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Channels (Austin) ; 9(4): 186-95, 2015.
Article in English | MEDLINE | ID: mdl-26083271

ABSTRACT

TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic ß-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.


Subject(s)
Leptin/physiology , Signal Transduction/physiology , TRPC Cation Channels/physiology , ras Proteins/physiology , Amino Acid Sequence , Humans , Ion Channel Gating/physiology , Leptin/metabolism , Models, Biological , Molecular Sequence Data , Sequence Homology, Amino Acid , TRPC Cation Channels/metabolism , ras Proteins/genetics , ras Proteins/metabolism
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