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1.
Clin Orthop Surg ; 14(3): 352-360, 2022 Sep.
Article in English | MEDLINE | ID: mdl-36061840

ABSTRACT

Background: The purpose of this study was to analyze the epidemiology of T-score discordance between the spine and femur in the South Korean population and compare the prevalence of T-score discordance between the Korean osteoporosis population and atypical femoral fracture (AFF) patients. Methods: A total of 12,422 subjects from the Korea National Health and Nutrition Examination Survey were reviewed retrospectively. T-score discordance was defined as a difference of ≥ 1 standard deviation between the lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD). The prevalence of T-score discordance (low LS [LS BMD < FN BMD], low FN [LS BMD > FN BMD], and total [low LS + low FN]) was investigated in the osteoporosis and non-osteoporosis groups and stratified by sex and age. T-score discordance of 63 patients with AFFs diagnosed at a single institution was compared with that of the Korean osteoporosis population using propensity score matching. Results: T-score discordance was prevalent in the Korean osteoporosis population (44.8%), and low LS discordance (37.5%) was more frequently seen than low FN discordance (7.2%) (p < 0.001). The prevalence of total and low LS discordance was significantly higher in AFF patients than in the Korean osteoporosis population (total discordance: 69.8% and 42.5%, respectively; low LS discordance: 63.5% and 31.7%, respectively; p < 0.001). Conclusions: T-score discordance was highly prevalent in the Korean osteoporosis population, and low LS discordance was more common than low FN discordance. Nevertheless, the prevalence of low LS discordance was significantly higher in AFF patients than in the Korean osteoporosis population.


Subject(s)
Femoral Fractures , Osteoporosis , Bone Density , Humans , Lumbar Vertebrae , Nutrition Surveys , Osteoporosis/epidemiology , Registries , Republic of Korea/epidemiology , Retrospective Studies
2.
Knee Surg Sports Traumatol Arthrosc ; 30(6): 2113-2122, 2022 Jun.
Article in English | MEDLINE | ID: mdl-34988632

ABSTRACT

PURPOSE: In large-to-massive rotator cuff tears (MRCTs), incorporating the long head of the biceps tendon (LHBT) with arthroscopic partial rotator cuff and margin convergence can improve clinical outcomes and preserve the acromio-humeral interval (AHI) during mid-term follow-up. The purpose of this study was to evaluate mid-term clinical and radiological outcomes of arthroscopic biceps-incorporating rotator cuff repair with partial release of the LHBT and footprint medialization through the Neviaser portal in MRCTs. METHODS: This study enrolled 107 patients (38 males and 69 females, mean age: 64.9 ± 8.6 years) with MRCTs. A novel arthroscopic biceps-incorporating repair was performed by footprint medialization, with a partially released biceps tendon covering central defects. Clinical outcomes such as pain VAS, KSS, ASES, UCLA, SST and CS scores and ROM were evaluated at a mean follow-up time of 35 months (range 12-132 months). Serial radiographs with a mean postoperative MRI follow-up duration of 33 months were used to evaluate AHI, tendon integrity, fatty infiltration (FI) and muscle hypotrophy. RESULTS: Postoperative pain VAS, KSS, ASES, UCLA, SST, and CS scores and ROM (except external rotation) were improved significantly. AHI also improved significantly from 8.6 to 9.3 mm. According to Sugaya's classification, type I, II, III, IV, or V healing status was found in 30 (28.0%), 29 (27.1%), 26 (24.3%), 14 (13.1%), and 8 (7.5%) patients, respectively. The retear rate was 22 (20.6%). CONCLUSIONS: Novel biceps-incorporating cuff repair with footprint medialization yielded satisfactory outcomes in MRCT patients at the 3-year follow-up. A partially released, repaired biceps tendon provided superior stability with preserved AHI similar to that of anterior cable reconstruction. LEVEL OF EVIDENCE: IV.


Subject(s)
Rotator Cuff Injuries , Aged , Arthroscopy , Female , Humans , Male , Middle Aged , Range of Motion, Articular , Rotator Cuff/diagnostic imaging , Rotator Cuff/surgery , Rotator Cuff Injuries/diagnostic imaging , Rotator Cuff Injuries/surgery , Tendons/surgery , Treatment Outcome
3.
J Arthroplasty ; 35(9): 2444-2450, 2020 09.
Article in English | MEDLINE | ID: mdl-32487501

ABSTRACT

BACKGROUND: We determined whether postoperative intravenous (IV) iron supplementation could reduce transfusion rate in patients undergoing staged bilateral total knee arthroplasty (TKA). Furthermore, we examined whether hemoglobin (Hb) levels and iron profile differed between patients with and without postoperative IV iron supplementation. METHODS: This retrospective, comparative cohort study included 126 patients who underwent primary staged bilateral TKA during a single hospitalization. The second TKA was performed at a week's interval. Group iron (n = 65) received IV iron immediately after each surgery, while patients in group no-iron (n = 61) received no iron after surgery. Transfusion rate, change in Hb levels, and iron profile including serum iron, ferritin, total iron binding capacity, and transferrin saturation were evaluated preoperatively; on postoperative days 1, 2, and 4 after the first TKA; and postoperative days 1, 2, 4, and 7, 6 weeks, and 3 months after the second TKA. RESULTS: There were no significant differences in Hb levels and transfusion rate following staged bilateral TKA between patients with and without postoperative IV iron supplementation although serum iron profiles were improved in patients with IV iron supplementation. CONCLUSION: Postoperative IV iron supplementation immediately after acute blood loss caused by TKA was not effective in improving the transfusion rate. Therefore, surgeons should use protocols other than postoperative IV iron supplementation for reducing the transfusion rate in patients undergoing staged bilateral TKA in a single hospitalization. LEVEL OF EVIDENCE: III.


Subject(s)
Antifibrinolytic Agents , Arthroplasty, Replacement, Knee , Tranexamic Acid , Arthroplasty, Replacement, Knee/adverse effects , Blood Loss, Surgical , Cohort Studies , Dietary Supplements , Hemoglobins/analysis , Humans , Iron , Postoperative Hemorrhage , Retrospective Studies
4.
Medicine (Baltimore) ; 98(27): e16253, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31277144

ABSTRACT

RATIONALE: Peroneal nerve injury is one of the major complications that may occur after closing wedge high tibial osteotomy (CWHTO). In contrast, the reduced risk of the peroneal nerve injury has been considered as one of the advantages of opening wedge HTO (OWHTO). PATIENT CONCERNS: A 61-year-old male who underwent OWHTO showed a dropped big toe immediately after surgery. DIAGNOSIS: Injury of deep peroneal nerve was confirmed by electrodiagnostic study. It was probably caused by a posterolaterally protruded screw. INTERVENTIONS: The protruded screw was replaced with a shorter one 3 weeks after OWHTO. OUTCOMES: The motor weakness and sensory reduction were completely recovered at 9 months after surgery. LESSONS: OWHTO has been known to be safe from peroneal nerve injury. However, considering the anatomical course of deep peroneal nerve, great care should be taken to avoid damage to the deep peroneal nerve while drilling holes and inserting distal screws toward the posterolateral aspect of the proximal tibia.


Subject(s)
Osteoarthritis, Knee/surgery , Osteotomy/adverse effects , Peroneal Nerve/injuries , Peroneal Neuropathies/etiology , Postoperative Complications , Tibia/surgery , Electrodiagnosis/methods , Follow-Up Studies , Humans , Male , Middle Aged , Osteotomy/methods , Peroneal Neuropathies/diagnosis
5.
Knee ; 25(6): 1192-1196, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30414792

ABSTRACT

BACKGROUND: This study aimed to determine the prevalence of excessive lateral pressure syndrome (ELPS) in potential candidates for high tibial osteotomy (HTO) using single-photon emission computed tomography-computed tomography (SPECT-CT). We also sought to identify risk factors related to the presence of ELPS. METHODS: This retrospective study included 150 patients (216 knees) who were candidates for HTO from an initial screening of 3579 patients (7158 knees). There were 183 female and 33 male knees with a mean age of 58 years. The presence of ELPS was defined as a grade 3 uptake on the SPECT-CT at the lateral PF joint. To determine the risk factors related to the ELPS, multivariate regression analysis was performed with independent demographic and radiographic variables. RESULTS: Increased uptake on the lateral side of the PF joints was detected in 120 knees (56% of total subjects). Of these, 34 (16%) knees presented with a grade 3 uptake, which indicated the presence of ELPS. No single risk factor had significant associations with the presence of ELPS. CONCLUSIONS: A considerable number of the knees that were candidates for HTO had ELPS. Nonetheless, we did not find any risk factor related to the presence of ELPS. These results suggest that surgeons should be cautious when diagnosing concomitant ELPS despite acceptable radiographic findings from patellofemoral joints when performing HTO.


Subject(s)
Osteoarthritis, Knee/surgery , Osteotomy/methods , Patellofemoral Joint/diagnostic imaging , Aged , Female , Humans , Male , Middle Aged , Prevalence , Retrospective Studies , Risk Factors , Single Photon Emission Computed Tomography Computed Tomography , Tibia/surgery
6.
PLoS One ; 13(10): e0205168, 2018.
Article in English | MEDLINE | ID: mdl-30308050

ABSTRACT

The purpose of this study was to assess the overall clinical results and range of motion (ROM) after total knee arthroplasty (TKA) in patients with preoperative stiffness. We also aimed to determine whether the severity or cause of the stiffness can affect the clinical outcome after surgery. This retrospective study included 122 knees (117 patients) with follow-up of more than 2 years (mean age, 64.3 years). TKA was performed using posterior-stabilized, varus-valgus constrained (VVC), and hinged prostheses. To determine the effect of the severity of stiffness on the clinical outcome, the subjects were divided into two groups: the severe group (preoperative ROM ≤ 50°; 18 knees) and the moderate group (preoperative ROM, 50°-90°; 104 knees). Then, clinical results and ROM were compared according to the severity or cause of preoperative stiffness. After surgery, preoperative ROM (mean, 78°; range, 25°- 90°) was improved (mean, 107°; range, 70°- 130°). The severe group more frequently used the VVC or hinged prostheses (72% vs. 18%). Furthermore, the severe group had worse knee and function scores as well as more complications (33% vs. 13%), even though the severe group had a greater ROM increment (47° vs. 27°) after surgery. Patients with osteoarthritis and rheumatoid arthritis showed better ROM and clinical results compared to patients with infectious or traumatic arthritis. Although TKA in stiff knees can be successful, the results are inferior in knees with severe stiffness and knees with infectious or traumatic arthritis.


Subject(s)
Arthritis/surgery , Arthroplasty, Replacement, Knee , Range of Motion, Articular , Adult , Aged , Aged, 80 and over , Arthritis/etiology , Female , Follow-Up Studies , Humans , Knee Joint , Knee Prosthesis , Male , Middle Aged , Postoperative Complications , Preoperative Period , Retrospective Studies , Severity of Illness Index , Treatment Outcome
7.
Scand J Med Sci Sports ; 28(12): 2604-2610, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30102809

ABSTRACT

BACKGROUND: Some patients with recurrent symptomatic instability after primary anterior cruciate ligament (ACL) reconstruction have an extension deficiency (ED). This study (a) compared preoperative clinical conditions between the ED and non-ED groups undergoing revision ACL reconstruction, (b) documented clinical and arthroscopic findings in ACL-reconstructed patients with reinstability and ED, and (c) determined whether the ED could be resolved and whether the clinical results of revision surgery differed between the ED and non-ED groups. METHODS: This study included 58 patients who underwent revision ACL reconstruction. Patients were divided into the ED and non-ED groups. Preoperatively, the demographics and clinical conditions of the two groups were compared. Intraoperatively, the pathological structures that related to ED were documented. After surgery, the degree of postoperative ED and functional outcomes were compared between the two groups at 2-year follow-up. RESULTS: The International Knee Documentation Committee subjective score and SF-36 physical component summary scores were worse in the ED group than the non-ED group preoperatively (54 vs 48 [P = 0.014]; 42 vs 39 [P = 0.031], respectively). Intraoperatively, the ED group showed significantly more frequent graft malposition (50% vs 5%), anvil osteophytes (44% vs 0%), and scarring around posterior intercondylar notch (100% vs 0%). However, there was no difference in the degree of postoperative ED and functional outcome between the two groups at follow-up. CONCLUSIONS: ED in patients with recurrent instability after primary ACL reconstruction could be treated with good clinical result by addressing the pathological conditions causing ED in addition to ACL re-reconstruction.


Subject(s)
Anterior Cruciate Ligament Reconstruction , Anterior Cruciate Ligament/surgery , Cartilage, Articular/pathology , Knee Joint/physiopathology , Reoperation , Adolescent , Adult , Female , Humans , Joint Instability/physiopathology , Male , Middle Aged , Range of Motion, Articular , Treatment Outcome , Young Adult
8.
J Bone Joint Surg Am ; 100(9): 735-741, 2018 May 02.
Article in English | MEDLINE | ID: mdl-29715221

ABSTRACT

BACKGROUND: Occasionally, patients experience new or increased ankle pain following total knee arthroplasty (TKA). The aims of this study were to determine (1) how the correction of varus malalignment of the lower limb following TKA affected changes in alignment of the ankle and hindfoot, (2) the difference in changes in alignment of the ankle and hindfoot between patients with and without ankle osteoarthritis (OA), and (3) whether the rate of ankle pain and the clinical outcome following TKA differed between the 2 groups. METHODS: We retrospectively reviewed prospectively collected data of 56 patients (99 knees) treated with TKA. Among these cases, concomitant ankle OA was found in 24 ankles. Radiographic parameters of lower-limb, ankle, and hindfoot alignment were measured preoperatively and 2 years postoperatively. In addition, ankle pain and clinical outcome 2 years after TKA were compared between patients with and without ankle OA. RESULTS: The orientation of the ankle joint line relative to the ground improved from 9.4° of varus to 3.4° of varus, and the valgus compensation of the hindfoot for the varus tilt of the ankle joint showed a 2.2° decrease following TKA. Patients in the group with ankle OA showed decreased flexibility of the hindfoot resulting in less preoperative valgus compensation (p = 0.022) compared with the group without ankle OA. The postoperative hindfoot alignment was similar between the 2 groups because of the smaller amount of change in patients with ankle OA. The group with ankle OA had a higher rate of increased ankle pain (38% compared with 16%) as well as a worse Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (mean of 22.2 compared with 14.2) following TKA. CONCLUSIONS: A considerable proportion of patients who underwent TKA had concomitant ankle OA with reduced flexibility of the hindfoot. These patients experienced increased ankle pain following TKA and a worse clinical outcome. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


Subject(s)
Ankle Joint/physiopathology , Arthralgia/physiopathology , Arthroplasty, Replacement, Knee , Bone Malalignment/complications , Bone Malalignment/physiopathology , Osteoarthritis/complications , Osteoarthritis/physiopathology , Aged , Aged, 80 and over , Ankle Joint/diagnostic imaging , Arthralgia/diagnostic imaging , Bone Malalignment/diagnostic imaging , Female , Humans , Male , Middle Aged , Osteoarthritis/diagnostic imaging , Pain Measurement , Retrospective Studies , Treatment Outcome
9.
Arthroscopy ; 32(4): 552-8, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26821958

ABSTRACT

PURPOSE: To observe changes in fatty infiltration (FI) of the teres minor without tear of the teres minor in a postoperative magnetic resonance imaging and to evaluate the influence of FI of the teres minor in the clinical outcomes of rotator cuff repair. METHODS: Of 816 patients who underwent rotator cuff repair, 51 (6.3%) had FI of the teres minor without tear involvement and 30 cases were available for postoperative magnetic resonance imaging. FI and functional outcome scores were assessed and compared with the control group that had no FI of the teres minor selected by a propensity score matching. RESULTS: FI of the teres minor was observed in various degrees (grade 1 in 9, grade 2 in 9, grade 3 in 6, and grade 4 in 6). The degree of FI was not related to the amount of tendon involvement of a rotator cuff tear (P = .240). All postoperative functional outcome scores (12.6 ± 1.2 months; range, 11-17), including pain visual analog scale, Simple Shoulder Test, and American Shoulder and Elbow Surgeons Score, significantly improved (all P < .001), and there were no significant differences compared with that of the control group. In most of the cases, FI of the teres minor was unchanged (P = .317). CONCLUSIONS: FI of the teres minor without tear involvement can be observed in a rotator cuff tear as a possibly incidental finding of unknown clinical significance. Its cause has not been determined, and it appears that FI of the teres minor does not appear to improve, at least at the 1-year follow-up. Nevertheless, the functional outcomes of the repair were successful in our study; therefore, rotator cuff repair can be performed without a great deal of concern in the presence of FI in the teres minor. LEVEL OF EVIDENCE: Level III, retrospective comparative study.


Subject(s)
Adipose Tissue/pathology , Arthroscopy/adverse effects , Postoperative Complications/pathology , Rotator Cuff/surgery , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Postoperative Complications/rehabilitation , Retrospective Studies , Rotator Cuff/pathology , Rotator Cuff Injuries , Rupture/surgery , Treatment Outcome
10.
BMC Musculoskelet Disord ; 16: 320, 2015 Oct 26.
Article in English | MEDLINE | ID: mdl-26503328

ABSTRACT

BACKGROUND: The number of revision total knee arthroplasties (TKAs) in Asian countries is projected to increase with the rapid growth of primary TKA. We investigated the factors associated with the incidence of revision TKA using a nationally representative database. METHODS: Data collected by the Health Insurance Review Agency of Korea, from 260,068 TKA patients between 2007 and 2012, were used to estimate the incidence rate and cumulative incidence of revision TKA according to age, gender, and hospital TKA and prosthesis manufacturer volume. Age, hospital, and manufacturer volume were categorized into three groups. The incidence rates and cumulative incidences of revision TKA were computed by combining age and gender, and by combining hospital and prosthesis manufacturer volume. RESULTS: Incidence rates per 100,000 person-years were as follows: 1) by age: < 65 years, 447.2; 65-74 years, 363.7; ≥ 75 years, 270.9, 2) by gender: male, 537.8; female, 346.1; 3) by hospital volume (procedures/year): < 20, 536.9; 20-199, 432.3; ≥ 200, 300.1; and 4) by manufacturer volume (prostheses/year): < 1500, 772.3; 1500-3999, 453.9; ≥ 4000, 345.6. The revision TKA incidence rate in young males was significantly higher compared to that in elderly females. The difference in cumulative incidence, between hospitals with an annual volume of < 20 procedures and those with a volume of 20-199 procedures, was reduced for manufacturers with an annual volume of ≥ 4000. Similarly, the difference in cumulative incidence between manufacturers with an annual volume of <1500 prostheses and those with a volume of 1500-3999 prostheses was reduced in hospitals with an annual volume of ≥ 200. CONCLUSION: Revision TKA incidence varied according to age, gender, and hospital and manufacturer volume. This data could inform clinical decisions and healthcare strategies.


Subject(s)
Arthroplasty, Replacement, Knee/statistics & numerical data , Registries , Aged , Female , Humans , Knee Prosthesis/statistics & numerical data , Male , Middle Aged , Reoperation/statistics & numerical data , Republic of Korea
11.
Eur Spine J ; 24(2): 388-95, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25253301

ABSTRACT

INTRODUCTION: There is no comparative study regarding surgical outcomes between microsurgical extraforaminal decompression (MeFD) and posterior lumbar interbody fusion (PLIF) for the treatment of lumbar foraminal stenosis (LFS). Therefore, the purpose of this study was to compare the surgical outcomes of LFS using two different techniques: MeFD alone or PLIF. METHODS: For the purposes of this study, a prospectively collected observational cohort study was conducted. Fifty-five patients diagnosed with LFS who were scheduled to undergo spinal surgery were included in this study. According to the chosen surgical technique, patients were assigned to either the MeFD group (n = 25) or the PLIF group (n = 30). The primary outcome was Oswestry Disability Index (ODI) score at 1 year after surgery. RESULTS: The baseline patient characteristics and preoperative ODI score, visual analog scale (VAS) scores for back and leg pain, and Short Form-36 score were not significantly different between the two groups. At 12 months postoperative, the mean ODI score in the MeFD and PLIF groups was 25.68 ± 14.49 and 27.20 ± 12.56, respectively, and the 95% confidence interval (-9.76-6.73) was within the predetermined margin of equivalence. The overall ODI score and VAS scores for back and leg pain did not differ significantly over the follow-up assessment time between the two groups. However, the ODI score and VAS scores for back and leg pain improved significantly over time after surgery in both groups. In the MeFD group, revision surgery was required in three patients (12%). CONCLUSIONS: This study demonstrated that MeFD alone and PLIF have equivalent outcomes regarding improvement in disability at 1 year after surgery. However, the higher rate of revision surgery in the MeFD group should emphasize the technically optimal amount of decompression.


Subject(s)
Decompression, Surgical/methods , Lumbar Vertebrae , Neurosurgical Procedures/methods , Spinal Stenosis/surgery , Adult , Aged , Cohort Studies , Female , Humans , Lumbar Vertebrae/surgery , Male , Microsurgery , Middle Aged , Minimally Invasive Surgical Procedures , Pain Measurement , Spinal Fusion/methods , Treatment Outcome
12.
Am J Sports Med ; 42(8): 1985-92, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24787044

ABSTRACT

BACKGROUND: Less mature athletes exhibit biomechanical parameters during cutting maneuvers that may place these athletes at greater risk for injury than their more mature counterparts, especially if the maneuvers are unanticipated. However, most studies on risk factors for anterior cruciate ligament (ACL) injury have focused on neuromuscular and knee kinematic differences between the sexes, not on the biomechanical parameters between specific sporting maneuvers. HYPOTHESES: (1) Anticipation will have a greater effect than the type of cutting maneuver (side- vs cross-cutting) in terms of the biomechanical risk factors for ACL injuries, and (2) the biomechanical risk factors will be different between the 2 types of maneuvers. STUDY DESIGN: Controlled laboratory study. METHODS: Thirty-seven young, male middle school soccer players participated in this study. Three-dimensional motion analysis featuring ground-reaction force and electromyography of the right leg was used. Kinematics, kinetics, and electromyography data for each athlete were analyzed during anticipated and unanticipated side- and cross-cutting maneuvers. The differences between anticipated and unanticipated states as well as between side- and cross-cutting maneuvers were calculated and compared. RESULTS: After unanticipated side-cutting, the time to peak ground-reaction force was longer and peak values were smaller compared with anticipated side-cutting. Flexion, valgus, and internal rotations in the knee joint were larger, and greater flexion and valgus moments were observed. The vastus lateralis and vastus medialis showed lower activity, and the lateral gastrocnemius showed higher activity after unanticipated side-cutting maneuvers. With unanticipated cross-cutting, the time to peak ground-reaction force was longer and peak values were smaller compared with anticipated cross-cutting, and the lateral gastrocnemius showed higher activity. Differences in the peak values of the mediolateral and vertical forces were smaller in the cross-cutting maneuver than in side-cutting. Changes in flexion and adduction of the hip joint, flexion of the knee joint, and inversion of the ankle joint were larger during side-cutting. CONCLUSION: Although there were some interactions between direction and anticipation, anticipating a cutting maneuver generally had a greater effect than the type of maneuver when there was no significant interaction. CLINICAL RELEVANCE: Increases in the valgus angle and moment of the knee joint and higher lateral gastrocnemius activity during the late period showed an association with ACL injury risk factors during side-cutting, and higher lateral gastrocnemius activity during the early period showed an association with injury risk factors during cross-cutting.


Subject(s)
Anticipation, Psychological/physiology , Lower Extremity/physiology , Motor Skills/physiology , Soccer/physiology , Soccer/psychology , Adolescent , Anterior Cruciate Ligament Injuries , Biomechanical Phenomena , Electromyography , Humans , Knee Injuries/etiology , Lower Extremity/physiopathology , Male , Muscle, Skeletal/physiology , Range of Motion, Articular , Risk Factors , Rotation , Soccer/injuries , Time and Motion Studies
13.
J Asthma ; 39(4): 307-14, 2002 Jun.
Article in English | MEDLINE | ID: mdl-12095180

ABSTRACT

The aim of this study was to examine the relationship of wheezing to airflow obstruction during acute episodes of asthma in patients who had CVA (Cough variant asthma). Two groups of asthmatic children, one group with a past history of CVA (n = 13) and the other group without such a history (n = 14), were followed longitudinally for 12 months. During that time, they were evaluated for the presence of wheezing and the severity of airflow obstruction during acute episodes of asthma. Significant airflow obstruction occurred free of wheezing more frequently and the presence of clinical wheezing was associated with more severe airflow limitation, in asthmatic patients with a past history of CVA than in those without such a history. We conclude that asthmatic patients who have experienced CVA develop the wheezing symptom at a higher level of airflow obstruction.


Subject(s)
Asthma/complications , Cough/etiology , Pulmonary Disease, Chronic Obstructive/etiology , Respiratory Sounds/etiology , Adolescent , Asthma/physiopathology , Bronchial Provocation Tests/methods , Bronchoconstrictor Agents , Child , Female , Forced Expiratory Volume , Humans , Male , Methacholine Chloride , Severity of Illness Index
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