Micro-Electro-Mechanical Systems Microphones: A Brief Review Emphasizing Recent Advances in Audible Spectrum Applications.

The MEMS microphone is a representative device among the MEMS family, which has attracted substantial research interest, and those tailored for human voice have earned distinct success in commercialization. Although sustained development persists, challenges such as residual stress, environmental noise, and structural innovation are posed. To collect and summarize the recent advances in this subject, this paper presents a concise review concerning the transduction mechanism, diverse mechanical structure topologies, and effective methods of noise reduction for high-performance MEMS microphones with a dynamic range akin to the audible spectrum, aiming to provide a comprehensive and adequate analysis of this scope.

Effects of Climate Change Knowledge on Adolescents' Attitudes and Willingness to Participate in Carbon Neutrality Education.

The achievement of carbon neutrality has become increasingly important. Therefore, it the use of education to increase public understanding of carbon neutrality and facilitate low-carbon behaviors is urgent. Climate change knowledge is an effective measure to promote people's interest and enthusiasm for specific educational projects. The present study analyzed the effects of climate change knowledge on adolescents' attitudes and their willingness to participate in carbon neutrality education and validated the mediating effect of environmental responsibility. The findings showed that climate change knowledge improves adolescents' attitudes toward carbon neutrality education and that environmental responsibility plays a mediating role in this. The findings provide insightful implications for carbon neutrality related policymaking and education promotion.

The Impact of the Gain-Loss Frame on College Students' Willingness to Participate in the Individual Low-Carbon Behavior Rewarding System (ILBRS): The Mediating Role of Environmental Risk Perception.

Since Chinese households account for more than half of the country's total carbon emissions, efforts focused on consumption will be key to reaching carbon reduction targets. The Individual Low-carbon Behavior Rewarding System (ILBRS) is an emerging mechanism in China that encourages the public to develop a low-carbon lifestyle and it is critical to look for various approaches to enhance the public's willingness to participate in it. The framing effect has been widely used to study pro-environmental behavior as a low-cost nudge. We used an online questionnaire (N = 320) to investigate how framing information (loss and gain framing) influenced people's willingness to participate in the ILBRS through the mediation of environmental risk perception. The results indicated that the public's willingness to participate in the ILBRS under the loss frame was significantly higher than the gain frame. Furthermore, environmental risk perception played a mediating role in the proceedings. Based on our findings, the designers and promoters of ILBRS systems could employ loss-frame information to promote the public's willingness to participate in the ILBRS and drive more people to live a low-carbon life in the process of mechanism construction, information communication, and operational promotion.

LINC00922 acts as a novel oncogene in gastric cancer.

BACKGROUND: Long non-coding RNAs (lncRNAs) have been discovered to participate in various cancer developments. However, the biological function of lncRNAs associated with gastric cancer (GC) has not been fully elucidated. METHODS: Quantitative RT-PCR (qRT-PCR) assay was performed to measure lncRNAs, microRNAs (miRNAs) and message RNA (mRNA) expression. Cell Counter Kit-8 (CCK-8), clone formation, wound healing, and transwell assays were performed to investigate cell proliferation, migration, invasion, and apoptosis. Fluorescence in situ hybridization (FISH) assay was used to analyze LINC00922 in either the cytoplasm or nucleus. The potential binding among lncRNA, miRNA, and mRNA was evidenced by bioinformatics, luciferase reporter assay. Mouse-xenograft experiments were used to explore the tumorigenesis in vivo. RESULTS: LINC00922 was upregulated in GC, and high LINC00922 expression was associated with poor prognosis. Inhibition of LINC00922 suppressed GC cell proliferation, migration, invasion, and activated cell apoptosis in vitro and inhibited tumorigenesis in vivo. Besides, LINC00922 was markedly located in the cytoplasm. The mechanistic analysis demonstrated that LINC00922 acted as a sponge of miR-204-5p, thereby inhibiting the expression of the target gene-High Mobility Group AT-hook 2 (HMGA2). CONCLUSION: LINC00922 accelerated the progression of GC by miR-204-5p/HMGA2 axis. These findings support LINC00922 may be a promising option for the diagnosis and therapy of GC.

Deploying and scaling distributed parallel deep neural networks on the Tianhe-3 prototype system.

Due to the increase in computing power, it is possible to improve the feature extraction and data fitting capabilities of DNN networks by increasing their depth and model complexity. However, the big data and complex models greatly increase the training overhead of DNN, so accelerating their training process becomes a key task. The Tianhe-3 peak speed is designed to target E-class, and the huge computing power provides a potential opportunity for DNN training. We implement and extend LeNet, AlexNet, VGG, and ResNet model training for a single MT-2000+ and FT-2000+ compute nodes, as well as extended multi-node clusters, and propose an improved gradient synchronization process for Dynamic Allreduce communication optimization strategy for the gradient synchronization process base on the ARM architecture features of the Tianhe-3 prototype, providing experimental data and theoretical basis for further enhancing and improving the performance of the Tianhe-3 prototype in large-scale distributed training of neural networks.

Over-expression of small ubiquitin-related modifier-1 and sumoylated p53 in colon cancer.

Here we investigated whether the cellular accumulation of p53 protein caused by over-expression of small ubiquitin-related modifier-1 (SUMO-1) could be used as a predictive marker for prognosis in colon cancer. We detected SUMO-1 and p53 protein levels in 46 cases of colon cancer and adjacent tissues by immunohistochemistry and found that SUMO-1 was expressed at much higher levels in colon cancer compared with that in normal colon tissue. Immunoprecipitation and Western blot analysis revealed that the tumor suppressor p53 was present predominantly in the sumoylated rather than the non-sumoylated form in the colon cancer cell lines. A small interfering RNA targeted to SUMO-1 mRNA sequences was used to observe the levels of the p53 protein. Patients who showed high dual expressions of SUMO-1 and p53 tended to experience metastasis more frequently. These results suggest that the cellular accumulation of p53 protein caused by over-expression of SUMO-1 may be involved in tumor aggressiveness. Multivariate analysis confirmed that the high dual expression of SUMO-1 and p53 was an independent factor for evaluating prognosis. SUMO-1 may be useful as a novel target for therapy in colon cancer as well as a clinical indicator for tumor aggressiveness.

Mitochondrial uncoupling protein 2 expression in colon cancer and its clinical significance.

AIM: To detect the expression of mitochondrial uncoupling protein 2 (UCP2) in colon cancer and analyze the relation between UCP2 expression and clinical pathological features of colon cancer. METHODS: Fifteen colon tissue samples and 15 its adjacent tissue samples were obtained from colon cancer patients during surgical interventions. UCP2 expression was detected with immunohistochemical method in 10 normal controls, 10 hyperplastic polyp patients, 20 tubular adenoma patients and 78 colon cancer patients. Patients with rectal cancer were excluded. Quantitative reverse transcription polymerase chain reaction and Western blotting were used to detect UCP2 expressions in colon cancer tissue samples and its adjacent tissue samples. Relation between UCP2 expression and clinical pathological features of colon cancer was also analyzed. RESULTS: The UCP2 mRNA expression level was four-fold higher in colon cancer tissue samples than in its adjacent tissue samples. The UCP2 protein expression level was three-fold higher in colon cancer tissue samples than in its adjacent normal tissue samples. The UCP2 was mainly expressed in cytoplasm. The UCP2 was not expressed in normal colon mucosa. Strong positive staining for UCP2 with a diffuse distribution pattern was identified throughout the mucosa in colon cancer tissue samples with a positive expression rate of 85.9%. The UCP2 expression level was higher in colon cancer tissue samples at clinical stages III and IV than in those at stage I + II. Univariate analysis showed that the high UCP2 expression level was significantly correlated to colon cancer metastasis (hazard ratio = 4.321, confidence interval = 0.035-0.682, P = 0.046). CONCLUSION: UCP2 is highly expressed in human colon cancer tissue and may be involved in colon cancer metastasis.