ABSTRACT
Objective To investigate the treatment for severe hypertensive intracerebral hemorrhage (SHIH). Methods Between May 1997 and December 2003 A total of 110 cases of SHIH were divided into two groups with 55 cases in each group: Conservative Group (Control Group) was treated by medical conservative management, and Minimally Invasive Group was given a combination therapy of minimally invasive puncture and drainage, infusion with urokinase, and intravenous dripping of ?-aescine sodium. Results In the Minimally Invasive Group, the rate of significant improvement, the total effective rate, and the death rate were 81.8% (45/55), 89.1% (49/55), and 10.9% (6/55), respectively. The corresponding values in the Control Group were 32.7% (18/55), 49.1% (27/55), and 43.6% (24/55), respectively. The curative effect in the Minimally Invasive Group was superior to that in the Control Group (?2=20.604, P=0.000). Conclusions[WTBZ] The combination therapy of minimally invasive puncture and drainage, infusion with urokinase, and intravenous administration of ?-aescine sodium in the treatment of severe hypertensive intracerebral hemorrhage is simple, safe, and effective. The treatment has fewer complications and significantly improves the prognosis of patients.