Ag/ZnO microcavities with high sensitivity and self-cleaning properties for fast repetitive SERS detection.

A SERS substrate with high sensitivity and reusability was proposed. The chip consists of multiple ZnO microcavities loaded with silver particles. Based on structural characteristics, this coupling between cavity modes and localized surface plasmon modes can highly localize the electric field, where experimental results revealed a detection limit of 10-11 M for R6G. In addition, during carrier control in semiconductors with localized electromagnetic fields, our substrate also exhibits high self-cleaning efficiency and in situ detection stability. Even in a dry environment, it exhibits excellent light-mediated cleaning ability across multiple reuse test cycles. The convenient, rinse-free substrate, with its cost-effective and sustainable features, shows great promise for the study on detection and degradation of active materials.

Microneedle fractional radiofrequency associated with drug delivery for facial atrophic acne scars and skin rejuvenation.

Microneedle fractional radiofrequency (MFRF) has been used to improve photoaging and scars. This study aimed to evaluate the efficacy and safety of MFRF with basic fibroblast growth factor (bFGF) for facial atrophic acne scars and skin rejuvenation by blinded visual evaluation, self-report, and reflective confocal microscopy (RCM). Fifteen subjects were randomized to the MFRF with bFGF group and fifteen to the MFRF group. All subjects underwent three-session therapy and a follow-up period. Significant group differences were in ECCA, global improvement score, satisfaction, and downtime before and after treatment. Combination therapy could be more effective than monotherapy for acne scars and facial rejuvenation. In addition, RCM can be used to observe the changes in skin collagen before and after treatment in evaluating cosmetic efficacy.

Short-term outcomes of perioperative glucocorticoid administration in patients undergoing liver surgery: a systematic review and meta-analysis of randomised controlled trials.

OBJECTIVE: The purpose of this systematic review and meta-analysis was to investigate whether glucocorticoid might be beneficial after hepatectomy. DESIGN: Systematic review and meta-analysis. DATA SOURCES: PubMed, Embase, Cochrane Library and Web of Science. ELIGIBILITY CRITERIA: We included studies assessing the efficacy of perioperative glucocorticoid administration in patients undergoing liver surgery. DATA EXTRACTION AND SYNTHESIS: Four data bases were retrieved for all randomised controlled trials. We considered postoperative complications, hospital stay and postoperative chemistry evaluations as outcomes. Pooled effects of dichotomic variables were expressed as relative risk (RR) with a 95% CI. The mean difference was used for continuous variables and an inverse variance statistical method was adopted. RESULTS: Fourteen studies with 1205 patients were included. Lower risk of overall complications was associated with glucocorticoid (RR, 0.77; 95% CI 0.64 to 0.92), while no difference was found in hospital stay (RR, 0.02; 95% CI -0.47 to 0.51). There were also improvements in postoperative chemistry evaluations including interleukin 6 on day 1 and 3, C reactive protein on day 1, 2 and 3, international normalised ratio on day 2, total bilirubin on day 1, 2, 3 and 5, albumin on day 1. CONCLUSION: Current evidence indicated that perioperative glucocorticoid administration for patients undergoing hepatectomy reduced the risk of overall complications with inhibited postoperative inflammatory response and improved postoperative liver function. PROSPERO REGISTRATION NUMBER: CRD42022307533.

Atomic layer deposition assisted non-destructive strategy for cleaning Ag dendrites based SERS substrates.

Ag dendrites have recently been widely reported due to their excellent surface-enhanced Raman scattering (SERS) properties. However, prepared pristine Ag dendrites are usually contaminated by organic impurities, which has a huge negative impact on their Raman detection and greatly limits their practical applications. In this paper, we reported a facile strategy to obtain clean Ag dendrites by high temperature decomposition of organic impurities. With the assistance of ultra-thin coating via atomic layer deposition (ALD), the nanostructure of Ag dendrites can be retained at high temperature. SERS activity can be recovered after etching ALD coating. Chemical composition tests indicate that the organic impurities can be effectively removed. As a result, the clean Ag dendrites can obtain more clearly discernible Raman peaks and lower limits of detection than the pristine Ag dendrites. Furthermore, it was demonstrated that this strategy is also applicable to clean other substrates, such as gold nanoparticles. Therefore, high temperature annealing with the help of ALD sacrifice coating is a promising and non-destructive strategy to clean the SERS substrates.

Atomic layer deposition assisted fabrication of large-scale metal nanogaps for surface enhanced Raman scattering.

Metal nanogaps can confine electromagnetic field into extremely small volumes, exhibiting strong surface plasmon resonance effect. Therefore, metal nanogaps show great prospects in enhancing light-matter interaction. However, it is still challenging to fabricate large-scale (centimeter scale) nanogaps with precise control of gap size at nanoscale, limiting the practical applications of metal nanogaps. In this work, we proposed a facile and economic strategy to fabricate large-scale sub-10 nm Ag nanogaps by the combination of atomic layer deposition (ALD) and mechanical rolling. The plasmonic nanogaps can be formed in the compacted Ag film by the sacrificial Al2O3deposited via ALD. The size of nanogaps are determined by the twice thickness of Al2O3with nanometric control. Raman results show that SERS activity depends closely on the nanogap size, and 4 nm Ag nanogaps exhibit the best SERS activity. By combining with other porous metal substrates, various sub-10 nm metal nanogaps can be fabricated over large scale. Therefore, this strategy will have significant implications for the preparation of nanogaps and enhanced spectroscopy.

Adjuvant chemoradiotherapy in resected gallbladder cancer: A SEER-based study.

Background: The prognosis of gallbladder cancer (GBC) is dismal. This study aimed to compare the outcomes of adjuvant chemoradiotherapy (ACR) with those of surgery alone (S) and adjuvant chemotherapy (AC). Method: The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify patients diagnosed with GBC and undergoing surgery between 2004 and 2015. The patients were divided into the S, AC, and ACR groups according to their treatment. Categorical variables were compared by Pearson's chi-square test, and a 1:1:1 propensity score matching analysis (PSM) was performed. Overall survival was assessed by Kaplan-Meier curves with log-rank tests. Subgroup analyses were conducted. Result: A total of 5451 patients were identified in the SEER database. After PSM, the two-year survival among patients who received S, AC, and ACR was 36%, 39%, and 45%, respectively. ACR was associated with improved two-year survival (p < 0.001), while the survival rates were similar in the AC and S groups (p = 0.127) but better in the ACR group than in the AC group (p = 0.012). Subgroup analyses indicated that while the two-year survival rates did not differ significantly in stage II GBC patients between the groups (all p > 0.05), ACR was associated with significantly improved two-year survival in stage Ⅲa (p = 0.008), Ⅲb (p < 0.001), and Ⅳb (p < 0.001) GBC patients. Conclusion: The combination of surgery and ACR as the treatment modality provided greater survival benefits for GBC patients, particularly for those with advanced tumor staging.

Non-Hermitian kagome photonic crystal with a totally topological spatial mode selection.

Recently, the study of non-Hermitian topological edge and corner states in sonic crystals (SCs) and photonic crystals (PCs) has drawn much attention. In this paper, we propose a Wannier-type higher-order topological insulator (HOTI) model based on the kagome PC containing dimer units and study its non-Hermitian topological corner states. When balanced gain and loss are introduced into the dimer units with a proper parity-time symmetric setting, the system will show asymmetric Wannier bands and can support two Hermitian corner states and two pairs of complex-conjugate or pseudo complex-conjugate non-Hermitian corner states. These topological corner states are solely confined at three corners of the triangular supercell constructed by the trivial and non-trivial kagome PCs, corresponding to a topological spatial mode selection effect. As compared to the non-Hermitian quadrupole-type HOTIs, the non-Hermitian Wannier-type HOTIs can realize totally topological spatial mode selection by using much lower coefficients of gain and loss. Our results pave the way for the development of novel non-Hermitian photonic topological devices based on Wannier-type HOTIs.

The epidemiological trends of biliary tract cancers in the United States of America.

BACKGROUND: Biliary tract cancers (BTCs) are a series of heterogeneous malignancies that are broadly grouped based on the anatomical site where they arise into subtypes including intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), gallbladder cancer (GBC), and ampulla of Vater cancer (AVC). METHODS AND RESULTS: The present study provides an overview of the epidemiology of the various BTCs based on data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2018. Distinct differences in both incidence and mortality rates were observed for these BTCs as a function of age, sex, ethnicity, and calendar year. In 2018, BTCs emerged as the fifth most prevalent form of alimentary tract cancer in the USA. While the incidence and mortality of ICC appear to be increasing, the incidence rates of GBC, ECC, and AVC have remained stable, as have the corresponding mortality rates. The most common and deadliest BTCs in 2018 were ICC and GBC among males and females, respectively. The ethnic groups exhibiting the highest incidence rates of these different BTCs were American Indians and Alaska Natives for GBC, and Asian and Pacific Islanders for ICC, ECC, and AVC. The incidence of all of these forms of BTC rose with age. There were some variations in BTCs in terms of staging, locoregional surgical treatments, adjuvant therapies, and prognostic outcomes from 2000 to 2018. CONCLUSIONS: The epidemiological characteristics, staging, locoregional surgical treatments, adjuvant therapies, and prognostic outcomes were distinct for each of these BTCs.

Effect of lymph node resection on prognosis of resectable intrahepatic cholangiocarcinoma: A systematic review and meta-analysis.

Background: The purpose of this meta-analysis was to evaluate the efficacy of lymph node dissection in patients with intrahepatic cholangiocarcinoma (ICC). Methods: The literature from January 2009 to December 2021 was searched to determine the comparative study of lymph node dissection and non-lymph node dissection in patients with ICC. Results: Seventeen studies were included in the analysis. There were no significant differences in 1-, 3-, and 5-year overall survival (OR = 0.80, p = 0.10; OR = 0.93, p = 0.71; OR = 0.80, p = 0.21) and 1-, 3-, and 5-year disease-free survival (OR = 0.89, p = 0.73; OR = 0.92, p = 0.81; OR = 0.85, p = 0.62). Conclusions: Lymph node dissection does not seem to have a positive effect on the overall survival and disease-free survival.

Multifunctional and wavelength division multiplexing all-optical logic gates based on four-port metal-insulator-metal waveguides coupled with a ring resonator.

In the past few years, designing multifunctional all-optical logic devices has attracted more and more attention in integrated optical computing. We report a metal-insulator-metal based four-port all-optical logic gate device containing two parallel straight waveguides and a ring resonator. We employ the scattering matrix method to analyze the coupling mechanisms of the hybrid waveguide and adopt the finite-difference time-domain method to design four fundamental logic functions of AND, OR, XOR, and NOT based on the all-optical coherent control of the four-port system under three symmetrically incident conditions. We demonstrate that these logic functions can be freely modulated by changing the phase difference of the input light at two resonant wavelengths or in a broad band. The logic gate device proposed shows a simple structure with multiple functions, multiple channels, and convenience in fabrication, and can be applied in parallel optical computing based on wavelength division multiplexing technology.

Dual-insensitive zero refraction based on annular photonic crystals.

Over the past few years, zero refraction (ZR) represents an important breakthrough in field of distinctive dynamic optical beam tuning for double-zero-index (media with zero relative permittivity and permeability) photonic crystals (PCs). Because accidental ZR effects for conventional PCs is sensitive to the structural or refractive index parameters, how to enhance the robustness of ZR design is vital for applications. Here, we report a pioneering wave property that reveals a non-accidental Dirac-like cone dispersion composed of low- or high-energy bands, corresponding to dual-insensitive ZR effects for both transverse magnetic and transverse electric polarizations based on the same annular PCs. The performance of non-accidental ZR is simultaneously based on refractive index-insensitivity and structural- insensitivity, attributed to a satisfactory filling ratio.

Terahertz nonreciprocal and functionality-switchable devices based on dielectric multilayers integrated with graphene and VO2.

Recently, terahertz (THz) nonreciprocal and functionality-switchable devices have drawn much attention. Here we report a magnetic-free THz unidirectional perfect absorber as well as a functionality-switchable device between the band-pass filter and perfect absorber based on dielectric-graphene multilayers containing a VO2 defect layer. We provide a theoretical explanation for the nonreciprocal transmission properties. The working frequencies of these devices can be tailored by using graphene layers of different chemical potentials.

Sirolimus or Everolimus Improves Survival After Liver Transplantation for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

The effects of mammalian target of rapamycin (mTOR) inhibitors (sirolimus [SRL] and everolimus [EVL]) on survival in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) remain the subject of intense research. Therefore, we performed this systematic review and meta-analysis to investigate the potential survival benefits of mTOR inhibitors (mTORis). Embase, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for all randomized controlled trials (RCTs) and cohort studies investigating effects of SRL or EVL on LT recipients for HCC. The primary outcomes were 1-, 2-, 3-, and 5-year overall survival (OS), and the secondary outcomes were 1-, 2-, and 3-year recurrence-free survival (RFS) and adverse effects. Pooled relative risks (RRs) with 95% confidence interval (CI) were calculated by a fixed or random effects model with Mantel-Haenszel weighting. Subgroup analyses were performed according to crucial clinical characteristics. We also conducted sensitivity analyses to assess the reliability of our findings. A total of 17 studies were included. OS was improved in both RCTs (1 year: RR, 1.04; 95% CI, 1.00-1.08; 2 years: RR, 1.09; 95% CI, 1.02-1.16; 3 years: RR, 1.13; 95% CI, 1.04-1.24; 5 years: RR, 1.13; 95% CI, 1.02-1.26) and cohort studies (1 year: RR, 1.13; 95% CI, 1.06-1.20; 2 years: RR, 1.24; 95% CI, 1.16-1.32; 3 years: RR, 1.24; 95% CI, 1.15-1.34; 5 years: RR, 1.17; 95% CI, 1.10-1.24), with a lower risk of renal toxicity (RR, 0.75; 95% CI, 0.60 to 0.93). The 1-, 2-, and 3-year RFS were also improved. Current evidence indicates that SRL- or EVL-based immunosuppression improves OS and RFS with a lower risk of renal toxicity compared with mTORi-free immunosuppression. Nevertheless, results must be interpreted with caution.

Pulmonary rehabilitation training for improving pulmonary function and exercise tolerance in patients with stable chronic obstructive pulmonary disease.

OBJECTIVE: To investigate the effect of pulmonary rehabilitation training on pulmonary function and exercise tolerance in patients with stable chronic obstructive pulmonary disease (COPD). METHODS: By a random number table method, 90 patients with COPD admitted to our hospital from January 2019 to January 2020 were divided into three groups: the control group (conventional treatment), the observation group A (conventional treatment + pulmonary rehabilitation training three times a week) and the observation group B (conventional treatment + pulmonary rehabilitation training five times a week), with 30 patients in each group. The pulmonary function, exercise tolerance (the 6-min walking distance (6MWD)), sleep quality (Pittsburgh Sleep Quality Index (PSQI)) and quality of life (generic quality of life inventory-74 (GQOLI-74)) before and after intervention were compared among the three groups. Also, the satisfaction rate was recorded in all groups. RESULTS: After 6 months of intervention, the FEV1%, FVC% and FEV1/FVC as well as the GQOLI-74 scores increased significantly, while the PSQI scores decreased markedly in all groups as compared to those before intervention; the index levels and GQOLI-74 scores were significantly higher, and PSQI scores were markedly lower in the observation group B than in the other two groups (all P<0.05). After 3 and 6 months of intervention, the 6MWDs of the three groups were significantly increased compared with those before intervention, and the 6MWD was significantly longer in the observation group B than in the other two groups (P<0.05). Moreover, the satisfaction rate was significantly higher in observation group B than in the other two groups (P<0.05). CONCLUSION: For patients with stable COPD, pulmonary rehabilitation training based on drug therapy can improve the pulmonary function, exercise tolerance, sleep quality and quality of life more effectively than drug treatment alone. What's more, the therapeutic effect of training five times a week is significantly better than that of training three times a week.

Tunable and multifunctional terahertz devices based on one-dimensional anisotropic photonic crystals containing graphene and phase-change material.

In the past few years, designing tunable and multifunctional terahertz devices has become a hot research area in terahertz science and technology. In this work, we report a study on one-dimensional anisotropic photonic crystals (1D APCs) containing graphene and phase-change material VO2. We numerically demonstrate the band-pass filtering, perfect absorption, comb-shaped extraordinary optical transmission and Fano-like resonance phenomenon in pure 1D APCs and 1D APCs with a VO2 defect layer under different conditions of a tangential wave vector. The performance of these phenomena in the terahertz region can be modulated by changing the chemical potential of graphene. The band-pass filter and perfect absorber functions of 1D APCs with a VO2 defect layer can be freely switched by changing the phase of VO2. We employ the equivalent-permittivity model and dispersion-relation equation to give reasonable explanations on these behaviors.

COPB2: A Novel Prognostic Biomarker That Affects Progression of HCC.

PURPOSE: This study is aimed at investigating the expression, underlying biological function, and clinical significance of coatomer protein complex subunit beta 2 (COPB2) in hepatocellular carcinoma (HCC). METHODS: HCC-related data were extracted from The Cancer Genome Atlas (TCGA) database, International Cancer Genome Consortium (ICGC) database, and Gene Expression Omnibus (GEO) database. A logistic regression module was applied to analyze the relationship between the expression of COPB2 and clinicopathologic characteristics. The Cox proportional hazard regression model and Kaplan-Meier method were used for survival analysis. Gene set enrichment analysis (GSEA) was used to annotate the underlying biological functions. Loss-of-function experiments were conducted to determine the underlying mechanisms. RESULTS: COPB2 was overexpressed in HCC, and high expression of COPB2 was significantly correlated with higher alpha fetoprotein (AFP) (odds ratio (OR) = 1.616, >20 vs. ≤20, p < 0.05), stage (OR = 1.744, III vs. I, p < 0.05), and grade (OR = 1.746, G4+G3 vs. G2+G1, p < 0.05). Kaplan-Meier survival analysis showed that HCC patients with high COPB2 expression had a worse prognosis than those with low COPB2 expression (p < 0.0001 for TCGA cohort, p < 0.05 for ICGC cohort). The univariate Cox (hazard ratio (HR) = 1.068, p < 0.0001) and multivariate Cox (HR = 2.011, p < 0.05) regression analyses suggested that COPB2 was an independent risk factor. GSEA showed that mTOR and other tumor-related signaling pathways were differentially enriched in the high COPB2 expression phenotype. Silencing of COPB2 inhibited the proliferation, migration, and invasion abilities by suppressing epithelial-mesenchymal transition and mTOR signaling. CONCLUSION: COPB2 is a novel prognostic biomarker and a promising therapeutic target for HCC.

Multifunctional and multichannel all-optical logic gates based on the in-plane coherent control of localized surface plasmons.

In this Letter, we report a scheme to design multifunctional and multichannel all-optical logic gates based on the in-plane coherent control of localized surface plasmons in an Au nanorod (NR) array on the Si substrate. By using theoretical analysis and structural optimization, we numerically demonstrate a four-channel all-optical logic gate device that can switch three basic logic operations on each NR only by controlling the phase differences of incident beams. This device is ultra-compact in size and shows high extensibility for parallel logic operations, which may be applied in future high-speed on-chip integrated optical computing.

Multifunctional beam steering via switchable negative refraction, self-collimation, and zero refraction effects in conventional and annular photonic crystals.

Negative refraction (NR), self-collimation (SC), and zero refraction (ZR) effects of photonic crystals play an important role in beam steering. In this work, we report a multifunctional beam steering concept in photonic crystals, i.e., integrating two or three of the NR, SC, and ZR effects together at the same frequency. We find the square-lattice dielectric ring photonic crystal is an ideal candidate to realize the switchable function of ZR-SC while the square-lattice dielectric ring photonic crystal is more suitable for realizing the ZR-SC, ZR-NR, and ZR-SC-NR functions. The photonic band theory and an equivalent waveguide model are employed to explain these switchable functions in conventional and annular photonic crystals.

Selectively enhanced Raman/fluorescence spectra in photonic-plasmonic hybrid structures.

The manipulation of the interaction between molecules and photonic-plasmonic hybrid structures is critical for the application of surface-enhanced spectroscopy (SES). Herein, we report a study on the mode coupling mechanism and SES performance in a typical optoplasmonic system constructed with a polystyrene microsphere (PS MS) resonator and gold nanoparticles (Au NPs). The mode coupling mechanism was found to be closely dependent on the relative positions of PS MS, Au NPs, and molecules in the optoplasmonic system, based on which selectively enhanced Raman and fluorescence signals of molecules can be realized via the collaboration of enhancement and quenching channels of the PS MS and Au NPs. We demonstrate two arrangements of the photonic-plasmonic hybrid structure, which can support fluorescence signals with sharp whispering-gallery modes and apparently enhanced Raman signals with relatively low detection limits and good robustness, respectively.

In-plane coherent control of plasmon resonances for plasmonic switching and encoding.

Considerable attention has been paid recently to coherent control of plasmon resonances in metadevices for potential applications in all-optical light-with-light signal modulation and image processing. Previous reports based on out-of-plane coherent control of plasmon resonances were established by modulating the position of a metadevice in standing waves. Here we show that destructive and constructive absorption can be realized in metallic nano-antennas through in-plane coherent control of plasmon resonances, which is determined by the distribution rule of electrical-field components of nano-antennas. We provide proof-of-principle demonstrations of plasmonic switching effects in a gold nanodisk monomer and dimer, and propose a plasmonic encoding strategy in a gold nanodisk chain. In-plane coherent control of plasmon resonances may open a new avenue toward promising applications in optical spectral enhancement, imaging, nanolasing, and optical communication in nanocircuits.