Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss.

Objectives: Changes in coagulation indexes, thromboelastogram(TEG) and autoantibodies in patients with recurrent pregnancy loss (RPL) with different number of abortions were analyzed. Methods: Medical records of 48 patients with recurrent abortion, treated in Quzhou people's Hospital from November 2019 to October 2020, were collected as the observation group. Based on the number of abortions, patients were divided into Group-A (Two abortions, n=21), Group-B (Three abortions, n=16) and group C (Abortion ≥ four times, n=11). Records of 50 healthy pregnant women in our hospital in the same period were selected as the control group. Coagulation indexes [prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB), D-Dimer (DD)], thromboelastogram (TEG) parameters [reaction time (R), coagulation time(K), maximum thrombus amplitude (MA), coagulation angle (α)], changes in the levels of autoantibodies [anticardiolipin antibody (ACA), anti-endometrial antibody (EmAb), anti-thyroid antibody(ATA)] were compared between the groups. Results: There were significant differences in the levels of ATPP, Pt, FIB and DD among the groups. Higher number of abortions correlated with lower the levels of ATPP and Pt, and higher levels of FIB and DD (P<0.05). Compared to the control group, R and K in Group-A,B and C decreased, while α and MA increased (P<0.05). There were significant differences in α and MA indexes. The positive rates of ACA, EmAb and ATA in Group-A were higher than those in the control group, but the difference was not statistically significant (P>0.05), while the above indexes in groups B and C were significantly higher than those in the control group (P<0.05). The positive rates of ACA and ATA in group C were significantly higher than those in Group-A (P<0.05), but there was no significant difference in the positive rate of EmAb (P>0.05). Conclusion: RPL was related to the decrease of APTT, PT, and the increase of FIB and DD levels. TEG indicated that the increase of α and MA values indicated that the risk of multiple abortion was increased. The positive rates of ACA, EmAb and ATA were closely related to multiple abortions, especially the positive rates of ACA and ATA.

Chorioretinal Alterations Induced by Preeclampsia.

Hypertension during pregnancy, which is essentially a microvascular disease that destroys the end-organ microcirculation, should not be underestimated, as it could lead to organ failure in the kidneys, lungs, and brain. Preassessment of the microcirculatory state through systematic observation of the fundus has been proven to be noninvasive and feasible. Although hypertension in preeclampsia patients will resolve after childbirth, the sticking point is determining the best termination moment. Early diagnosis and treatment can prevent long-term ocular complications and cardiovascular risks for pregnant women in the future. In order to adjust the treatment strategy through more sensitive and precise fundus changes, we comprehensively summarized the common structural changes in the fundus in preeclampsia patients, including changes in the blood vessels, choroid, and retina, as well as the application of quantitative observation for chorioretinal alterations in recent years.

Mn-Ce-Co complex oxide nanoparticles: hydrothermal synthesis and their catalytic subcritical oxidation of 4,4'-Dibromobiphenyl.

In situ transformation of 4,4'-Dibromobiphenyl (4,4'-DBB) in water was observed with hydrothermal diamond anvil cell (HDAC) up to 633 K. It shows that 4,4'-DBB dissolves in water to form a homogenous phase at the temperature of 588 K and thus subcritical water oxidation of 4,4'-DBB higher than the temperature can be a homogenous phase. To accelerate the oxidative degradation, some Mn-Ce-Co complex oxide nanoparticles of about 100 nm were prepared by co-precipitation hydrothermal method. The nanoparticles show enough stability and catalytic activity for oxidative degradation of 4,4'-DBB in subcritical water. The catalytic activation increases with some Co doping and as for the complex oxides of Mn(1)Ce(1), Mn(0.9)Ce(1)Co(0.1), Mn(0.5)Ce(1)Co(0.5), Mn(0.1)Ce(1)Co(0.9), and Co(1)Ce(1), the Mn(0.9)Ce(1)Co(0.1) presents the best activation. The main intermediate products of degradation are benzoic acid and phenol. The apparent activation energy (E(a)) is 35.92 with 5% Mn(0.9)Ce(1)Co(0.1) as catalyst and 46.69 kJ/mol with no catalyst about the chemical oxygen demand (COD).

Ultraviolet light absorption of an ophthalmic formulation with Aloe extracts.

Aloin and polysaccharide present in extracts of Aloe arborescens Miller were formulated into a binary solution to protect eyes from bacterial infection and ultraviolet radiation (UVR). The UVR absorption spectrum was recorded from 190 to 440 nm using a UV spectrometer. The physical properties of the product were examined in terms of its appearance, odor, pH, viscosity, density, refractive index, and stability. The binary solution exhibited three absorption peaks in the UVA, B and C regions, respectively. Such UV absorption capability was attributed to the phenolic chromophores pertaining to aloin. The present study suggested that the formulated binary solution has potential application as an UV absorption agent with built-in antimicrobial activity.