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Br J Cancer ; 98(8): 1431-3, 2008 Apr 22.
Article in English | MEDLINE | ID: mdl-18349850

ABSTRACT

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.


Subject(s)
Brain Neoplasms/genetics , Genes, p53 , Glioblastoma/genetics , Mutation , RNA, Messenger/analysis , Tumor Suppressor Protein p53/genetics , Adolescent , Adult , Aged , Female , Humans , Loss of Heterozygosity , Male , Middle Aged , Promoter Regions, Genetic
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