Subject(s)
Brain/physiology , Electroencephalography , Pentobarbital/pharmacology , Animals , Brain/growth & development , Male , RatsSubject(s)
Evoked Potentials , Hypoxia/physiopathology , Somatosensory Cortex/physiopathology , Animals , Animals, Newborn , Rats , Time FactorsABSTRACT
PIP: 300 male rats aged 5, 12, 18, and 25 days, and those that were adult, were administered stagnant anoxia by means of a positive radial speed of 10 gm in a centrifuge of the authors' construction. The animals were administered either 50 gamma per animal of estrogen or 50 gamma/10 gm of body weight 24 hours prior to the positive gravitation. The administration of estrogens was found to increase the animals resistance to this form of stagnant anoxia throughout the course of postnatal ontogenesis. No sex-linked differences in the level of this resistance to stagnant anoxia were observed.^ieng
Subject(s)
Estrogens/administration & dosage , Growth , Hypoxia/prevention & control , Animals , Female , Male , RatsABSTRACT
In the rat prosencephalon it proved possible to differentiate lysosomal ribonuclease from alkaline ribonuclease activity, which could be detected only in the presence of p-chlormercuribenzoate. Acid RNase activity related to the amount of protein in the prosencephalon fell during ontogenesis. It was not significantly affected by four hours' stagnant hypoxia induced by ligation of both carotids. Its release from the lysosomes rose, however (when isotonic homogenates were spun at 20,000 g, acid ribonuclease activity in the supernatants was elevated). The absence of correlation between this activation and the degree of maturity of the nervous tissue refutes the hypothesis that regulation of this enzyme is per se responsible for the known changes induced by hypoxia in the RNA content of the prosencephalon of rats of different ages. On the contrary, the results indirectly support studies which demonstrate changes in the extent of RNA synthesis after hypoxia.
Subject(s)
Brain/enzymology , Hypoxia/enzymology , Ribonucleases/metabolism , Age Factors , Animals , Brain/embryology , Female , Proteins/metabolism , RatsSubject(s)
Adaptation, Physiological , Hypoxia/enzymology , Oxidoreductases/metabolism , Transaminases/metabolism , Animals , Female , Male , Rats , Time FactorsSubject(s)
Central Nervous System/enzymology , Growth , Hypoxia/enzymology , L-Lactate Dehydrogenase/metabolism , Succinate Dehydrogenase/metabolism , Adaptation, Physiological , Altitude , Animals , Animals, Newborn , Brain/enzymology , Brain/growth & development , Glutamate Dehydrogenase/metabolism , Histocytochemistry , Rats , Time FactorsSubject(s)
Cerebral Cortex/physiopathology , Electroencephalography , Hypoxia/physiopathology , Animals , RatsABSTRACT
In the present paper the author describes the influence of the psychopharmaceutical preparation Chlorprotixen on the response of the CNS to stagnation anoxia (positive radial acceleration 10 g) and aerogenic hypoxia (15 000 m) in the course of ontogeny of the rat. Chlorprotixen increases the resistance to high altitude hypoxia, while it reduces the resistance to anoxia. The greatest differences were observed in the youngest animals.