ABSTRACT
Objective Investigate the clinical effect of thyroid tablets combined with superior thyroid therapy in the treatment of hypothyroidism.Methods 90 patients with hypothyroidism were selected and divided into control group and observation group by random digit table,the control group was given Thyroid Tablets treatment,the observation group was treated with thyroid tablets combined with the use of left thyroid hormone tablets.To investigate the clinical efficacy of 1 groups of patients after two years of treatment,the main indicators of changes and adverse reactions,etc.Results After treatment,the total efficiency of the observation group 95.6% compared with the control group 82.2%,the difference was statistically significant (x2=1.995,P0.05).Conclusion The combination of thyroid tablets and superior thyroid in the treatment of hypothyroidism can significantly improve the clinical symptoms of patients,improve clinical efficacy,and the safety is better,has a larger clinical significance.
ABSTRACT
Objective To analyze the cerebral autoregulation capability in patients with chronic insomnia disorder (CID).Methods Sixty CID patients (54 with generalized anxiety disorder) and 40 healthy controls were enrolled in this study.Polysomnography was done in all the participants.Noninvasive continuous cerebral blood flow velocity of bilateral middle artery and arterial blood pressure were recorded simultaneously using transcranial Doppler and a servo-controlled plethysmograph.Transfer function analysis was used to derive the autoregulatory parameters, including phase difference and coherence function.Results The phase difference values of CID patients with generalized anxiety disorder were significantly lower than that of the healthy controls ((46.89±15.39)°vs (56.00±12.05)°, t=3.439, P=0.001).In the correlation analysis, we further found that there was no correlation among phase difference values and the score of Hospital Anxiety and Depression scale.Conclusions The dynamic cerebral autoregulation was compromised in CID patients with generalized anxiety disorder regardless of the degrees of anxiety and depression.Dynamic cerebral autoregulation may be a potential therapeutic target in improving neurological symptoms in patients with CID.
