ABSTRACT
OBJECTIVE: To evaluate the applicability of immune-related response criteria (irRC) in treating non-small cell lung cancer (NSCLC) by Chinese medicine (CM). METHODS: Totally 97 stage III a-IV NSCLC patients were predominantly treated with comprehensive CM. Curative effects were evaluated by three methods such as Response Evaluation Criteria in Solid Tumors (RECIST), Oncologic Curative Effect Evaluation Criteria of Chinese Medicine in Solid Tumor (draft, abbreviated as CM criteria), and irRC. The correspondency and consistency between irRC, RECIST and CM criteria were analyzed and compared. The objectivity of irRC in evaluating curative effect of Chinese medical treatment for NSCLC was assessed. RESULTS: The correspondency rate of irRC to RECIST was 59. 79% with Kappa value of 0. 379 (U test, P <0. 01). The two criteria had certain correspondence, but with an unsatisfactory consistency. The correspondency rate of irRC to CM criteria rate was 83. 51% with Kappa value of 0.751 (U test, P <0. 01). The two criteria had good correspondence and consistency. CONCLUSIONS: CM criteria had good consistency with CM criteria in evaluating curative effect for Chinese medical treatment of advanced NSCLC. Its results could objectively reflect features and advantages of CM for treating advanced NSCLC.
Subject(s)
Carcinoma, Non-Small-Cell Lung/immunology , Drugs, Chinese Herbal/therapeutic use , Lung Neoplasms/immunology , Medicine, Chinese Traditional/standards , Asian People , Carcinoma, Non-Small-Cell Lung/drug therapy , Humans , Lung Neoplasms/drug therapy , Treatment OutcomeABSTRACT
Isobolographic analysis was used to assess the antioxidant interactions (synergism, addition, and antagonism) of 4 common vegetables (tomato [T], carrot [C], eggplant [E], and purple potato [P]). The lipophilic (L) extracts of T and C (main carotenoids), the hydrophilic (H) extracts of E and P (main phenolics) were mixed by the certain ratios (1:9, 3:7, 1:1, 7:3, 9:1, w/w) and their antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) radical scavenging assays, respectively. Most of the binary mixtures (LC-HE, LC-HP, HE-HP, LT-HE, and LT-HP combinations) showed the synergistic antioxidant effects. In DPPH assay, the greatest antioxidant activity of vegetable combinations was 1:9 LT-HP (EC50 : 2.45 ± 0.13 mg/mL), followed by 9:1 HE-HP (EC50 : 3.62 ± 0.12 mg/mL) and 1:9 LC-HE (EC50 : 3.74 ± 0.47 mg/mL). In ABTS assay, the greatest antioxidant activity of vegetable combinations was 9:1 HE-HP (EC50 : 4.20 ± 0.10 mg/mL), followed by 7:3 HE-HP (EC50 : 4.41 ± 0.63 mg/mL) and 1:1 HE-HP (EC50 : 5.35 ± 0.85 mg/mL). Among these combinations, 1:1 LC-HE combination showed the highest synergistic antioxidant effects in DPPH assay (synergistic rate: 87.4%), and 7:3 LC-HE combination showed the highest synergistic antioxidant effects in ABTS assay (synergistic rate: 87.0%). The mixtures of phenolics and carotenoids with suitable ratios in vegetables effectively enhanced the synergistic antioxidant effects.
Subject(s)
Antioxidants/pharmacology , Carotenoids/pharmacology , Daucus carota/chemistry , Phenols/pharmacology , Plant Extracts/pharmacology , Solanaceae/chemistry , Vegetables/chemistry , Antioxidants/analysis , Benzothiazoles/metabolism , Biphenyl Compounds/metabolism , Carotenoids/analysis , Humans , Solanum lycopersicum/chemistry , Oxidation-Reduction , Phenols/analysis , Picrates/metabolism , Plant Extracts/chemistry , Solanum melongena/chemistry , Solanum tuberosum/chemistry , Sulfonic Acids/metabolismABSTRACT
In order to explore the objective rule and the key factors in the development of diseases, the process from quantitative change to qualitative change, and from health through sub-health to disease, a new thinking of research, enitled by "Constitution-Subhealth-Disease Relation Developing Axis" is offered by the author. This axis took the CM theory on body constitution as a core, with the coordinates composed of physiological and pathological indices concerning the quantitative changes of illness accumulated under sub-health state. Meanwhile, the key factors for advancing the access and inducing qualitative change of illness were denoted. The orientation of the research is starting from two aspects, horizontally on the crowd possessing the same body constitution, and longitudinally on the same person in different conditions. The research sum-up the general rule of disease occurrence through individually studying the process in persons with different body constitutions, then the commonness of diseases developed from the bottom was explored by applying the outcomes of the foregoing global study on the sorted researches of different constitutions.
