Comparison of the Effect of the Jaw Thrust Maneuver, Chin Lift, Head Rotation, and Tongue Protrusion on the Obstruction of Different Levels of the Upper Airway During the Drug-Induced Sleep Endoscopy: A Cross-Sectional Study.

To determine the impact of four maneuvers (Jaw Thrust, Chin Lift, Head Rotation, and Tongue Protrusion) on the degree of airway collapse at different airway levels during drug-induced sleep endoscopy (DISE) compared with natural supine position (regular) DISE and evaluate the association of each maneuver with polysomnographic findings compared with regular DISE without any maneuver. One hundred and nine OSA patients aged 20 to 55 who were candidates for sleep surgery were included. The association of the Apnea Hypopnea Index (AHI) with the degree of obstruction during four maneuvers of DISE and regular DISE was evaluated. AHI is significantly predicted by degree of obstruction at the velum (regular DISE) (ß = 10.213), oropharynx (regular DISE) (ß = 7.979), velum (jaw thrust DISE) (ß = 12.286), oropharynx (jaw thrust DISE) (ß = 8.430), velum (head rotation DISE) (ß = 10.357), and velum (chin lift DISE) (ß = 10.781). In the multivariate model, AHI was predicted by the velum during the jaw thrust maneuver (ß = 7.985). Velum obstruction during DISE with jaw thrust, closing, and rotation maneuvers can significantly predict AHI. The degree of velum collapse during the jaw thrust maneuver is the most reliable and independent finding that correlates with the severity of obstructive sleep apnea. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-023-04470-1.

Olfactory Dysfunction is Associated with More Severe Clinical Course in COVID-19.

To perform a quantitative olfactory test in positive COVID19 RT-PCR admitted patients and asymptomatic ones, to evaluate the association between hyposmia and disease severity. This is a Cross sectional study. Ninety-one patients including 68 inpatients and 23 asymptomatic healthcare workers with positive COVID-19 RT-PCRs. Methods: Demographics and clinical characteristics were collected. Iran Smell Identification Test (IR-SIT), a highly accurate 6-odorant test was used to evaluate the reliability of self-reported hyposmia and determine the correlation of the measured olfactory dysfunction with disease severity. Twenty-two of 91 patients (24%) reported hyposmia, while 41/91 (45%) patients had measurable olfactory dysfunction (IR-SIT score 1-4, p < 0.05). Mean age of the 68 inpatients and 23 asymptomatic patients were 43.97 ± 16.13 years; M:F 43:25, and 43.87 ± 12.76 years; M:F 8:15 respectively. Of 68 patients, 20 were graded as severe, and 48/68 had mild course of disease. IR-SIT detected hyposmia in 80% of patients with severe disease, and 50% with mild disease, respectively. The risk of disease severity was significantly increased for patients with olfactory dysfunction and was detected 4 times higher when compared to patients with mild disease (OR 4, 95% CI: 1.166-13.728, p = 0.028). Olfactory Dysfunction was present in 80% of patients with severe course. The risk of disease severity is significantly increased with olfactory dysfunction in admitted patients.