ABSTRACT
BACKGROUND/OBJECTIVE: Oral antifungal agents are the mainstay of the therapy of pediatric tinea capitis. No approved topical medications for tinea capitis are found. We evaluated the therapeutic efficacy, safety, and tolerability of topical 1% encapsulated terbinafine hydrochloride gel for the treatment of pediatric tinea capitis. METHODS: An open-label clinical trial was performed on 10 children with clinical and mycologically confirmed diagnosis of tinea capitis. Each child was prescribed topical 1% encapsulated terbinafine hydrochloride gel to be applied twice daily to the full scalp for 4 weeks. Clinical and mycological examinations were assessed 2 weeks after completion of treatment. Monitoring was performed for associated side effects during the treatment and follow-up periods. RESULTS: Ten male patients were enrolled with a mean age of 10.3 years. A cure rate of 80% (n = 8) was noted 2 weeks after treatment completion. An additional 20% (n = 2) had mycological cure with incomplete, but significant clinical improvement. No significant side effects were reported. CONCLUSIONS: This preliminary study demonstrated that topical 1% encapsulated terbinafine hydrochloride gel was an effective treatment for tinea capitis in children.
Subject(s)
Naphthalenes , Tinea Capitis , Antifungal Agents/adverse effects , Child , Humans , Male , Naphthalenes/adverse effects , Pilot Projects , Terbinafine , Tinea Capitis/drug therapyABSTRACT
Rosai-Dorfminan disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a benign idiopathic proliferative disorder of the histiocyte. Purely Cutaneous Rosai-Dorfman disease (CRDD) is a separated clinical entity without lymph node and organ involvement. The histologic features resemble RDD, but with dermal infiltration. This rare condition is benign and mostly self-limited The authors report a 66-year-old Thai male patient, diagnosed as purely CRDD, with co-existing capillary hemangioma. In addition, we show that the treatment intralesional corticosteroid can produce the remission of the plaque and tumoral types of this condition.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Hemangioma, Capillary/complications , Hemangioma, Capillary/drug therapy , Histiocytosis, Sinus/complications , Histiocytosis, Sinus/drug therapy , Aged , Biopsy , Humans , Immunohistochemistry , Injections, Intralesional , MaleABSTRACT
A 50-year-old Thai woman presented with papulonecrotic tuberculid-like eruptions on her back and inframammary area with fever, nonproductive cough and weight loss. Chest radiograph showed diffuse bilateral reticulonodular opacities in both lungs with bilateral hilar lymph node enlargement. High resolution computed tomography (HRCT) of the lungs showed peribronchovascular interstitial thickening with multiple lymph nodes enlargement. Sputum for AFB was negative. Monotest (PPD) was negative. Skin biopsy revealed multiple naked granuloma compatible with sarcoidosis. She was treated with isoniazid, 300 mg/d, rifamipicin, 600 mg/d, ethambutal, 800, mg/d and pyrazinamide, 1000 mg/d for 2 months without improvement of skin and lung lesions. Prednisolone 45 mg/d was then administered adjunctive with isoniazid and rifampicin. After two weeks of treatment with prednisolone, the cutaneous and pulmonary lesions markedly improved Prednisolone was tapered in 6 months. Skin lesions, fever; dry cough disappeared and chest radiograph, HRCT of the chest were markedly improved.
