ABSTRACT
OBJECTIVE: To systematically review the efficacy and safety of taxane, cisplatin, and fluorouracil (Tax-PF) as induction chemotherapy for advanced head and neck cancer. METHOD: Literature about the efficacy and safety of Taxane-cisplatin-fluorouracil as induction chemotherapy for advanced head and neck cancer was retrieved from digital databases of PubMed, Embase, SpringerLink, MEDLINE and the Cochrane Library before February 2015. Data extraction and quality assessment of included studies were conducted by two reviewers independently. Stata 13.0 was then used to perform Meta-analysis. RESULT: A total 7 randomized controlled trials involving 2,702 were included. The 3-year OS rate [HR = 1.14, 95% CI (1.03, 1.25), P < 0.01], 3-year PFS rate [HR = 1.24, 95% CI (1.08, 1.43), P < 0.01], 5-year OS rate [HR = 1.30, 95% CI (1.09, 1. 55), P < 0. 01], 5-year PFS rate [HR = 1.39, 95% CI (1.14, 1.70), P < 0.01] and ORR to chemotherapy [OR = 1.66, 95% CI (1.35, 2.05), P < 0.01] of the patients in the Tax-PF group were statistically superior to those in the PF group. In terms of toxicities, the incidence of febrile neutropenia [OR = 2.36, 95% CI (1.62, 3.46), P < 0.01], alopecia [OR = 8.22, 95% CI (3.99, 16.92), P < 0.01], diarrhea [OR = 1.57, 95% CI (1.05, 2.36), P< 0.05] and leucopenia [OR = 2.79, 95% CI (1.86, 4.21), P < 0.01] was higher in the Tax-PF group than that in the PF group. CONCLUSION: The Tax-PF induction chemotherapy improved PFS and OS, and the ORR was better as compared to PF-based therapy regimens at the cost of a higher incidence of adverse events.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Head and Neck Neoplasms/drug therapy , Induction Chemotherapy , Bridged-Ring Compounds/therapeutic use , Cisplatin/therapeutic use , Fluorouracil/therapeutic use , Humans , Randomized Controlled Trials as Topic , Taxoids/therapeutic useABSTRACT
OBJECTIVE: To explore the clinical character of nasociliary neuralgia and improve the level of diagnosis and treatment. METHOD: Forty-three cases with nasociliary neuralgia were diagnosed and treated in our hospital. The clinical data were analyzed retrospectively. RESULT: It was easy to be misdiagnosed for nasociliary neuralgia,the rate of misdiagnosis was 69.8% (30/43). Performing the resection of upper nasal septum deviation, partial middle turbinetectkomy or/and folded, 43 cases were followed up from 6 to 24 months,the cural rate and the improve rate were 95.3% and 4.7% respectively, with the total effective rate 100.0%. CONCLUSION: Most patients with nasociliary neuralgia are middle-aged women. It is similar to ethmoid sinusitis and frontal sinusitis in headache, but no suppurative rhinorrhea. Careful examination of nasal cavity and CT scan in sinus play an important role in avoiding misdiagnosis. The corrective surgery of middle turbinate and nasal septum are effective treatment and the complication of dysosmia can be avoided.
