Thromboembolic events in inflammatory bowel disease.

GOAL OF THE STUDY: Inflammatory bowel disease (IBD) is associated with an increased risk of thromboembolic events (TEE) during outbreaks, increasing morbidity and mortality. The aim of our study was to specify the prevalence of TEE in IBD patients and to determine their epidemiological, clinical and evolutionary characteristics. MATERIEL AND METHODS: This is a retrospective study collecting all patients with IBD, who had a thromboembolic complication confirmed by imagery, between January 2012 and December 2018. RESULTS: One hundred patients with IBD were diagnosed during the study period. A TEE occurred in 6 patients (5.9%). These patients had an average age of 41 years, divided into 4 women and 2 men. Five patients had Crohn's disease and one patient had ulcerative colitis. The IBD was active in all patients. Five patients were already hospitalized and under preventive heparin therapy. Patients had deep venous thrombosis of the lower limbs in 3 cases, associated with pulmonary embolism in 1 case, cerebral venous thrombosis in 2 cases and pulmonary embolism isolated in 1 case. Thrombophilia investigations were negative in all patients. Evolution under medical treatment was favorable in 4 patients and fatal in 2 patients. CONCLUSION: In our study, the prevalence of TEE in patients with IBD was 5.9%. Thrombosis occurred during the active phase of IBD in all cases.

Magnetic and structural properties of single-phase Gd3+-substituted Co-Mg ferrite nanoparticles.

Nanocrystalline Gd3+-doped Co-Mg ferrite nanoparticles with the chemical formula Co0.7Mg0.3Fe(2-x)Gd x O4 (x = 0.02) were prepared by coprecipitation for the first time. The properties of the nanoparticles were investigated by X-ray diffraction, confirming a single-phase, highly crystalline cubic spinel structure in the space group Fd3̄m and an average crystallite size of 54 nm. The Fourier-transform infrared spectrum showed two fundamental absorption bands in the wavenumber range of 437-748 cm-1 attributed to the stretching vibration of tetrahedral and octahedral sites in the spinel structure. Scanning electron microscopy analysis showed that the nanoparticles are different in shape and slightly agglomerated. Energy-dispersive X-ray spectroscopy demonstrated the purity of the nano-ferrite powder. Magnetic measurements revealed ferrimagnetic behavior at room and low temperatures with high coercivity and a high saturation magnetization of 95.68 emu g-1, larger than that of pure bulk cobalt ferrite (80.8 emu g-1). Only ferrite cobalt synthesized sonochemically has been reported to have a higher saturation magnetization (92.5 emu g-1).

[Bowel-associated dermatosis-arthritis syndrome during ulcerative colitis: A rare extra-intestinal sign of inflammatory bowel disease]. / Syndrome arthro-cutané lors d'une rectocolite ulcéro-hémorragique : une manifestation extra-intestinale rare des maladies inflammatoires de l'intestin.

INTRODUCTION: Bowel-associated dermatosis-arthritis syndrome (BADAS) is characterized by combined pustular skin eruption and arthralgia. It may be associated with inflammatory bowel disease or bowel bypass surgery. We report a case of BADAS in a patient with ulcerative colitis. CASE REPORT: A 39-year-old woman was being treated for a severe flare-up of ulcerative colitis present over the preceding 2 months and treated with prednisone, azathioprine and cyclosporine. She was also presenting a cutaneous eruption and arthralgia that had begun three days earlier. Dermatological examination revealed profuse vesicular and pustular lesions. Biopsy specimens showed mature neutrophilic infiltrate within the dermis. A diagnosis of BADAS was made and the same treatment was maintained. Systemic symptoms were resolved but the vesicular lesions were superseded by hypertrophic scars. DISCUSSION: Bowel-associated dermatosis-arthritis syndrome consists of a vesiculopustular eruption associated with arthralgia and/or arthritis and fever, as was the case in our patient. The histological picture is characterized by abundant neutrophilic infiltrate in the superficial dermis. The clinical and histological features and the course of BADAS allow this entity to be classified within the spectrum of neutrophilic dermatoses. Treatment chiefly involves systemic corticosteroids.