ABSTRACT
BACKGROUND: Basal cell carcinoma (BCC) occurs frequently in young patients with xeroderma pigmentosum (XP). Because tumours are multiple and usually found on the face, alternatives to surgery are proposed. The purpose of this study was to evaluate the efficacy of cryosurgery for BCC in XP patients. PATIENTS AND METHODS: This was a retrospective study that included all instances of BCC occurring in XP patients treated by cryosurgery between January 2002 and October 2008. RESULTS: Forty-five cases of primary facial BCC and one case of relapsing BCC (16 on the cheeks, 11 on the nose, six on the face and five on the inner edge of the eye area) were treated by cryosurgery in 18 XP patients (average age: 18.7 years; sex ratio: 0.5). Mean carcinoma size was 10mm. Thirty-six tumours were nodular and 10 were nodular and ulcerated. Follow-up ranged from 16 to 60 months (mean: 30 months). Complications were rare. Cosmetic results were satisfactory. We noted 10 cases of hypopigmentation (21.7%) and one notch on the nose following treatment for recurrent BCC on a radiotherapy scar. Relapse occurred in one case (2.17%). CONCLUSION: Because of its simplicity, its good safety, its sparing of skin and its reliability of oncological outcome, cryosurgery is the treatment of choice for CBC in XP patients.
Subject(s)
Carcinoma, Basal Cell/surgery , Cryosurgery/methods , Facial Neoplasms/surgery , Head and Neck Neoplasms/surgery , Skin Neoplasms/surgery , Xeroderma Pigmentosum/surgery , Adolescent , Adult , Carcinoma, Basal Cell/diagnosis , Child , Facial Neoplasms/diagnosis , Female , Head and Neck Neoplasms/diagnosis , Humans , Male , Neoplasm Recurrence, Local/diagnosis , Neoplasm Recurrence, Local/surgery , Reoperation , Retrospective Studies , Skin Neoplasms/diagnosis , Xeroderma Pigmentosum/diagnosis , Young AdultABSTRACT
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Subject(s)
Humans , Female , Adult , Neoplasms, Basal Cell/diagnosis , Eyelid Neoplasms/diagnosisSubject(s)
Carcinoma, Squamous Cell/diagnosis , Submandibular Gland Neoplasms/diagnosis , Aged , Humans , MaleSubject(s)
Acrospiroma/pathology , Skin Neoplasms/pathology , Adult , Female , Humans , Skin PigmentationABSTRACT
Trigeminal trophic syndrome, a rare cause of facial ulceration, is the consequence of damage to the trigeminal nerve or its central sensory connections. We report two cases of trigeminal trophic syndrome, complications of cerebral vascular accidents. A 65-year-old woman complained of numerous and progressive ulcers of the right side of her face of 2 month's duration. A 67-year-old woman presented with an ulcer of the ala nasi of 10 week's duration. This syndrome most commonly occurs in women with an average age of 57 years. About 100 cases are reported in the literature. The diagnosis is made on clinical grounds, and is suggested when loss of sensation occurs in association with unilateral facial ulceration, especially involving the ala nasi. Once the ulcers appear, they are extremely persistent.
