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Mar Drugs ; 17(12)2019 Dec 15.
Article in English | MEDLINE | ID: mdl-31847481

ABSTRACT

Three new 11,20-epoxybriaranes-fragilides U-W (1-3), as well as two known metabolites, junceellonoid D (4) and junceellin (5), were obtained from the octocoral Junceella fragilis. The structures of briaranes 1-3 were elucidated by spectroscopic methods and briaranes 3 and 5 displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7.


Subject(s)
Anthozoa/physiology , Diterpenes/metabolism , Animals , Cyclooxygenase 2/metabolism , Cyclooxygenase Inhibitors/pharmacology , Diterpenes/chemistry , Diterpenes/classification , Gene Expression Regulation, Enzymologic/drug effects , Magnetic Resonance Spectroscopy , Mice , Models, Molecular , Molecular Structure , Nitric Oxide Synthase Type II/antagonists & inhibitors , Nitric Oxide Synthase Type II/metabolism , RAW 264.7 Cells
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