ECGVEDNET: A Variational Encoder-Decoder Network for ECG Delineation in Morphology Variant ECGs.

Electrocardiogram (ECG) delineation to identify the fiducial points of ECG segments, plays an important role in cardiovascular diagnosis and care. Whilst deep delineation frameworks have been deployed within the literature, several factors still hinder their development: (a) data availability: the capacity of deep learning models to generalise is limited by the amount of available data; (b) morphology variations: ECG complexes vary, even within the same person, which degrades the performance of conventional deep learning models. To address these concerns, we present a large-scale 12-leads ECG dataset, ICDIRS, to train and evaluate a novel deep delineation model-ECGVEDNET. ICDIRS is a large-scale ECG dataset with 156,145 QRS onset annotations and 156,145 T peak annotations. ECGVEDNET is a novel variational encoder-decoder network designed to address morphology variations. In ECGVEDNET, we construct a well-regularized latent space, in which the latent features of ECG follow a regular distribution and present smaller morphology variations than in the raw data space. Finally, a transfer learning framework is proposed to transfer the knowledge learned on ICDIRS to smaller datasets. On ICDIRS, ECGVEDNET achieves accuracy of 86.28%/88.31% within 5/10 ms tolerance for QRS onset and accuracy of 89.94%/91.16% within 5/10 ms tolerance for T peak. On QTDB, the average time errors computed for QRS onset and T peak are -1.86 ± 8.02 ms and -0.50 ± 12.96 ms, respectively, achieving state-of-the-art performances on both large and small-scale datasets. We will release the source code and the pre-trained model on ICDIRS once accepted.

Detecting and Tracking of Multiple Mice Using Part Proposal Networks.

The study of mouse social behaviors has been increasingly undertaken in neuroscience research. However, automated quantification of mouse behaviors from the videos of interacting mice is still a challenging problem, where object tracking plays a key role in locating mice in their living spaces. Artificial markers are often applied for multiple mice tracking, which are intrusive and consequently interfere with the movements of mice in a dynamic environment. In this article, we propose a novel method to continuously track several mice and individual parts without requiring any specific tagging. First, we propose an efficient and robust deep-learning-based mouse part detection scheme to generate part candidates. Subsequently, we propose a novel Bayesian-inference integer linear programming (BILP) model that jointly assigns the part candidates to individual targets with necessary geometric constraints while establishing pair-wise association between the detected parts. There is no publicly available dataset in the research community that provides a quantitative test bed for part detection and tracking of multiple mice, and we here introduce a new challenging Multi-Mice PartsTrack dataset that is made of complex behaviors. Finally, we evaluate our proposed approach against several baselines on our new datasets, where the results show that our method outperforms the other state-of-the-art approaches in terms of accuracy. We also demonstrate the generalization ability of the proposed approach on tracking zebra and locust.

Ensemble-Based Bounding Box Regression for Enhanced Knuckle Localization.

The knuckle creases present on the dorsal side of the human hand can play significant role in identifying the offenders of serious crime, especially when evidence images of more recognizable biometric traits, such as the face, are not available. These knuckle creases, if localized appropriately, can result in improved identification ability. This is attributed to ambient inclusion of the creases and minimal effect of background, which lead to quality and discerning feature extraction. This paper presents an ensemble approach, utilizing multiple object detector frameworks, to localize the knuckle regions in a functionally appropriate way. The approach leverages from the individual capabilities of the popular object detectors and provide a more comprehensive knuckle region localization. The investigations are completed with two large-scale public hand databases which consist of hand-dorsal images with varying backgrounds and finger positioning. In addition to that, effectiveness of the proposed approach is also tested with a novel proprietary unconstrained multi-ethnic hand dorsal dataset to evaluate its generalizability. Several novel performance metrics are tailored to evaluate the efficacy of the proposed knuckle localization approach. These metrics aim to measure the veracity of the detected knuckle regions in terms of their relation with the ground truth. The comparison of the proposed approach with individual object detectors and a state-of-the-art hand keypoint detector clearly establishes the outperforming nature of the proposed approach. The generalization of the proposed approach is also corroborated through the cross-dataset framework.

Multi-View Mouse Social Behaviour Recognition With Deep Graphic Model.

Home-cage social behaviour analysis of mice is an invaluable tool to assess therapeutic efficacy of neurodegenerative diseases. Despite tremendous efforts made within the research community, single-camera video recordings are mainly used for such analysis. Because of the potential to create rich descriptions for mouse social behaviors, the use of multi-view video recordings for rodent observations is increasingly receiving much attention. However, identifying social behaviours from various views is still challenging due to the lack of correspondence across data sources. To address this problem, we here propose a novel multi-view latent-attention and dynamic discriminative model that jointly learns view-specific and view-shared sub-structures, where the former captures unique dynamics of each view whilst the latter encodes the interaction between the views. Furthermore, a novel multi-view latent-attention variational autoencoder model is introduced in learning the acquired features, enabling us to learn discriminative features in each view. Experimental results on the standard CRMI13 and our multi-view Parkinson's Disease Mouse Behaviour (PDMB) datasets demonstrate that our proposed model outperforms the other state of the arts technologies, has lower computational cost than the other graphical models and effectively deals with the imbalanced data problem.

CANet: Context Aware Network for Brain Glioma Segmentation.

Automated segmentation of brain glioma plays an active role in diagnosis decision, progression monitoring and surgery planning. Based on deep neural networks, previous studies have shown promising technologies for brain glioma segmentation. However, these approaches lack powerful strategies to incorporate contextual information of tumor cells and their surrounding, which has been proven as a fundamental cue to deal with local ambiguity. In this work, we propose a novel approach named Context-Aware Network (CANet) for brain glioma segmentation. CANet captures high dimensional and discriminative features with contexts from both the convolutional space and feature interaction graphs. We further propose context guided attentive conditional random fields which can selectively aggregate features. We evaluate our method using publicly accessible brain glioma segmentation datasets BRATS2017, BRATS2018 and BRATS2019. The experimental results show that the proposed algorithm has better or competitive performance against several State-of-The-Art approaches under different segmentation metrics on the training and validation sets.

A Multipopulation-Based Multiobjective Evolutionary Algorithm.

Multipopulation is an effective optimization component often embedded into evolutionary algorithms to solve optimization problems. In this paper, a new multipopulation-based multiobjective genetic algorithm (MOGA) is proposed, which uses a unique cross-subpopulation migration process inspired by biological processes to share information between subpopulations. Then, a Markov model of the proposed multipopulation MOGA is derived, the first of its kind, which provides an exact mathematical model for each possible population occurring simultaneously with multiple objectives. Simulation results of two multiobjective test problems with multiple subpopulations justify the derived Markov model, and show that the proposed multipopulation method can improve the optimization ability of the MOGA. Also, the proposed multipopulation method is applied to other multiobjective evolutionary algorithms (MOEAs) for evaluating its performance against the IEEE Congress on Evolutionary Computation multiobjective benchmarks. The experimental results show that a single-population MOEA can be extended to a multipopulation version, while obtaining better optimization performance.

Context-Aware Mouse Behavior Recognition Using Hidden Markov Models.

Automated recognition of mouse behaviors is crucial in studying psychiatric and neurologic diseases. To achieve this objective, it is very important to analyze the temporal dynamics of mouse behaviors. In particular, the change between mouse neighboring actions is swift in a short period. In this paper, we develop and implement a novel hidden Markov model (HMM) algorithm to describe the temporal characteristics of mouse behaviors. In particular, we here propose a hybrid deep learning architecture, where the first unsupervised layer relies on an advanced spatial-temporal segment Fisher vector encoding both visual and contextual features. Subsequent supervised layers based on our segment aggregate network are trained to estimate the state-dependent observation probabilities of the HMM. The proposed architecture shows the ability to discriminate between visually similar behaviors and results in high recognition rates with the strength of processing imbalanced mouse behavior datasets. Finally, we evaluate our approach using JHuang's and our own datasets, and the results show that our method outperforms other state-of-the-art approaches.