/immunology , Muscle, Smooth/immunology , Myocarditis/immunology , Neoplasms/immunology , Nephritis/immunology , Pneumonia/immunology , Rats , Skin Diseases/immunologySubject(s)
Hepatitis B/drug therapy , Insulin/therapeutic use , Acute Disease , Adult , Drug Evaluation , Drug Therapy, Combination , Female , Hepatitis B/pathology , Hepatitis, Alcoholic/drug therapy , Hepatitis, Alcoholic/pathology , Humans , Liver Diseases/drug therapy , Liver Diseases/pathology , Liver Regeneration/drug effects , Male , Middle AgedSubject(s)
Carrier State/immunology , Hepatitis B/genetics , Adolescent , Adult , Aged , Child , Child, Preschool , Chronic Disease , Hepatitis B/immunology , Hepatitis B Surface Antigens/immunology , Humans , Infant , Middle Aged , Time FactorsABSTRACT
PIP: 7 individual cases of hepatocellular damage caused by the use of oral hormonal contraceptives are examined. 3 different morphological patterns of damage were observed: reactive hepatitis, intrahepatic cholestasis, and subacute hepatitis. Discussion of the pathenogenesis of this damage revolves around the theory of competitive effect of sex hormones on the metabolism and transport of bilirubin, the theory of hypersensitivity, and theoretical toxic actions of contraceptive hormones. The reversibility of hepatocellular damage in 3 cases in the form of gestational hepatosis perhaps advocates the theory of hypersensitivity to endogenous and exogenous hormones. 1 case of subacute hepatitis had a lethal outcome, which suggests the possibility of direct toxic effects of hormonal contraceptives.^ieng