1.
Brain Res
; 673(1): 157-60, 1995 Feb 27.
Article
in English
| MEDLINE
| ID: mdl-7757470
ABSTRACT
Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.
Subject(s)
Anticonvulsants/pharmacology , Benzocycloheptenes/pharmacology , Neural Conduction/drug effects , Prefrontal Cortex/drug effects , Sodium Oxybate/pharmacology , Animals , Dose-Response Relationship, Drug , Electrophysiology , Male , Prefrontal Cortex/physiology , Rats , Rats, Sprague-Dawley , Time Factors
2.
Vet Med Small Anim Clin
; 73(1): 41-4, 1978 Jan.
Article
in English
| MEDLINE
| ID: mdl-245880