Subject(s)
Insecticides/therapeutic use , Lice Infestations/drug therapy , Pediculus , Physician Assistants , Animals , Child , HumansSubject(s)
Influenza in Birds/prevention & control , Influenza, Human/prevention & control , Physician Assistants , Animals , Birds , Disease Outbreaks/prevention & control , Education, Continuing , Humans , Influenza A Virus, H5N1 Subtype/pathogenicity , Influenza in Birds/epidemiology , Influenza in Birds/transmission , Influenza in Birds/virology , Influenza, Human/epidemiology , Influenza, Human/transmission , Influenza, Human/virology , Physician Assistants/educationABSTRACT
A 15-year-old Caucasian boy experienced severe fever, fatigue, and a 40-lb weight loss after 2 years of minocycline therapy. A workup for infectious causes was negative. One week after minocycline discontinuation, the patient reported that his fever had resolved. Two months later, he reported full resolution of symptoms, weight gain, and a return to normal activity. An objective causality assessment indicated that his illness probably was caused by minocycline, which is considered a safe drug; however, it has been associated with rare serious adverse effects. This patient's presentation of fever was noteworthy not only because minocycline is a rare cause of drug fever, but also because of the delayed onset. Clinicians should be aware that minocycline may cause severe fever and illness even after an extended period of drug exposure.