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Sci Rep ; 12(1): 3863, 2022 03 09.
Article in English | MEDLINE | ID: mdl-35264588

ABSTRACT

The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.


Subject(s)
Antibodies, Monoclonal , Neoplasms , Animals , Humans , Mice , Positron-Emission Tomography/methods , Radioisotopes , Radiopharmaceuticals , Receptors, Urokinase Plasminogen Activator , Urokinase-Type Plasminogen Activator
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