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2.
Urology ; 40(1): 7-8, 1992 Jul.
Article in English | MEDLINE | ID: mdl-1320303

ABSTRACT

In a prospective study, 63 patients with histopathologically proved Stage III nonseminomatous testicular cancer (NSTC) were analyzed to predict the need for surgical resection of residual masses after cis-platinum-based chemotherapy. Of these 63 patients, 23 (37%) had residual masses after cis-platinum-based chemotherapy requiring surgical resection. Of the 23 patients undergoing surgical resections for their residual masses, 18 patients (78%) had matured teratoma, 3 (13%) had fibrosis with necrosis, and 2 (9%) had residual tumors. Twenty of the 23 (91%) patients with residual disease had either teratomatous elements in primary tumor or bulky metastatic disease at the time of initial chemotherapy. Two patients had incomplete resection of the metastatic disease containing teratoma and required additional resection of recurrent growing matured teratomas. We conclude that teratomatous elements in primary tumor having also bulky metastatic disease are strong predictors of residual disease after initial chemotherapy requiring surgery (21 of 23 or 91%).


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Neoplasms, Germ Cell and Embryonal/surgery , Teratoma/surgery , Testicular Neoplasms/surgery , Chemotherapy, Adjuvant , Cisplatin/administration & dosage , Humans , Male , Neoplasms, Germ Cell and Embryonal/drug therapy , Neoplasms, Germ Cell and Embryonal/epidemiology , Prognosis , Prospective Studies , Risk Factors , Teratoma/drug therapy , Teratoma/epidemiology , Testicular Neoplasms/drug therapy , Testicular Neoplasms/epidemiology
4.
Urology ; 39(3): 207-10, 1992 Mar.
Article in English | MEDLINE | ID: mdl-1546411

ABSTRACT

Flow cytometric DNA analysis and ABO(H) cell surface antigen expression were studied in 46 patients with cystectomies for carcinoma of bilharzial bladder. The most significant prognostic indicators were the DNA index and the status of the pelvic lymph nodes at operation. Diploid tumors were associated with a low metastatic potential (7.7%) and a better five-year survival (54%) in contrast to aneuploid cases that had a higher metastatic potential (45.5%) and a low five-year survival (21%). The ABO(H) isoantigen status did not correlate with pathologic parameters or the clinical course of these invasive bilharzial bladder tumors as was previously reported.


Subject(s)
ABO Blood-Group System/immunology , Adenocarcinoma/chemistry , Carcinoma, Squamous Cell/chemistry , Carcinoma, Transitional Cell/chemistry , DNA, Neoplasm/analysis , Isoantigens/analysis , Urinary Bladder Neoplasms/chemistry , Adenocarcinoma/etiology , Adenocarcinoma/mortality , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/mortality , Carcinoma, Transitional Cell/etiology , Carcinoma, Transitional Cell/mortality , Flow Cytometry , Humans , Ploidies , Prognosis , Schistosomiasis haematobia/complications , Survival Analysis , Urinary Bladder Neoplasms/etiology , Urinary Bladder Neoplasms/mortality
5.
Eur Urol ; 21 Suppl 1: 1-4, 1992.
Article in English | MEDLINE | ID: mdl-1425830

ABSTRACT

We have studied the role of combined measurements of tumor collagenase-stimulating factor (TCSF) and tumor autocrine motility factor (TAMF) in 83 first morning voids and 24-hour specimens in patients with bladder and renal cancer and control subjects. TCSF and TAMF were measured by immunoabsorption assay and motility test utilizing modified Boyden chamber. The mean concentrations of urinary TCSF and TAMF from cancer patients (n = 32) were 4- to 5-fold higher than those from benign conditions (n = 70). We compared TCSF and TAMF utilizing motility test in first morning voids (n = 18) and 24-hour urinary samples (n = 19). TCSF and TAMF were almost identical in terms of eluted proteins from morning voids and 24-hour urine samples. Invasive bladder cancer (n = 12) showed a significantly higher correlation (r = 0.9 and p = 0.0001) between motility response and urinary concentration of TCSF and TAMF. We have also localized these two glycoproteins in cell membranes and cytoplasms of cancer cell.


Subject(s)
Antigens, CD , Antigens, Neoplasm , Biomarkers, Tumor/analysis , Carcinoma, Squamous Cell/urine , Carcinoma, Transitional Cell/urine , Glucose-6-Phosphate Isomerase/analysis , Membrane Glycoproteins/metabolism , Urinary Bladder Neoplasms/urine , Basigin , Carcinoma, Squamous Cell/chemistry , Carcinoma, Squamous Cell/pathology , Carcinoma, Transitional Cell/chemistry , Carcinoma, Transitional Cell/pathology , Enzyme Activation , Humans , Neoplasm Invasiveness , Time Factors , Urinary Bladder Neoplasms/chemistry , Urinary Bladder Neoplasms/pathology
6.
Eur Urol ; 21 Suppl 1: 34-6, 1992.
Article in English | MEDLINE | ID: mdl-1385131

ABSTRACT

Detection of serum and cellular AFP and hCG has made a significant contribution in understanding and management of testicular cancer. It is essential to remember the following events in utilizing these markers: (1) Histologic diagnosis of seminoma, but AFP is elevated. There is usually an element of choriocarcinoma. (2) Histologic diagnosis of seminoma and highly elevated hCG greater than 100 ng/ml has usually an element of choriocarcinoma. (3) Histologic diagnosis of choriocarcinoma with an elevated serum AFP. There is usually an element of embryonal carcinoma. (4) Pathologic stage I nonseminomatous testicular cancer with elevated serum markers is either stage II or stage III. (5) In a recent study of 23 patients undergoing resection of residual nonseminomatous testicular cancer after intensive chemotherapy, 21 had either teratoma in primary tumor or bulky metastatic disease. The markers were normalized after chemotherapy and prior to resection. (6) Although normalization of these markers after chemotherapy indicates effective therapeutic response, one should look of residual tumor utilizing radiologic investigations.


Subject(s)
Biomarkers, Tumor/analysis , Chorionic Gonadotropin/analysis , Dysgerminoma/diagnosis , Testicular Neoplasms/diagnosis , alpha-Fetoproteins/analysis , Dysgerminoma/blood , Dysgerminoma/chemistry , Humans , Male , Testicular Neoplasms/blood , Testicular Neoplasms/chemistry
10.
Int J Epidemiol ; 19(4): 825-31, 1990 Dec.
Article in English | MEDLINE | ID: mdl-1964675

ABSTRACT

A case-control study of 271 testicular cancer cases aged 18-42, including 60 seminomas and 206 other germinal cell tumours, and 259 controls was carried out to study the association between occupation and testicular cancer risk. Study subjects were identified at three medical centres, two of which treat military personnel. Controls were men diagnosed with a cancer other than of the genital tract. Associations were identified between professional employment (administrators, teachers and other professionals) and risk for testicular seminoma, OR = 2.8 (95% Cl: 1.4-5.4) and between employment in production work and risk for other germinal cell tumours, OR = 1.8 (95% Cl: 1.1-2.7). No specific occupations within these broad groups were responsible for observed increases. Self-reported exposure to microwave and other radio waves was associated with an excess risk for both seminomas and other germinal cell tumours. However, an assessment of radio wave exposure based on job title did not support this finding. Although testicular cancer has been increasing in recent decades among young males, occupational factors did not appear to account for a substantial proportion of testicular cancer occurrence in the population studied.


Subject(s)
Dysgerminoma/etiology , Occupational Exposure , Testicular Neoplasms/etiology , Adolescent , Adult , Age Factors , Case-Control Studies , Dysgerminoma/epidemiology , Humans , Male , Military Personnel , Neoplasms, Germ Cell and Embryonal/epidemiology , Neoplasms, Germ Cell and Embryonal/etiology , Odds Ratio , Risk Factors , Testicular Neoplasms/epidemiology , United States/epidemiology
11.
J Occup Med ; 32(9): 846-53, 1990 Sep.
Article in English | MEDLINE | ID: mdl-2127427

ABSTRACT

Over the past several years, many tumor markers, including cell surface antigens, T-antigen, ras p55, and ras p52 proteins, have been studied as potential tumor markers of bladder cancer. The lack of specificity and inconsistency of these markers led us to develop a new method for studying the urinary excretion of autocrine motility factor (uAMF) and tumor cell collagenase stimulating factor (TCSF) in 24-hour and first morning voided specimens. AMF is a glycoprotein secreted by the malignant cells and is responsible for cell locomotion, a key event in invasion and metastases of the malignant cells. TCSF is a membrane bound glycoprotein of tumor cells that stimulates fibroblast collagenase production. We have utilized an enzyme-linked immunoabsorption assay to detect the levels of uAMF and TCSF in urine samples collected from normal volunteers, patients with benign diseases, and patients with bladder cancer. Our data indicate that urinary concentrations of uAMF and TCSF are elevated in patients with bladder cancer. Furthermore, the levels of uAMF and TCSF are more elevated in invasive tumors as compared with benign counterparts. We have localized uAMF and TCSF in bladder cancer cells, utilizing immunohistologic techniques.


Subject(s)
Antigens, CD , Antigens, Neoplasm , Biomarkers, Tumor/urine , Membrane Glycoproteins/urine , Neoplasm Proteins/urine , Urologic Neoplasms/diagnosis , Basigin , Enzyme-Linked Immunosorbent Assay , Glucose-6-Phosphate Isomerase , Humans , Regression Analysis , Single-Blind Method
14.
Urology ; 34(6): 357-9, 1989 Dec.
Article in English | MEDLINE | ID: mdl-2595881

ABSTRACT

Over the past several years, we have utilized methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) as definitive, neoadjuvant, and adjuvant therapy for various stages of transitional cell carcinoma with reduced toxicities. Currently, there is little information concerning the histopathologic changes after M-VAC therapy. We report on the histopathologic changes of bladder transitional cell carcinoma following M-VAC chemotherapy in our protocol for treatment of bladder cancer. The main histopathologic findings after M-VAC therapy are squamous metaplasia, necrosis, fibrosis, and persistent transitional cell carcinoma. In 2 cases, there were persistent adenocarcinoma and squamous cell carcinoma. The importance of these observations in terms of diagnostic and therapeutic implications is reviewed.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Transitional Cell/pathology , Urinary Bladder Neoplasms/pathology , Adenocarcinoma/drug therapy , Adenocarcinoma/pathology , Adult , Aged , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/pathology , Carcinoma, Transitional Cell/drug therapy , Cisplatin/administration & dosage , Doxorubicin/administration & dosage , Fibrosis , Humans , Metaplasia , Methotrexate/administration & dosage , Middle Aged , Neoplasm Staging , Prospective Studies , Urinary Bladder Neoplasms/drug therapy , Vinblastine/administration & dosage
19.
J Urol ; 140(2): 381-2, 1988 Aug.
Article in English | MEDLINE | ID: mdl-3398144
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