Three-coordinate copper(II)-phenolate complexes.

The reactions of LCuCl (L = 2,4-bis((2,6-diisopropylphenyl)imido)pentane (L(iPr)), 2,4-bis((2,6-diisopropylphenyl)imido)-3-chloropentane (L(CliPr))) with the phenolates TlOAr (Ar = C(6)H(3)Me(2), C(6)H(4)OMe, C(6)H(4)tBu) and NaOC(6)H(3)(tBu)(2) were explored. Novel three-coordinate Cu(II)-phenolates, LCuOAr, were isolated from the reactions with the thallium phenolates and were characterized by X-ray crystallography and spectroscopy (UV-vis, EPR). The complexes feature short Cu-O(phenolate) distances (average Cu-O = 1.81 A) and, with one exception, irregular N-Cu-O(phenolate) angles that differ within each compound (15 degrees < Delta < 28 degrees, where Delta = angleN(1)-Cu-O - angleN(2)-Cu-O). The exception is L(iPr)Cu(OC(6)H(4)tBu), for which X-ray structures at -100 and 25 degrees C differed due to an unusual reversible phase change with nonmerohedral twinning (2:1 ratio) in the low-temperature form. The high-temperature form has local C(2)(v) symmetry (Delta = 0 degrees ), and upon cooling below the phase transition temperature (-8 +/- 5 degrees C) lateral movement of the phenolate ligand (Delta = 17.6 degrees ) and rotation of the phenolate plane by 10.7 degrees occurs. Resonance Raman spectroscopic data acquired for L(iPr)Cu(OC(6)H(4)tBu) corroborated assignment of phenolate --> Cu(II) LMCT character in the UV-vis spectra. Cyclic voltammetry experiments (THF, 0.5 M NBu(4)PF(6)) revealed negative E(1/2) values for the Cu(II)/Cu(I) couples relative to NHE, consistent with enhanced stabilization of the Cu(II) state by both the strongly electron donating beta-diketiminate ligand and the phenolates. Although thermally stable, the Cu(II)-phenolates are unusually reactive with dioxygen, albeit to give product(s) that have yet to be identified. In the reaction of L(iPr)CuCl with NaOC(6)H(3)(tBu)(2) no Cu(II)-phenolate was observed. Instead, a Cu(I) complex was generated quantitatively by trapping with added isocyanide, [L(iPr)CuNC(C(6)H(3)Me(2))], along with 3,3',5,5'-tetra-tert-butyl-4,4'-dibenzoquinone and 2,6-di-tert-butylphenol in 27 +/- 3% and 46 +/- 6% yields, respectively, corresponding to the overall reaction 4L(iPr)Cu(II)Cl + 4NaOAr --> 4L(iPr)Cu(I) + 4NaCl + dibenzoquinone + 2(phenol).

[Effect of Corynebacterium parvum preparation on selected immunologic indicators and clinical results in patients with chronic post-traumatic osteomyelitis]. / Wplyw preparatu Corynebacterium parvum na wybrane wskazniki immunologiczne i wyniki kliniczne u chorych na przewlekle pourazowe zapalenie kosci.

Nineteen patients with chronic post-traumatic staphylococcal osteitis++ of a mean 5-years-clinical course were given intramuscularly 3.5 mg of Coparvax for two weeks. An increase of IgG concentration in the serum, starting from the 8th week of observation, and a marked increase of the ability of absorbtion and destruction of staphylococci by the neutrophils of the peripheral blood have been found. It has been accompanied by subsidence of clinical symptoms of ostitis in 13 patients and a marked decrease of intensity of the inflammatory process in 4 other patients. No effect has been found in two patients.

[Plasma and erythrocyte lipids in amyotrophic lateral sclerosis]. / Lipidy osocza i krwinek czerwonych w stwardnieniu bocznym zanikowym.

The authors studied the changes of lipids of the plasma and erythrocytes in 10 cases of amyotrophic lateral sclerosis and in 20 controls matched for age. In the plasma of patients with ALS increased levels were found of free cholesterol and triglycerides, with a decrease of lysophosphatidylcholine. The values of lipid fractions in erythrocyte membranes were not significantly different between these groups, with exception of increased level of total phospholipids (including phosphatidylethanolamine) and cholesterol.

[Lung injuries caused by explosion in rabbits. 3. The behavior of the lung after injury]. / Untersuchungen über Lungentraumen bei Kaninchen durch Luftstosswellen. Teil 3: Das Verhalten der Lungenaktivität nach der Verletzung.

The behaviour of the pulmonary activity was investigated in 30 rabbits after a blast. The estimation was carried out by the results of volumetric, gasometric, and radio-isotopic researches. The results show a considerable disturbance of the pulmonary activity which leads to respiratory insufficiency in rabbits after a blast of medium strength. The restriction type was dominant in the disturbance of the ventilation. An impairment of the gas diffusion is the consequence and leads to hypoxia and to a compensated respiratory acidosis.

[Changes in lipid composition of blood serum and erythrocytes in patients with transient focal cerebral ischemia]. / Zmiany skladu lipidowego surowicy krwi i krwinek czerwonych u chorych z przemijajacym niedokrwieniem ogniskowym mózgu.

Determinations of the lipid pattern of the serum and erythrocytes were carried out in 27 patients with transient focal cerebral ischaemia and in 20 healthy subjects. In the group of patients with transient focal cerebral ischaemia the levels of total lipids, phospholipids and cholesterol were higher in the serum and erythrocytes than in healthy controls.

[Incidence of urinary tract diseases among workers in the Masovian Refining and Petrochemical Plants in Plock 1978-1981]. / Czestosc wystepowania chorób narzadów ukladu moczowego u pracowników Mazowieckich Zakladów Rafineryjnych i Petrochemicznych w Plocku w latach 1978-1981.

The studies were aimed at estimation of the incidence rate of genito-urinary tract diseases among employees of the Mazovian Refining and Petrochemical Plants in Plock. In 1978-1981, 873 employees were examined, including 244 females and 629 males. Most of them, namely 572 (65%), were employed in those plants for more than 5 years. In 190 persons (21.8%) either history of urologic diseases (41 persons) or current diseases (149 persons) were found. The incidence rate of genito-urinary tract diseases was similar to that observed in general population. The studies are continued.

[Comparative studies on the lipid content of the cerebrospinal fluid and serum lipoprotein fractions in patients with discopathic changes]. / Badania porównawcze skladu lipidowego plynu mózgowo-rdzeniowego oraz frakcji lipoproteidowych surowicy krwi u osób ze zmianami dyskopatycznymi.

The reported investigations were carried out in 12 subjects with low back pains caused by lumbar discopathy. The studied material were cerebrospinal fluid samples obtained during lumbar tap and blood obtained from the antecubital vein. In the fluid, serum and lipoprotein fractions the concentrations of cholesterol, triglycerides and phospholipids were determined. It was found that the concentration of the lipids determined in the cerebrospinal fluid in patients with discopathy was not different from that demonstrated in healthy subjects. The lipid content of the fluid differed significantly from that of the serum but was very similar to the composition of lipids in the high density lipoprotein fraction (HDL). The summed up concentration of cholesterol, triglycerides and phospholipids was about 170 times lower than that in the HDL fraction.

Furosemide effect on gastric basal secretion during exercise and postexercise restitution in healthy subjects.

The purpose of this work was determination of furosemide effect on basal gastric secretion during exercise and postexercise restitution in 8 healthy men aged 22-25 years. The investigations were performed three times determining each time the basal acid output during three successive hours. In the first test the determinations were done during one hour rest, then after intravenous furosemide administration 2 mg/kg, and again between 60 and 120 minutes after the injection. In the second test BAO was determined at rest, during one-hour exercise, and during restitution. In the third test the determinations were done at rest, during exercise preceded by furosemide injection as in the first test, and during one hour of post-exercise restitution. The exercise on a Monark cycle ergometer was, on the average, 275 210 +/- 12 500 J in the second test and 284 870 +/- 14 480 J in the third test. Furosemide caused a statistically significant decrease of BAO at rest (p less than 0.02) and during exercise (p less than 0.01), this was due to a significant reduction in gastric juice volume (p less than 0.001) and in the second hour of furosemide action also to a decrease of HCI concentration (p less than 0.05). Decreased excretion of electrolytes by the gastric mucosa was proportional to changes in gastric juice volume. The 24-hour urinary excretion of sodium, potassium and chlorides increased after furosemide in the first test (p less than 0.001), and in the third test (p less than 0.02).

Changes in the concentrations of certain biochemical parameters in the peripheral blood during exercise and restitution after bloodletting.

The reported investigations were carried out in 18 men aged 19 to 23 years in whom 400 ml of whole blood was removed. On the day before bloodletting, one hour and 24 hours after it the studied men carried out a 10 minute exercise on a Monark cycle ergometer at a workload raising the heart rate to 170/min. Before the exercise, immediately after it and in the 30th minute of restitution venous blood samples were taken for determinations of the concentrations of total protein, albumins, free fatty acids, glucose, lactate and pyruvate, and the activity of lactic dehydrogenase, alanine aminotransferase and aspartate aminotransferase. During that time the acid-base equilibrium was determined in capillary blood. After bloodletting the concentrations of albumins, total protein and free fatty acids were decreased parallelly to haematocrit value decrease (p less than 0.05) and glucose concentration increased slightly (p less than 0.05). Enzyme activity was decreased slightly (p greater than 0.05). The partial oxygen pressure decreased, that of carbon dioxide increased, and hydrogen ion concentration rose. These changes were more pronounced after 24 hours than 1 hour after bloodletting. After submaximal exercise and in the 30th minute of restitution as well as 1 and 24 hours after bloodletting the changes in the concentrations of the biochemical parameters, enzyme activity and acid-base equilibrium were similar as after bloodletting.