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1.
BMC Womens Health ; 24(1): 345, 2024 Jun 15.
Article in English | MEDLINE | ID: mdl-38877551

ABSTRACT

BACKGROUND: The prognosis of advanced ovarian cancer is often poor. Although there are several treatment options for stage IV epithelial ovarian cancer, it is not clear which treatment will benefit the patient's prognosis.We conducted an analysis using the SEER database to compare the impact of different treatment modalities on the prognosis of advanced ovarian cancer. METHODS: The present study conducts a retrospective analysis of relevant data from the SEER database pertaining to patients diagnosed with stage IV epithelial ovarian cancer between 2011 and 2020 (n = 5345). Statistical methods including Kaplan-Meier curves, log-rank tests, and Cox regression analysis are employed to ascertain the impact of different treatment regimens on the prognosis of patients with stage IV epithelial ovarian cancer. RESULTS: Among patients with stage IV epithelial ovarian cancer, age ≥ 60 and the presence of lung metastases or multiple metastases were identified as poor prognostic factors. Conversely, being Asian or Pacific Islander, married, and testing negative for CA125 were associated with favorable prognoses. In terms of the choice of treatment for patients, surgery plus chemotherapy was the best treatment modality, and timely surgery could significantly improve the prognosis of patients, but there was no difference between chemoradiotherapy alone and the surgery group among patients with lung metastases. CONCLUSION: The prognosis of patients with stage IV epithelial ovarian cancer is influenced by many factors. In terms of the choice of treatment, patients with surgery plus chemotherapy have the best prognosis. In cases where lung metastases are inoperable, a combination of radiotherapy and chemotherapy can be used. In other cases, radiotherapy does not improve outcomes in patients with stage IV epithelial ovarian cancer. This study provides a basis for the choice of treatment for patients with stage IV epithelial ovarian cancer.


Subject(s)
Carcinoma, Ovarian Epithelial , Neoplasm Staging , Ovarian Neoplasms , SEER Program , Humans , Female , Carcinoma, Ovarian Epithelial/therapy , Carcinoma, Ovarian Epithelial/pathology , Carcinoma, Ovarian Epithelial/mortality , Middle Aged , Ovarian Neoplasms/therapy , Ovarian Neoplasms/pathology , Retrospective Studies , Prognosis , Aged , Adult , Combined Modality Therapy , Databases, Factual , Kaplan-Meier Estimate , United States/epidemiology
2.
Curr Med Sci ; 43(4): 794-802, 2023 Aug.
Article in English | MEDLINE | ID: mdl-37498408

ABSTRACT

OBJECTIVE: Histone modification has a significant effect on gene expression. Enhancer of zeste homolog 2 (EZH2) contributes to the epigenetic silencing of target chromatin through its roles as a histone-lysine N-methyltransferase enzyme. The development of anoikis resistance in tumor cells is considered to be a critical step in the metastatic process of primary malignant tumors. The purpose of this study was to investigate the effect and mechanism of anoikis resistance in ovarian adenocarcinoma peritoneal metastasis. METHODS: In addition to examining EZH2 protein expression in ovarian cancer omental metastatic tissues, we established a model of ovarian cancer cell anoikis and a xenograft tumor model in nude mice. Anoikis resistance and ovarian cancer progression were tested after EZH2 and N6-methyladenosine (m6A) levels were modified. RESULTS: EZH2 expression was significantly higher in ovarian cancer omental metastatic tissues than in normal ovarian tissues. Reducing the level of EZH2 decreased the level of m6A and ovarian cancer cell anoikis resistance in vitro and inhibited ovarian cancer progression in vivo. M6a regulation altered the effect of EZH2 on anoikis resistance. CONCLUSION: Our results indicate that EZH2 contributes to anoikis resistance and promotes ovarian adenocarcinoma abdominal metastasis by m6A modification. Our findings imply the potential of the clinical application of m6A and EZH2 for patients with ovarian cancer.


Subject(s)
Adenocarcinoma , Ovarian Neoplasms , Peritoneal Neoplasms , Animals , Female , Humans , Mice , Adenocarcinoma/pathology , Anoikis/genetics , Carcinoma, Ovarian Epithelial/genetics , Cell Line, Tumor , Enhancer of Zeste Homolog 2 Protein/genetics , Enhancer of Zeste Homolog 2 Protein/metabolism , Mice, Nude , Ovarian Neoplasms/pathology , Peritoneal Neoplasms/genetics , Peritoneal Neoplasms/secondary
3.
Adv Mater ; 27(24): 3654-60, 2015 Jun 24.
Article in English | MEDLINE | ID: mdl-25960040

ABSTRACT

Graphene oxide (GO) fractionation is achieved by size-exclusive passing of GO sheets through size-defined pores of track-etched membranes, which separate the GO sample into three portions with narrow size distributions. The method reported can be used for the performance improvement of graphene-based materials.

4.
Article in Chinese | MEDLINE | ID: mdl-15340509

ABSTRACT

BACKGROUND: The study was designed to investigate the status of molecular epidemiology of HCMV in Urumqi through genetic comparison of clinical isolates. METHODS: DNA sequences of 2.0-2.6 kb were amplified by polymerase chain reaction from three relatively conservative gene regions (DNA polymerase, glycoproteins H, and major immediate-early antigen) of 28 clinical HCMV strains and then were analysed by restriction enzymes. RESULTS: The restriction patterns of the clinical isolates which did not have relation in epidemiology were greatly different, but the patterns of the clinical isolates related in epidemiology such as strains paired in mother and infant were quite similar. Of eight mother and infant pairs, from whom HCMV were isolated, four pairs showed identity of restriction profiles within each pair for all three amplified regions, four pairs showed differences between mother and infant. CONCLUSION: These results confirm the high degree of genetic variability among cytomegalovirus strains in Urumqi. Analysis of PCR-RFLP can indicate transmission of HCMV infection and facilitate its molecular epidemiologic studies.


Subject(s)
Cytomegalovirus/genetics , Polymerase Chain Reaction/methods , Polymorphism, Restriction Fragment Length , China/epidemiology , Cytomegalovirus/isolation & purification , Cytomegalovirus Infections/epidemiology , Cytomegalovirus Infections/virology , DNA-Directed DNA Polymerase/genetics , Humans , Immediate-Early Proteins/genetics , Viral Envelope Proteins/genetics
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