Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors - A systematic review.

INTRODUCTION: Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors. METHODS: Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis. EXPERT OPINION: A salivary biomarker panel including Interleukin (IL) 1ß, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker's role in disease initiation.

The potential complications of open carpal tunnel release surgery to the ulnar neurovascular bundle and its branches: A cadaveric study.

This study investigated the ulnar artery and the ulnar nerve and its branches in the palm to assess how frequently they may be at risk of damage during open carpal tunnel release surgery. Twenty-one formalin-embalmed cadaveric hands were dissected, and the proximity of the ulnar neurovascular bundle to two different lines of incision, the 3rd and 4th interdigital web space axis and the ring finger axis, was assessed and compared. It was found that an incision in the latter (ring finger) axis put the ulnar artery at risk in 12 of 21 specimens, whereas an incision in the former axis (3rd/4th interdigital web space) put the ulnar artery at risk in only two specimens. In 15 hands at least one structure (the ulnar artery or a branch of the ulnar nerve) was at risk in the ring finger axis compared to only seven hands in the axis of the 3rd/4th interdigital web space. We conclude that the ulnar artery and branches of the ulnar nerve are at increased risk of damage with an incision in the axis of the ring finger. The importance of using a blunt dissection technique under direct vision during surgery to identify and preserve these structures and median nerve branches is emphasized.

The maxillary arch and its relationship to cephalometric landmarks of selected malay ethnic group.

The objectives of this study were to estimate the maxillary arch measurements, to assess the validity of Pont's & Korkhaus' Indices; to determine the relationship between maxillary arch form with head form; and to estimate the cephalic index (CI) of the study population. A cross-sectional study was conducted on 85 mature Malay students, 28 male students (32.98%), 57 females (67.02%) attending Teachers' Training College. Their mean age was 23.9 yr, and Cephalic Index (CI) 86.4 (95% Confidence Interval 85.5-87.3). Arch and head dimensions were significantly larger in males than in females. CI was not significantly different between males and females. Means of anterior arch width (AAW), posterior-arch-width (PAW) and arch-length (Lu) were 35.57mm, 47.3mm and 18.01mm respectively. They were significantly different from their corresponding Indices. Correlation Coefficient between bizygomatic width and anterior-arch-width was 0.18 and was not significant in both sexes of the present population.