ABSTRACT
OBJECTIVE: To investigate the preliminary clinical effect of closed reduction and cannulated nail internal fixation for femoral neck fracture assisted by robot navigation and positioning system. METHODS: From July 2019 to January 2020, 16 cases of femoral neck fracture ï¼navigation groupï¼ were treated with closed reduction and internal fixation guided by robot system, including 7 males and 9 females, aged 25 to 72 years old with an average of ï¼53.61±5.45ï¼ years oldï¼Garden classification of fractureï¼3 cases of typeâ , 3 cases of typeâ ¡, 8 cases of type â ¢, 2 cases of type â £. Non navigation group ï¼control groupï¼ï¼20 cases of femoral neck fracture were treated with closed reduction and hollow nail internal fixation, 8 males and 12 females, aged 46 to 70 years old with an average of ï¼55.23±4.64ï¼ years oldï¼Garden typeâ in 2 cases, typeâ ¡in 4 cases, type â ¢ in 11 cases, type â £ in 3 cases. The operation time, fluoroscopy times, guide needle drilling times, screw adjustment times, intraoperative bleeding volume and other indicators of two groups were evaluated. RESULTS: Both groups were followed up for 12 to 18 months with an average of ï¼15.6±2.8ï¼ months. The fractures of both groups were healed without delayed union and nonunion. There was no significant difference in healing time between two groupsï¼P=0.782ï¼. There was no significant difference in Harris scores between two groups at the last follow-upï¼P=0.813ï¼. There was no significant difference in operation time between two groupsï¼P>0.05ï¼. There were significant differences between two groups in fluoroscopy times, guide needle drilling times, hollow screw replacement times, and intraoperative bleeding volumeï¼P<0.05ï¼. CONCLUSION: Closed reduction and hollow screw internal fixation assisted by robot navigation system for femoral neck fracture has the advantages of minimally invasive operation, precise screw placement, and reduction of X-ray radiation damage during operation.
Subject(s)
Femoral Neck Fractures , Orthopedics , Robotics , Male , Female , Humans , Adult , Middle Aged , Aged , Treatment Outcome , Femoral Neck Fractures/surgery , Bone Screws , Fracture Fixation, Internal , Fracture Healing , Retrospective StudiesSubject(s)
Arthroplasty, Replacement, Knee , Joint Dislocations , Knee Prosthesis , Osteoarthritis, Knee , Humans , Arthroplasty, Replacement, Knee/adverse effects , Knee Joint/surgery , Knee Prosthesis/adverse effects , Joint Dislocations/etiology , Osteoarthritis, Knee/surgery , Prosthesis Design , Prosthesis Failure , Treatment OutcomeABSTRACT
Osteoarthritis (OA) poses a growing threat to the health of the global population. Accumulation of advanced glycation end-products (AGEs) has been shown to upregulate expression of degradative enzymes such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in chondrocytes, which leads to excessive degradation of type II collagen and aggrecan in the articular extracellular matrix (ECM). In the present study we investigated the effects of the GLP-1 agonist lixisenatide, a widely used type II diabetes medication, on AGEs-induced decreased mitochondrial membrane potential (MMP), degradation of ECM, oxidative stress, expression of cytokines including interleukin (IL)-1ß and IL-6, and activation of nuclear factor kappa B (NF-κB). Our findings indicate that lixisenatide significantly ameliorated the deleterious effects of AGEs in a dose-dependent manner. Thus, lixisenatide has potential as a safe and effective treatment for OA and other AGEs-induced inflammatory diseases.
Subject(s)
Chondrocytes/cytology , Extracellular Matrix/drug effects , Extracellular Matrix/metabolism , Glycation End Products, Advanced/pharmacology , Peptides/pharmacology , ADAMTS4 Protein/metabolism , ADAMTS5 Protein/metabolism , Chondrocytes/drug effects , Collagen Type II/metabolism , Down-Regulation/drug effects , Humans , Interleukin-6/metabolism , Matrix Metalloproteinase 13/metabolism , Matrix Metalloproteinase 3/metabolism , Membrane Potential, Mitochondrial/drug effects , MicroRNAs/genetics , NF-kappa B/metabolism , Oxidative Stress/drug effects , Phosphatidylinositol 3-Kinases/metabolism , Proto-Oncogene Proteins c-akt/metabolism , Tumor Necrosis Factor-alpha/metabolism , Wnt Signaling Pathway/drug effectsABSTRACT
OBJECTIVE: A systematic review and meta-analysis were used to directly evaluate the direct anterior approach (DAA) and the posterior approach (PA) for early efficacy and safety of total hip arthroplasty (THA). METHODS: Control-led trials assessing DAA and PA for the efficacy and safety of THA were searched in the database. Articles were reviewed according to predetermined inclusion and exclusion criteria; the quality of the methodology included in a given study was strictly assessed before data extraction. Moreover, meta-analysis was performed for outcomes that can be combined; otherwise, descriptive analysis was performed. RESULTS: There were 20 articles included, with a total of 7377 patients. Among these, 3728 and 3649 cases were in the DAA and PA groups, respectively. There was no difference between the DAA and PA groups at postoperative week 2 in the number of patients using the assistive ambulatory device or in time needed to completely discontinue all assistive ambulatory devices. Descriptive analysis found that DAA was slightly better than PA regarding early functional recovery and activity after surgery, as well as postoperative pain relief. Hospitalisation stay in the DAA group was shorter than in the PA group, in which the patients had a shorter operative time. Radiographic outcomes showed that there was little difference in prosthetic position between the DAA and PA groups. The proportions of intraoperative fractures and postoperative lateral cutaneous nerve of the thigh (LCNT) neuropraxia were significantly higher in the DAA group than in patients who underwent PA. CONCLUSION: Compared with PA, DAA presents superior early recovery following THA.
