ABSTRACT
Objective:To investigate the expression of BRCA1 associated proteinï¼BRAPï¼ and its correlations with clinicopathological features and prognosis of patients with laryngeal squamous cell carcinomaï¼LSCCï¼. Method:The protein expression of BRAP in LSCC tissues and normal laryngeal tissues were assessed by immunohistochemistry and Western blot, and their correlations with clinicopathological features and prognosis were statistically analyzed. Result:The expression of BRAP in LSCC was significantly higher than that in normal laryngeal tissuesï¼P<0.05ï¼. BRAP expression was significantly correlated with the TNM stage and lymph node metastasisï¼P<0.05ï¼. Kaplan-Meier survival analysis showed that LSCC patients with high BRAP expression had worse overall survival than those with low BRAP expressionï¼P<0.01ï¼. Multivariate Cox proportional-hazards analysis showed that the high expression of BRAP protein was an important poor prognostic indicator of the patients. Conclusion:BRAP is related with the development of LSCC, and it may be used as an important prognostic biomarker for LSCC patients.
