ABSTRACT
Introduction: Sarcopenia is associated with worsened outcomes in solid cancers. Temporalis muscle thickness (TMT) has emerged as a measure of sarcopenia. Hence, this study aims to evaluate the relationship between TMT and outcome measures in patients with malignant intra-axial neoplasms. Method: We searched Medline, Embase, Scopus and Cochrane databases for relevant studies. Event ratios with 95% confidence intervals (CI) were analysed using the RevMan 5.4 software. Where meta-analysis was impossible, vote counting was used to determine the effect of TMT on outcomes. The GRADE framework was used to determine the certainty of the evidence. Results: Four outcomes were reported for three conditions across 17 studies involving 4430 patients. Glioblastoma: thicker TMT was protective for overall survival (OS) (HR 0.59; 95% CI 0.46-0.76) (GRADE low), progression free survival (PFS) (HR 0.40; 95% CI 0.26-0.62) (GRADE high), and early discontinuation of treatment (OR 0.408; 95% CI 0.168-0.989) (GRADE high); no association with complications (HR 0.82; 95% CI 0.60-1.10) (GRADE low). Brain Metastases: thicker TMT was protective for OS (HR 0.73; 95% CI 0.67-0.78) (GRADE moderate); no association with PFS (GRADE low). Primary CNS Lymphoma: TMT was protective for overall survival (HR 0.34; 95% CI 0.19-0.60) (GRADE moderate) and progression free survival (HR 0.23; 95% CI 0.09-0.56) (GRADE high). Conclusion: TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians.
ABSTRACT
INTRODUCTION: The aim of the protocol is to present the methodology of a scoping review that aims to synthesise up-to-date evidence on the management and outcomes of facial nerve palsy in low-income and middle-income countries (LMICs). METHODS AND ANALYSIS: The scoping review will be conducted per the Arksey and O'Malley's framework and the Joanna Briggs Institute Reviewers' Manual. The scoping review question, eligibility criteria and search strategy will be developed in accordance to the Population, Concept, and Context strategy. The search will be conducted in electronic bibliographic databases (Medline (OVID), Embase, WHO Global Index Medicus, Cochrane Library, Global Health, African Journals Online). The review will synthesise and report the findings with descriptive statistics and a narrative description of both quantitative and qualitative evidence. ETHICS AND DISSEMINATION: This scoping review does not require ethical approval. This protocol will describe the proposed scoping review that will map the evidence on the management and outcomes of facial nerve palsies in LMICs. The proposed review aims to collate and summarise published literature to inform policy-makers and healthcare organisations and governments and to identify knowledge gaps that will translate into future research priorities in LMICs.
Subject(s)
Developing Countries , Facial Nerve , Humans , Research Design , Paralysis , Review Literature as TopicABSTRACT
BACKGROUND: Maternal mortality plagues much of the low- and low-middle-income countries. There were 303,000 maternal deaths in 2015, representing an overall global maternal mortality ratio of 216 maternal deaths per 100,000 live births. 99% of all maternal deaths occur in developing countries. The knowledge of antenatal care is an important factor affecting maternal mortality rates. OBJECTIVE: This study aimed to assess the extent of knowledge of antenatal-care services among women of reproductive age in Ido Ekiti, a rural town in South West Nigeria. STUDY DESIGN: This cross-sectional study was conducted among 299 women in the reproductive age group, ie, from the ages of 18 to 49 years. Data were collected with a set of self-administered questionnaires and analyzed using SPSS version 25. This study was conducted in Ido Ekiti, a town in the Ido-Osi local government area. RESULTS: Most respondents were between 31 and 40 years of age. Most respondents (96%) were educated. 95.6% of the participants in this study were aware of antenatal-care services. 98.7% of the respondents acknowledged that weight and height measurements, abdominal examination, blood tests, and administration of folic acids were carried out during antenatal-care visits. 97.3% had excellent knowledge of the service. CONCLUSION: Most respondents were aware of antenatal care and had excellent knowledge of its components. This is indeed a positive finding and is likely because of the high literacy levels, access to electronic media, and the location of 3 public health facilities in the town. Continuous education of women by relevant stakeholders and policymakers on antenatal care should be ensured to maintain the current state and replicate similar findings in other rural areas across Africa.
