1.
Br J Cancer
; 98(8): 1431-3, 2008 Apr 22.
Article
in English
| MEDLINE
| ID: mdl-18349850
ABSTRACT
We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.