ABSTRACT
Coronavirus disease 2019 (COVID-19) continuously proceeds despite the application of a variety of vaccines. It is still urgent to find effective ways to treat COVID-19. Recent studies indicate that NRP1, an important receptor of the natural peptide tuftsin, facilitates SARS-CoV-2 infection. Importantly, tuftsin is a natural human molecule released from IgG. Here, we found 91 overlapping genes between tuftsin targets and COVID-19-associated genes. Bioinformatics analyses indicated that tuftsin could also target ACE2 and exert some immune-related functions to treat COVID-19. Using surface plasmon resonance (SPR) analysis, we confirmed that tuftsin can bind ACE2 and NRP1 directly. Moreover, tuftsin effectively impairs the binding of SARS-CoV-2 S1 to ACE2. Thus, tuftsin is an attractive drug against COVID-19. And tuftsin as natural immunostimulating peptide in human, we speculate that tuftsin may has crucial roles in asymptomatic carriers or mild cases of COVID-19.
ABSTRACT
Along with the degree of population ageing worse off continuously, the demand for medical service is growing. The current system of pension service and medical service are discrete and separate, and integrating pen-sion service with medical service is the best choice for China. However, there are some problems with the model for integrating pension service with medical service. These problems include the lack of funding, negative participation and imperfect methods of service delivery; high toll levels and single, rigid service contents; and bull management and policies hard to enforce. China should improve the service delivery model, identify service content according to the demand for service object, and improve the mechanism of government management.
ABSTRACT
Objective:To promote the development of private pension institutions and social welfare in China. Methods:33 private pension institutions and 165 elderly people are followed with questionnaire. Results:The number of institutions, beds and occupancy in Hefei has increased annually since 2001. 94% of pension institutions are in the mid-range level of 500~1000 yuan;27. 27% of pension institutions belong to self-constructed housing, 69. 7%rented housing, 3. 03% modificated housing. 21. 21% of pension institutions’ investments scale is more than 10 million yuan. Conclusion:Private pension institutions face some problems, such as structural imbalance in terms of supply and demand, shortage of funds, and lack of human resources. Suggestion:We should reasonably adjust the level and function of institutions, increase the support for funds, and cultivate professional teams.
