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1.
PLoS One ; 15(9): e0238760, 2020.
Article in English | MEDLINE | ID: mdl-32886711

ABSTRACT

In this study, we ascertained the chest CT data of 60 patients admitted to 3 hospitals in Chongqing with confirmed COVID-19. We conducted anatomical and pathological analyses to elucidate the possible reasons for the distribution, morphology, and characteristics of COVID-19 in chest CT. We also shared a semiquantitative scoring of affected lung segments, which was recommended by our local medical association. This scoring system was applied to quantify the severity of the disease. The most frequent imaging findings of COVID-19 were subpleural ground glass opacities and consolidation; there was a significant difference in semiquantitative scores between the early, progressive, and severe stages of the disease. We conclude that the chest CT findings of COVID-19 showed certain characteristics because of the anatomical features of the human body and pathological changes caused by the virus. Therefore, chest CT is a valuable tool for facilitating the diagnosis of COVID-19 and semiquantitative scoring of affected lung segments may further elucidate diagnosis and assessment of disease severity. This will assist healthcare workers in diagnosing COVID-19 and assessing disease severity, facilitate the selection of appropriate treatment options, which is important for reducing the spread of the virus, saving lives, and controlling the pandemic.


Subject(s)
Coronavirus Infections/diagnostic imaging , Lung/diagnostic imaging , Pneumonia, Viral/diagnostic imaging , Tomography, Spiral Computed/standards , Adolescent , Adult , Aged , COVID-19 , Child , Coronavirus Infections/pathology , Female , Humans , Lung/pathology , Male , Middle Aged , Pandemics , Pneumonia, Viral/pathology , Severity of Illness Index , Tomography, Spiral Computed/methods
2.
Sci Rep ; 10(1): 5019, 2020 03 19.
Article in English | MEDLINE | ID: mdl-32193472

ABSTRACT

Percutaneous puncture ethanol sclerotherapy is a simple, effective, minimally invasive, and inexpensive procedure to manage symptomatic simple renal cysts. We modified specific technical aspects to balance certain potential intraprocedural factors for ensuring minimal procedural pain and duration as well as maximal clinical therapeutic effects and evaluated the safety and efficacy of this modified technique. A total of 84 eligible patients underwent computed tomography-guided single-session ethanol sclerotherapy using the conventional (group A) or modified (group B) technique. In group B, the puncture route was modified from tansparenchymal to direct for reducing renal injury, and preinjection of low-dose intracystic lidocaine was used to control distending pain caused by ethanol injections; therefore, greater ethanol volumes could be injected for improving the resistance and contact of ethanol with the cyst wall, precluding the need for patient repositioning multiple times to decrease procedural duration. Visual analog scale score for pain and procedural time were significantly higher in group A than in group B. The complication rate was slightly higher in group A than in group B, but the success rate was comparable between the two groups. These results suggest that the modified technique is painless, time-saving, and injury-reducing and can thus improve medical care.


Subject(s)
Ethanol/administration & dosage , Kidney Diseases, Cystic/therapy , Sclerotherapy/methods , Aged , Female , Humans , Injections, Intralesional/methods , Kidney Diseases, Cystic/diagnostic imaging , Male , Middle Aged , Quality Improvement , Quality of Health Care , Sclerotherapy/adverse effects , Tomography, X-Ray Computed , Treatment Outcome
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