Mediating Effect of Self-Efficacy on the Relationship Between Perceived Social Support and Resilience in Patients with Recurrent Schizophrenia in China.

Purpose: To explore the mediating effect of self-efficacy on the relationship between perceived social support and resilience in patients with recurrent schizophrenia in China. Patients and Methods: In this cross-sectional study, a total of 176 patients with recurrent schizophrenia who were hospitalized in a tertiary hospital in Hunan Province, China, completed a general data questionnaire, the Connor Davidson Resilience Scale (CD-RISC), the Perceived Social Support Scale (PSSS) and the General Self-Efficacy Energy Scale (GSES). Results: Among the 176 patients, the mean GSES score was 2.02±0.61, the mean PSSS score was 56.77±14.61, and the mean CD-RISC score was 58.06±17.26. Self-efficacy played a partial mediating role between social support and resilience, and the mediating effect accounted for 42.56% of the total effect. Conclusion: The resilience level of patients with recurrent schizophrenia in China is moderate and needs to be improved. This research revealed that self-efficacy played a part in mediating perceived social support and resilience in patients with recurrent schizophrenia in China. Perceived social support can indirectly affect resilience in patients with recurrent schizophrenia through self-efficacy. Comprehensive interventions in perceived social support and self-efficacy would help to improve the resilience of patients with recurrent schizophrenia.

S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury.

Pericytes have long been regarded merely to maintain structural and functional integrity of blood-brain barrier (BBB). Nevertheless, it has also been identified as a component of scar-forming stromal cells after spinal cord injury (SCI). In process of enlargement of spinal cavity after SCI, the number of pericytes increased and outnumbered astrocytes. However, the mechanism of proliferation of pericytes remains unclear. Sphingosine-1-phosphate (S1P) has been reported to play important roles in the formation of glia scar, but previous studies had paid more attention to the astrocytes. The present study aimed to observe the effects of S1P and S1P receptors (S1PRs) on proliferation of pericytes and investigate the underlying mechanism. By double immunostaining, we found that the number of PDGFRß-positive pericytes was gradually increased and sealed the cavity, which surrounded by reactive astrocytes. Moreover, the subtype of S1PR3 was found to be induced by SCI and mainly expressed on pericytes. Further, by use of CAY10444, an inhibitor of S1PR3, we showed that S1P/S1PR3 mediated the proliferation of pericytes through Ras/pERK pathway. Moreover, CAY10444 was found to have the effects of enhancing neuronal survival, alleviating glial scar formation, and improving locomotion recovery after SCI. The results suggested that S1P/S1PR3 might be a promising target for clinical therapy for SCI.

[Comparison of spatial interpolation methods for daily meteorological elements].

A comparative study was made to evaluate the methods of inverse distance weighting (IDW), co-kriging (CK), and thin plate spline (TPS) in interpolating the average meteorological elements (including maximum air temperature, minimum air temperature, sunshine hours, and precipitation) of the 15th day per month from the 1951-2005 comprehensive observation data of 559 meteorological stations in China. The results showed that the RMSEs for the maximum and minimum air temperature in a year interpolated by TPS were the smallest (1.02 degrees C and 1.12 degrees C, respectively), and the R2 between the observed and predicted values were the highest (0.9916 and 0.9913, respectively), compared with those interpolated by IDW and CK. In four seasons, the smallest RMSEs for the maximum and minimum air temperature interpolated by TPS were observed in autumn (0.83 degrees C) and summer (0.86 degrees C), respectively, and the R2 between the observed and predicted values interpolated by TPS were higher in autumn than in other seasons. The RMSEs for the sunshine hours and precipitation in a year interpolated by TPS were the smallest (0.59 h and 1.01 mm, respectively), and the R2 between the observed and predicted values were the highest (0.9118 and 0.8135, respectively), compared with those interpolated by IDW and CK. In four seasons, the RMSE for the sunshine hours in winter interpolated by TPS was the smallest (0.49 h), and the R2 between the observed and predicted sunshine hours was the smallest (0.9293). The RMSE for the precipitation in winter interpolated by TPS was the smallest (0.33 mm), while the RMSE for the precipitation in summer interpolated by IDW was the smallest (2.01 mm). The R2 between the observed and predicted precipitation in winter interpolated by CK was the highest (0.8781). It was suggested that TPS could be the optimal spatial interpolation method in interpolating and rasterizing the daily meteorological elements in China.