Progress in Precision Medicine of Radiomics in Abdominal Tumors Practice / 中国医疗器械杂志

With the advent of the era of artificial intelligence, as an emerging technology, radiomics can extract a large amount of quantitative information describing the physiological condition and phenotypic characteristics of tumors with high throughput from the massive data of CT, MRI and other imaging tomography, and analyze these high-dimensional imaging omics features containing disease pathophysiological information can be used to accurately determine tumor differentiation, staging, and predict tumor behavior, which has broad application prospects. This article aims to introduce the technical principles of radiomics and its abdominal tumor application status, and to prospect its application prospects in pediatric abdominal neuroblastoma.

One-Step Rapid Quantification of Serum Neutralizing Antibody after COVID-19 Vaccination by a High-Throughput Nanoplasmonic Sensor Platform

The COVID-19 vaccination efficacy depends on serum production level of the neutralizing IgG antibody (NA) specific to the receptor binding domain of SARS-Cov-2 spike protein. Therefore, a high-throughput rapid assay to measure the total SARS-CoV-2 NA level is urgently needed for COVID-19 serodiagnosis, convalescent plasma therapy, vaccine development, and assessment. Here, we developed a nanoplasmonic immunosorbent assay (NanoPISA) platform for one-step rapid quantification of SARS-CoV-2 NAs in clinical serum samples for high-throughput evaluation of COVID-19 vaccine effectiveness. The NanoPISA platform enhanced by the use of nanoporous hollow gold nanoparticle coupling was able to detect SARS-CoV-2 NAs with a limit of detection of 0.1 ng/mL within 15 min. The one-step NanoPISA for SARS-CoV-2 NA detection in clinical specimens yielded good results, comparable to those obtained in the gold standard seroneutralization test and the surrogate virus neutralizing ELISA. Collectively, our findings indicate that the one-step NanoPISA may offer a rapid and high-throughput NA quantification platform for evaluating the effectiveness of COVID-19 vaccines.

X-ray Diagnosis of Primary Malignant Lymphoma of Bone / 实用放射学杂志

Objective To study the X-ray and CT representations of primary malignant lymphoma of bone.Methods X-ray and CT representations of primary malignant lympoma of bone in 27 cases proved by operation and pathology,combined with clinic manifestations,operation and pathology were analysed.Results The tumors located in vertebra were 14 cases(51.9%),in tubular bone were 9 cases(33.3%).The imaging findings included bone destroy in 85.7%,bone sclerosis in 7%;only 4 cases appeared light periosteous reaction;one case appeared multiple focuses.Conclusion When the dissolved bone destruction without periosteous reaction,presented soft tissue mass in vertebras or tubular bone are showed on X-ray films or CT,the possibility of bone lymphoma shonld be considered,but this neoplasm is lack of characteristic imaging features.