Chalcone derivatives and their antibacterial activities: Current development.

The increase in antibiotic resistance due to various factors has encouraged the look for novel compounds which are active against multidrug-resistant pathogens. In this framework, chalcone-based compounds showed a diversity of pharmacological properties, and its derivatives possess a high degree of structural diversity, and it is helpful for the discovery of new therapeutic agents. The growing resistance to antibiotics worldwide has endangered their efficacy. This has led to a surging interest in the discovery of new antibacterial agents. Thus, there is an urgent need for new antibacterial drug candidates with increased strength, new targets, low cost, superior pharmacokinetic properties, and minimum side effects. The present review concluded and focuses on the recent developments in the area of medicinal chemistry to explore the diverse chemical structures of potent antibacterial agents and also describes its structure-activity relationships studies. The various synthetic structures leading to this class of neutral protective compound is common and additional structural optimization is promising for potential drug discovery and development.

Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.

Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of people worldwide and the subsequent epidemiological statistics highlights the implication of the disease. AD is a multi-factorial disease, a variety of single-target directed drugs that have reached clinical trials have unsuccessful. Hence, various factors associated without set of AD have been considered in targeted drug discovery and development. Triazoles are five-membered heterocyclic scaffold due to their broad range of biological activities. The present review focuses on the recent developments in the area of medicinal chemistry to explore the diverse chemical structures of potential inhibitors of Alzheimer's disease and also look at its structure-activity relationships (SAR) studies of bioactive compounds for future discovery of suitable drug candidates. The prominence has been given on the major advancements in the medicinal brochure of this pharmacophore for the period during 2012-2019.

Removal of Pb(II) from wastewater using Al2O3-NaA zeolite composite hollow fiber membranes synthesized from solid waste coal fly ash.

Al2O3-NaA zeolite composite hollow fiber membranes were successfully fabricated via hydrothermal synthesis by using industrial solid waste coal fly ash and porous Al2O3 hollow fiber supports. The as-synthesized Al2O3-NaA zeolite composite hollow fiber membranes were then characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The hollow fiber membranes were used to remove lead ions (Pb(II), 50 mg L-1) from synthetic wastewater with a removal efficiency of 99.9% at 0.1 MPa after 12 h of filtration. This study showed that the Al2O3-NaA zeolite composite hollow fiber membranes (the pore size of the membrane was about 0.41 nm in diameter) synthesized from coal fly ash could be efficiently used for treating low concentration Pb(II) wastewater. It recycled solid waste coal fly ash not only to solve its environment problems, but also can produce high-value Al2O3-NaA zeolite composite hollow fiber membranes for separation application in treating wastewater containing Pb(II).

Polypyrrole Nanotube-Derived Carbon Aerogels as Efficient and Recyclable Oil Absorbents.

Polypyrrole nanotube-derived carbon aerogels with three-dimensional networks have been prepared via freeze-drying and pyrolysis method using polypyrrole nanotubes as precursors. The resulting carbon nanotube aerogels display ultra-low density, fairly high mechanical properties, water repellency, superoleophilicity, high absorption capacity and fast absorption rate of oil and organic solvents. Its absorption capacity can reach in the range from 140 to 600 times of its own weight for the utilized common oil and organic solvents. Furthermore, the carbon nanotube aerogels demonstrate outstanding recyclability by distill or direct combustion in air because of their excellent hydrophobicity and fire-resistant properties. Significantly, the carbon nanotube aerogels maintain 82.2% absorption capacity after 100 absorption/combustion cycles. Our results suggest that the polypyrrole nanotube-derived carbon aerogels are suitable absorbents for a wide range of applications in water environment protection.