Local and global processing in blind and sighted children in a naming and drawing task.

This study investigated the spatial analysis of tactile hierarchical patterns in 110 early-blind children aged 6-8 to 16-18 years, as compared to 90 blindfolded sighted children, in a naming and haptic drawing task. The results revealed that regardless of visual status, young children predominantly produced local responses in both tasks, whereas the production of integrated responses emerged later. Development of local and global processing seems to proceed similarly in the two populations, but local processing continued to occur at high levels over a larger age range in the blind. The possibility of visual mediation is pointed out, as totally blind children tended to process information locally more often than blind children with minimal light perception.

The causal representation of outpatients with Crohn's disease: is there a link between psychological distress and clinical disease activity?

OBJECTIVES: Because of the fluctuating and occasional character of Crohn's disease (CD), patients have to cope with a changeable condition of health. Personal perceived control is known to be an important element of adaptation to their medical condition. The objectives of this work are to determine if perceived personal control is predictive of the clinical activity of the disease and of psychological distress (depression, anxiety). METHODS: The Hospital Anxiety Depression Scale (HADS), the causal dimension scale and the Clinical Global Impression (CGI; assessing perceived severity) were administered to 160 patients affected by Crohn's disease. Indicators of inflammation (CRP), disease duration and clinical activity of the disease were also asessed. RESULTS: Globally, CD patients perceive their disease as being personally neither controllable nor uncontrollable. Whereas psychological distress is significantly higher when the disease is active, the relationship between the variables appears complex. The feeling of personal control is explained by the clinical activity of the disease (p=.0001) and by the perception that CD is unstable (p<.00001) and globally impacts the life of patients (p=.001). Nevertheless perception of personal control does not explain the clinical activity of the disease. Finally, psychological distress is explained by the perception that the medical team is unable to control the disease (p=.00001) and by the global consequences of the disease on life (p<.005). CONCLUSIONS: Psychological treatments should take these dimensions into account so as to improve the well-being and medical conditions of patients.

Using a Multi-Locus Microsatellite Typing method improved phylogenetic distribution of Candida albicans isolates but failed to demonstrate association of some genotype with the commensal or clinical origin of the isolates.

The dimorphic yeast Candida albicans is a component of the normal microflora at the mucosal surfaces of healthy individuals. It possesses an array of phenotypic properties considered as virulence traits that contribute to pathogenicity of the yeast in immuno-compromised patients. We addressed the question of the pathogenicity of lineages of C. albicans with regard to their genotype in three series of C. albicans isolates (a series of commensal isolates collected in healthy individuals, a group of bloodstream isolates and a group of non-bloodstream clinical isolates) using a Multi-Locus Microsatellite Typing (MLMT) approach based on the analysis of the polymorphism of 11 microsatellite loci. The MLMT analysis of the three series, corresponding to 174 C. albicans isolates, gave a 100% typability to the method, with a DP index of 0.999. The UPGMA analysis showed that the isolates segregated in eight phylogenetic groups. Interestingly, the clustering was comparable when using NJ and MS-tree algorithms and a good concordance index of the clustering was observed with MLST. All in all our data strongly indicated MLMT as a reliable tool for DNA-typing studies in C. albicans. Isolates from healthy and non-healthy individuals segregated at the same proportions into the eight phylogenetic groups, suggesting that isolates of different origin share the same overall pathogenicity. Surprisingly allelic frequencies at the HIS3 microsatellite differed significantly in commensal isolates (group A) from pooled groups B and C (clinical isolates), raising the possibility that some individual alleles at the HIS3 microsatellite may be associated with distinct pathogenic profiles in C. albicans.

Personality and fatigue perception in a sample of IBD outpatients in remission: a preliminary study.

BACKGROUND AND AIMS: Fatigue is considered as a feature of IBD. Nevertheless, medical variables would partly explain this complex phenomenon. Psychological variables would be especially connected to fatigue for patients in remission. Moreover, personality is known to be linked to the fatigue of patients with CFS. This preliminary study aimed to determine if personality dimensions are linked to the perception of fatigue in IBD. METHODS: 81 IBD outpatients in remission completed the MFI (fatigue); ISI, EES (sleep disturbances); TCI-R (personality); HADS (depression and anxiety). Medical data were collected (ferritin, C-reactive protein, number of flare-ups, number of hospitalizations, duration of the disease and surgical sequelae). RESULTS: With the exception of surgical sequelae, none of the medical variables was linked to fatigue perception. Anxiety and sleep disturbances were the most continuously connected to fatigue perception. Significant relationships were observed between personality categorization on Persistence, Self-Directness and the level of fatigue. CONCLUSION: In order to improve vitality in IBD patients in remission, identification and treatment of psychological aspects should become a dimension of disease management. Fatigue should not be considered only as a direct feature of IBD.

Diagnostic profiles determined by the C.A.R.T procedure: IBD patients and fatigue.

Fatigue is common in IBD. It remains a complex phenomenon with primary factors related to the disease and secondary factors (depression, anxiety, sleep disturbances, pain) whose respective importance and organization are difficult to determine. By using the C.A.R.T. procedure, the diagnostic variables of 108 IBD-related fatigue patients were determined globally, according to their sex and the clinical activity of their disease. Results underline the diversity of diagnostic profiles in which psychological variables have significant influence. It is important to consider fatigue according to profiles that best illustrate its complexity and allow for identifying better potentially remediable factors.

A prospective analysis of the genotypic diversity and dynamics of the Candida albicans colonizing flora in neutropenic patients with de novo acute leukemia.

BACKGROUND: Genotyping studies have shown heterogeneity of Candida albicans flora in patients with human immunodeficiency virus infection, with possible co-existence of multiple clones with distinct resistance patterns. We report the result of a prospective study aimed at investigating the dynamics and heterogeneity of C. albicans flora in patients with de novo acute leukemia. DESIGN AND METHODS: Between 2001 and 2003, 66 consecutive adults with newly diagnosed acute leukemia were monitored for Candida colonization. From 19 patients with repeated multi-site C. albicans colonization, eight were randomly selected and multiple isolates from each individual mucosal site were genotyped sequentially over time using microsatellite markers. RESULTS: Despite topical use of polyenes, 60.6% of the patients were colonized repeatedly and at multiple sites. Altogether, 2,730 peripheral samples were cultured, 379 (13.9%) of which yielded yeasts. C. albicans was the most common species recovered (68%). From eight randomly selected patients colonized with C. albicans, 429 isolates were genotyped. Seven patients carried a unique genotype which was identical in all body niches and over the period of study. In one case, minor genotypic differences were observed. None of the patients shared C. albicans clones with identical genotypic profiles. Candidemia occurred in one of eight patients and the blood strain genotype did not differ from those of colonizing isolates. The genotypic profile was not altered by topical and/or systemic use of antifungal agents in any of the patients. CONCLUSIONS: In patients with de novo acute leukemia, genetic evolution of the colonizing C. albicans flora and selection of variants or replacement of the original strain upon antifungal drug pressure or nosocomial transmission are rare events.

Relationships between coping strategies and defense mechanisms in sport performance.

In an exploratory study, the relationships between two major concepts in psychological adjustment, coping strategies, and defense mechanisms were investigated. Sport competition is an example of a real-world context in which people's responses to stressful situations can be investigated. The extent to which participants reported different uses of coping strategies and defense mechanisms was assessed in terms of performance. 26 elite kayakers were classified into one of two groups, depending on the discrepancy between their standard performance and their performance in competition. Correlations were found among the coping strategies of seeking social support, positive reappraisal/planful problem solving, and mature defenses and between the coping strategy of distancing/avoidance and immature defenses. The results of multivariate and univariate analyses confirmed a significantly different use of coping strategies and defense mechanisms between the two performance groups. In light of these findings, certain recommendations in terms of methodology and application are warranted. Coping strategies and defense mechanisms should be studied to improve adjustment to sport performance.

Effects of an informational CD-ROM on anxiety and knowledge before aesthetic surgery: a randomised trial.

This trial aimed to assess the value of visual information by CD ROM before aesthetic breast reduction or abdominoplasty. All included patients were given an information leaflet about the procedure and completed a Spielberger state-trait anxiety inventory (STAI form Y-1) questionnaire to assess situational anxiety. The patient was then randomly assigned to watch or not to watch an informational CD ROM. The day before surgery the patient completed a second anxiety questionnaire and a knowledge questionnaire. Eighty patients were included, 40 were assigned the CD ROM and 40 no CD ROM. Patients who watched the CD ROM were significantly less anxious than those who did not (Mean STAI 45 [38.2-46.3] vs 55 [49.9-63.8]). Furthermore they also scored higher in the knowledge questionnaire as far as the purpose and the procedural details of the surgery were concerned. However, no statistical difference of knowledge regarding the potential complications of the procedure was found.

Rorschach variables related to blood glucose control in insulin-dependent diabetes patients.

In this article, we explored relations between selected Rorschach variables and blood glucose control in Insulin-Dependent Diabetes Mellitus (IDDM) patients. Three domains of psychological functioning are taken into consideration: emotional distress, coping and problem solving, and cognitive efficiency. Seventy-one IDDM patients (38 men, 33 women; mean age 42.2 +/- 14.9 years) from an outpatient unit took the Rorschach Comprehensive System (Exner, 1986). Nine variables were selected as independent variables. Blood glucose, a dependent variable, was measured by the proportion of glycated hemoglobin. Results of 2 regression analyses show that Y and C' correlate to higher blood glucose. WSum C and the absence of texture related to lower levels of blood glucose. A confounding effect of complications was observed. The findings suggest that emotional factors should be accorded greater attention in behavioral self-regulations in diabetes.