ABSTRACT
Introduction Gastric electrical stimulation (GES) is an emerging therapy for gastric motility disorders, showing improvement of gastroparesis related symptoms in previous studies. Interstitial cells of Cajal (ICC) and mast cells have been shown to have a relevant role in gastroparesis pathogenesis. However, the exact effects of GES in those cells is relatively unknown. Methods Full thickness biopsies (FTBx) of 20 patients with refractory gastroparesis were obtained at the time of GES placement and repeated when the device was exchanged (mean of 22.5 months between biopsies). A patient-reported outcomes survey was obtained during each office visit during this period. All biopsies were stained with cluster of differentiation 117 (CD117), S100, and mast cell tryptase antibodies and were analyzed. Results Half of the patients had a significant increase of ICC during the repeated biopsy compared with baseline (p=0.01) and the other half had significant decrease in ICC levels (p=0.006) but there was no noticeable difference in mast cells counts at baseline between groups. Mast cells analysis was performed in two different groups depending on ICC change from the baseline biopsy (CD117 increase vs CD117 decrease). There was only a significant increase of mast cells count within the CD117 worsened ICC group (p=0.007). Conclusion No significant increase in the number of mast cells count seen in patients who received a GES may indicate an improvement in overall inflammation in patients with refractory gastroparesis after GES placement.
ABSTRACT
An elderly man presented with chronic sleep problems that had recently worsened. He had evidence of disseminated vascular disease with residual left-sided weakness following a stroke. The examination was otherwise unremarkable, but his metabolic profile revealed electrolyte and vitamin deficiencies and an elevated parathyroid hormone level. Electrolytes and vitamins are critical for maintaining physiological balance. Facilitating sleep is especially important in older people for gait stability and sustaining emotional and physical health. Addressing these issues in this patient resulted in improvement, just as it should for other patients.
ABSTRACT
We present the case of a 57-year-old man with known cutaneous manifestations of malignant atrophic papulosis, also known as Köhlmeier-Degos disease, who developed an almost-fatal small bowel perforation following a parathyroidectomy. He required two surgical interventions during his initial hospitalization and was started on eculizumab. Despite these therapies, the patient developed recurrent bowel perforations and ultimately died.
ABSTRACT
Despite the known dangers of cigarette smoking, many smokers do not use effective means for cessation. Smoking-cessation guidelines recommend a variety of psychological and medicinal options that include nicotine-replacement products, pharmaceuticals, and electronic cigarettes. This article describes these smoking-cessation options and provides guidance for physicians.
Subject(s)
Smoking Cessation/methods , Comorbidity , Humans , Mental Disorders/complications , Tobacco Smoking/prevention & controlABSTRACT
A common inhabitant of skin, the Kocuria kristinae of the Micrococcaceae family, has gained attention in recent years because it can induce pathology in humans. Reported is a Kocuria kristinae-caused abdominal abscess in a patient treated for rheumatoid arthritis with adalimumab. The tumor necrosis factor (TNF) inhibitor drugs are known to cause various bacterial, viral, and fungal infections. This is the first known case where an opportunistic infection with Kocuria has presented with an abdominal abscess in an immunocompromised individual who is on long term TNF inhibitors.
Subject(s)
Abdominal Abscess/microbiology , Adalimumab/adverse effects , Arthritis, Rheumatoid/drug therapy , Gram-Positive Bacterial Infections/microbiology , Immunocompromised Host , Abdominal Abscess/etiology , Adalimumab/therapeutic use , Female , Gram-Positive Bacterial Infections/etiology , Humans , Micrococcaceae , Middle Aged , Tumor Necrosis Factor-alpha/antagonists & inhibitorsSubject(s)
Bites and Stings/virology , Infectious Disease Transmission, Vertical , Pregnancy Complications, Infectious/virology , Sexually Transmitted Diseases, Viral/transmission , Zika Virus Infection/transmission , Aedes , Animals , Breast Feeding/adverse effects , Female , Haplorhini/virology , Humans , Male , Mosquito Vectors/virology , Pregnancy , Sexually Transmitted Diseases, Viral/virologyABSTRACT
Control measures include using insect repellents, aerial spraying of insecticides, eliminating mosquito breeding sites, covering water tanks, and using mosquito nets or door and window screens. Infection during pregnancy is the greatest concern because of congenital anomalies (including microcephaly) that negatively affect brain development.
