1.
Org Biomol Chem
; 20(34): 6923-6930, 2022 08 31.
Article
in English
| MEDLINE
| ID: mdl-35979893
ABSTRACT
An effective synthetic method for 1,3,5-trisubstituted pyrazoles via 1,3-dipolar cycloaddition reaction has been developed. This reaction could smoothly proceed between ninhydrin-derived Morita-Baylis-Hillman carbonates and nitrilimines to provide a wide scope of differently substituted pyrazoles in high yields (up to 95%). In addition, the reaction mechanism was also proposed to explain its regioselectivity.