ABSTRACT
Sustainable and water-wise cities maintain an eco-friendly urban hydrological cycle (UHC). Regrettably, the UHC of Pakistani cities is not consistently eco-friendly. Pakistan is situated within the influential area of the world's largest monsoon weather system. Cities like Lahore face simultaneous vulnerabilities to urban flooding and water scarcity due to extreme climate change events. Therefore, Pakistan's urban areas necessitate Urban Water Infrastructural Transformation (UWIT), achievable only after identifying suitable Rainwater and Stormwater Harvesting Potential Sites (RSWHPS) in Lahore. Hence, we conducted spatial analysis to pinpoint these RSWHPS within Lahore city for 2020, utilizing the World View Water Index (WV-WI). The results indicate 85.54 km2 of available areas for rain and stormwater harvesting potential during monsoon rains in Lahore. The area with the highest potential in Lahore is Wagha town, featuring 19.96 km2 of stagnant water. Additionally, RSWHPS is classified into four categories based on potential: high, medium, low, and water bodies in Lahore. Urgent transformation is required for the identified storm and rainwater harvesting sites. Consequently, this study will serve as a snapshot for policymakers to systematically address water shortage and urban flooding, making Lahore's hydrological cycle eco-friendly and sustainable.
Subject(s)
Water Supply , Water , Pakistan , Weather , Rain , Cities , Spatial Analysis , Conservation of Natural Resources/methodsABSTRACT
Background: Hepatitis C, caused by the Hepatitis C Virus (HCV), is the second most common form of viral hepatitis. The geographical distribution of HCV genotypes can be quite complex, making it challenging to ascertain the most prevalent genotype in a specific area. Methods: To address this, a review was conducted to determine the prevalence of HCV genotypes across various provinces and as a whole in Pakistan. The scientific literature regarding the prevalence, distribution, genotyping, and epidemiology of HCV was gathered from published articles spanning the years 1996-2020. Results: Genotype 1 accounted for 5.1% of the patients, with its predominant subtype being 1a at 4.38%. The frequencies of its other subtypes, 1b and 1c, were observed to be 1.0% and 0.31% respectively. Genotype 2 had a frequency of 2.66%, with the most widely distributed subtype being 2a at 2.11% of the patients. Its other subtypes, 2b and 2c, had frequencies of 0.17% and 0.36% respectively. The most prevalent genotype among all isolates was 3 (65.35%), with the most frequent subtype being 3a (55.15%), followed by 3b (7.18%). The prevalence of genotypes 4, 5, and 6 were scarce in Pakistan, with frequencies of 0.97%, 0.08%, and 0.32% respectively. The prevalence of untypeable and mixed genotypes was 21.34% and 3.53% respectively. Estimating genotypes proves to be a productive method in assisting with the duration and selection of antiviral treatment. Different HCV genotypes can exhibit variations in their response to specific antiviral treatments. Different genotypes may have distinct natural histories, including variations in disease progression and severity. Some genotypes may lead to more rapid liver damage, while others progress more slowly. Conclusions: This information can guide screening and testing strategies, helping to identify individuals at higher risk of developing severe complications. Studying the distribution of HCV genotypes in a population can provide valuable insights into the transmission dynamics of the virus.
