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2.
Article in English | MEDLINE | ID: mdl-34847027

ABSTRACT

Droplet injection methods are widely used in the applications of microelectronic manufacturing, biological engineering, and 3-D printing. This work presents a new jet dispenser driven by a single piezoelectric stack that enables the capability of drop-on-demand patterning under a high working frequency (500 Hz). Due to the special designs of the jet dispenser, a broad range of liquids, whose viscosities span more than four orders of magnitude (21-665 320 cps), can be jetted. Moreover, a coupled Coulomb damping physical model is proposed, which includes an electromechanical and a dynamic model. Both the Coulomb and the fluid-solid damping are considered in the dynamic model. In order to validate the results obtained by using MATLAB/Simulink, the experiments were carried out. The injection performance of this jet dispenser has been tested by employing a self-made jetting platform. The minimum volume of a jetting droplet is about 14.4 nL with liquid wax. The error of volume uniformity among droplets does not exceed 8%, and the error of angle trajectory is about 0.17°. Furthermore, the versatility of the jet dispenser is demonstrated by printing liquid lubricant, food, glue, silver past, and a ceramic slurry in predefined patterns.


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Printing, Three-Dimensional
3.
Oncol Lett ; 19(3): 1806-1814, 2020 Mar.
Article in English | MEDLINE | ID: mdl-32194674

ABSTRACT

MicroRNA (miRNAs) serve key roles in the progress of various types of cancer. The expression of miRNA (miR)-139-5p is downregulated in several types of tumor and has been recognized as a tumor suppressor. However, the role of miR-139-5p in non-small cell lung cancer (NSCLC) has not been investigated in detail. In the present study, it was demonstrated that miR-139-5p was significantly downregulated in NSCLC cells and tissues, and the overexpression of miR-139-5p in vitro induced apoptosis and significantly inhibited the viability and proliferation of A549 and H1299 cells. In addition, upregulation of miR-139-5p significantly inhibited the migration and invasion of A549 and H1299 cells. Hepatoma-derived growth factor (HDGF) was identified as a direct target of miR-139-5p. Rescue experiments demonstrated that the inhibitory function of miR-139-5p on cell viability, migration and invasion was partially mediated by suppressing HDGF expression. Furthermore, miR-139-5p exhibited efficient inhibition of tumor growth in a xenograft tumor mouse model of A549 cells. In summary, the results from the present study suggested that miR-139-5p may serve an important role in NSCLC by targeting HDGF and causing inhibition of cell viability and metastasis, as well as induction of apoptosis. miR-139-5p may also have the potential to serve as a therapeutic target for the treatment of NSCLC.

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