[A neonatal intelligent regulation system based on the combination of mild hypothermia mattress and hyperbaric oxygen chamber: introduction to a patent]. / 基于亚低温床垫与高压氧舱结合的新生儿智能调控系统.

Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease that affects brain function in neonates. At present, mild hypothermia and hyperbaric oxygen therapy are the main methods for the treatment of neonatal HIE; however, they are independent of each other and cannot be combined for synchronous treatment, without monitoring of brain function-related physiological information. In addition, parameter setting of hyperbaric oxygen chamber and mild hypothermia mattress relies on the experience of the medical practitioner, and the parameters remain unchanged throughout the medical process. This article proposes a new device for the treatment of neonatal HIE, which has the modules of hyperbaric oxygen chamber and mild hypothermic mattress, so that neonates can receive the treatment of hyperbaric oxygen chamber and/or mild hypothermic mattress based on their conditions. Meanwhile, it can realize the real-time monitoring of various physiological information, including amplitude-integrated electroencephalogram, electrocardiogram, and near-infrared spectrum, which can monitor brain function, heart rate, rhythm, myocardial blood supply, hemoglobin concentration in brain tissue, and blood oxygen saturation. In combination with an intelligent control algorithm, the device can intelligently regulate parameters according to the physiological information of neonates and give recommendations for subsequent treatment.

Single domain antibodies from camel: Research advances / 国际药学研究杂志

Camelidae possess special type of antibody, namely heavy-chain antibody. It consists of a homodimer comprising three domains: CH2, CH3 and one variable region of heavy chain (VH), but CH1 and light chain are absent. The VH of heavy-chain antibody is named nanobody. Compared to the traditional antibody, nanobody has many advantages. For example it has small molecular weight, better stability and can cross blood brain barrier(BBB). More and more application of nanobodies have been reported in scientific fields, such as biological detection, diagnosis, and pharmacy. In this paper we review structural characteristics and physicochemical properties of nanobodies, and investigate their development in biomedicine researches as well.