Comparison of Low-Dose Promethazine and Dexamethasone against Ondansetron Monotherapy Given as Antiemetic Prophylaxis during Myomectomy Under Spinal Anesthesia: A Randomized Clinical Trial.

Background: Postoperative nausea and vomiting (PONV) prophylaxis is still inadequate for a significant proportion of women undergoing myomectomy under spinal anesthesia; and it substantially decreases patient's quality of postoperative recovery. Current protocol and practice favor the use of combination therapy like promethazine/dexamethasone for PONV prophylaxis with minimal side effects and cost advantages in low-resource climes. Methodology. Seventy American Society of Anesthesiologist (ASA) class I or II women aged 21-65 years scheduled for myomectomy were recruited and randomized into group A (promethazine/dexamethasone group) and group B (ondansetron group). Myomectomy was performed on each patient using spinal anesthesia. After induction of spinal anesthesia, patients in group A received intravenous promethazine 12.5 mg and dexamethasone 8 mg while group B received intravenous ondansetron 8 mg. Early (0-3 h) and late (4-24 h) PONV was assessed using the numerical scoring scale. Results: Data analysis was done using SPSS version 20. Postoperatively, there was no significant difference in the incidence of early ansd late PONV (p value >0.05) despite the higher incidents in the ondansetron group. The proportion of patients who required rescue antiemetics was more in the ondansetron group when compared with the promethazine/dexamethasone, with minimal and statistically insignificant side effects in both groups. There was significant patient satisfaction in both groups. Conclusion: The study shows that the combination of low-dose promethazine and dexamethasone is comparable to ondansetron when used as prophylaxis for PONV with cost benefits in low-resource environments.

Nigerian surgical outcomes - Report of a 7-day prospective cohort study and external validation of the African surgical outcomes study surgical risk calculator.

BACKGROUND: Surgical outcomes study for individual nations remains important because of international differences in patterns of surgical disease. We aimed to contribute to data on post-operative complications, critical care admissions and mortality following elective surgery in Nigeria and also validate the African Surgical Outcomes Study (ASOS) surgical risk calculator in our adult patient cohort. MATERIALS AND METHODS: We conducted a 7-day, national prospective observational cohort study in consented consecutive patients undergoing elective surgery with a planned overnight hospital stay following elective surgery during a seven-day study period. The outcome measures were in-hospital postoperative complications, critical care admissions and in-hospital mortality censored at 30 days. Also, we identified variables which significantly contributed to higher ASOS surgical risk score. External validation was performed using area under the receiver operating characteristic curve (ROC) for discrimination assessment and Hosmer-Lemeshow test for calibration. RESULTS: A total of 1,425 patients from 79 hospitals participated in the study. Postoperative complications occurred in 264(18.5%, 95% CI 16.6-20.6), 20(7.6%) of whom were admitted into the ICU and 16(6.0%) did not survive. Total ICU admission was 57 (4%), with mortality rate of 23.5% following planned admission and overall in-hospital death was 22(1.5%, 95% CI 0.9-2.2). All prognostic factors in the ASOS risk calculator were significantly associated with higher ASOS score and the scoring system showed moderate discrimination (0⋅73, 95% CI 0.62-0.83). Hosmer-Lemeshow χ2 test revealed scale was well calibrated in the validation cohort. CONCLUSION: NiSOS validates the findings of ASOS and the ability of the ASOS surgical risk calculator to predict risk of developing severe postoperative complications and mortality. We identified failure-to-rescue as a problem in Nigeria. Furthermore, this study has provided policy makers with benchmarks that can be used to monitor programmes aimed at reducing the morbidity and mortality after elective surgery. We recommend the adoption of the ASOS surgical risk calculator as a tool for risk stratification preoperatively for elective surgery.

Pre-hospital care of road traffic accident victims in the Niger Delta: a private initiative and experience.

This is a review of pre-hospital care of road traffic accident (RTA) victims in the Niger Delta covering the highway linking Benin to Warri in Delta State, Nigeria, from January to December (2017). The non-availability of these services in the South South Nigeria prompted this initiative. Ambulance services with technicians and doctors attended the patients when accidents occurred. This was done in collaboration with the Nigeria Red Cross, Police, Army, and Road safety patrol teams. The information from the patrol team through dedicated lines initiated the emergency response. Response time was an average of 10-30 minutes. A major benefit of this initiative is early commencement of resuscitation and prevention of secondary injuries. A total of 70 RTA victims were salvaged from the accident scene by the Red Cross Society in 2017. A total of 29 RTA patients were salvaged through this initiative in 2017, in Delta State, Nigeria. The main challenges of this effort were delayed communication, insufficient ambulance manpower, and limited funding. Government involvement in public enlightenment, training paramedics, and provision of ambulance services to reduce deaths on our highways is needed.

An urgent necessity under general anaesthesia--surgical gloves made into re-breathing bag.

Anaesthetic practice in resource-poor countries often requires a lot of improvisation on the part of practitioners in order to meet the needs of patients. Disposables in a low-resource environment are usually stretched beyond the manufacturer's recommended life span. While anaesthetizing a six-month-old baby with cleft lip, the reservoir bag was accidentally torn and was replaced with latex surgical gloves. In the absence of a spare bag this replacement served the patient throughout the period of surgery.

Pericardiectomy in post-traumatic suppurative constrictive pericarditis: case report.

A 13-year-old male was seen at the Hospital with a 5-months history of right chest swelling, pain and recurrent fever and breathlessness on mild exertion. There was a history of gunshot to his chest two and half years before presentation.On admission he was febrile with a temperature of 39 degrees C. The chest wall swelling measuring 6 cm/6 cm was tender and fluctuant and needle aspiration yielded purulent fluids. His blood pressure and pulse were 110/60 mmHg (14.6/8 Kpa) and 100 per minute respectively. The chest radiograph showed massive cardiomegaly with pellets lodging in the right 5(th )costosternal joint. Echocardiography confirmed massive pericardial effusion. The electrocardiogram showed sinus rhythm and low voltage of QRS complexes without chamber enlargement. A diagnosis of constrictive pericarditis with purulent pericardial effusion secondary to foreign body abscess was made.His clinical picture improved after an initial incision and drainage of the right anterior chest wall abscess under ketamine intravenous anaesthesia. Two weeks after, he had pericardiectomy under general anaesthesia using a nitrous/oxygen/halothane relaxant technique which was uneventful.

Anaesthetic management of post-burn contractures, a recurrent challenge from oil pipeline vandalization in Nigeria: a case report.

A 13 year- old girl presented to the department with sternomental contractures as a result of facial burns from kerosene explosion. Difficult airway was envisaged. Over the period of time she developed sub-mental contracture with keloids; and was scheduled for release of contractures and flap closure.Anaesthesia was induced with halothane and 100% oxygen. A size 3 laryngeal mask airway (LMA) was inserted and anaesthesia maintained with oxygen/nitrous oxide/halothane/muscle relaxant technique. The successful placement of LMA at 2(nd )attempt was aided by a surgical incision on the submental contracture. Blood loss was 600 mls and a unit of packed red blood cells was transfused. She made full recovery and was discharged home after 1 month.

Use of tourniquet in a sickle cell patient for sequestrectomy and saucerisation: a case report.

A 25 yr old 60 kg haemoglobin SS male presented with a 3 year history of a discharging sinus in the left upper arm. His last crisis was ten years earlier; while his stable haemoglobin concentration was 10 g/dl.Examination revealed healthy looking, well hydrated man. He had left upper arm chronic osteomyelitis which was diagnosed radiologically. He was scheduled for an elective saucerization and sequestrectomy. Tourniquet was applied to reduce blood loss and maintain a relatively bloodless field at surgery; and nitrous oxide/oxygen/halothane relaxant technique of anaesthesia was adopted.No perioperative problems were encountered and the patient made remarkable improvement and was discharged home. At post surgical review a few weeks after, he was stable and well.