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1.
Front Neurol ; 15: 1427273, 2024.
Article in English | MEDLINE | ID: mdl-39206295

ABSTRACT

Introduction: Several studies demonstrate the relationship between preterm birth and a reduced thalamus volume at term-equivalent age. In contrast, this study aims to investigate the link between the thalamic growth trajectory during the early postnatal period and neurodevelopment at two years of age. Methods: Thalamic volume was extracted from 84 early MRI scans at postmenstrual age of 32.33 (± 2.63) weeks and 93 term-equivalent age MRI scans at postmenstrual age of 42.05 (± 3.33) weeks of 116 very preterm infants (56% male) with gestational age at birth of 29.32 (± 2.28) weeks and a birth weight of 1158.92 (± 348.59) grams. Cognitive, motor, and language outcomes at two years of age were assessed with Bayley Scales of Infant and Toddler Development Third Edition. Bivariate analysis was used to describe the clinical variables according to neurodevelopmental outcomes and multilevel linear regression models were used to examine the impact of these variables on thalamic volume and its relationship with neurodevelopmental outcomes. Results: The results suggest an association between severe brain injury and thalamic growth trajectory (ß coef = -0.611; p < 0.001). Moreover, thalamic growth trajectory during early postnatal life was associated with the three subscale scores of the neurodevelopmental assessment (cognitive: ß coef = 6.297; p = 0.004; motor: ß coef = 7.283; p = 0.001; language: ß coeficient = 9.053; p = 0.002). Discussion: These findings highlight (i) the impact of severe brain injury on thalamic growth trajectory during early extrauterine life after preterm birth and (ii) the relationship of thalamic growth trajectory with cognitive, motor, and language outcomes.

2.
Healthcare (Basel) ; 12(13)2024 Jul 03.
Article in English | MEDLINE | ID: mdl-38998865

ABSTRACT

This study examines the association between nurses' perception of caring and attitudes toward caring for dying patients in end-of-life care units. We used a descriptive cross-sectional design with convenience sampling. Data were collected from May to June 2021 through self-reported questionnaires from 303 Spanish nurses (mean age = 48 years, 78.9% female). Participants completed the Caring Dimension Inventory (CDI-25) and the Frommelt Attitudes Toward Care of the Dying scale. Demographic and training information were collected. Data were analyzed using Stata 16.0. Attitudes toward Care of the Dying Patient were significantly higher in nurses with palliative care training (ß = 2.829, p = 0.018) and those who scored higher on the psychosocial (ß = 0.789, p = 0.0001) and technical dimensions (ß = 0.487, p = 0.011) of the CDI-25. Multivariate analysis identified the psychosocial dimension of the CDI-25 scale (ß = 0.783, p = 0.0001) and palliative care training (ß = 2.686, p = 0.017) as the only significant variables associated with Attitudes toward Care of the Dying Patient. Overall, nurses exhibited a positive attitude toward caring for dying patients. Our results could potentially help nursing directors identify those with the necessary qualities and training for optimal end-of-life care and to further plan training courses to provide optimal care in end-of-life situations.

3.
Pediatr Res ; 96(2): 409-417, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38225451

ABSTRACT

BACKGROUND: The corpus callosum (CC) is suggested as an indirect biomarker of white matter volume, which is often affected in preterm birth. However, diagnosing mild white matter injury is challenging. METHODS: We studied 124 children born preterm (mean age: 8.4 ± 1.1 years), using MRI to assess CC measurements and cognitive/motor outcomes based on the Wechsler Intelligence Scale for Children-V (WPPSI-V) and Movement Assessment Battery for Children-2 (MABC-2). RESULTS: Children with normal outcomes exhibited greater height (10.2 ± 2.1 mm vs. 9.4 ± 2.3 mm; p = 0.01) and fractional anisotropy at splenium (895[680-1000] vs 860.5[342-1000]) and total CC length (69.1 ± 4.8 mm vs. 67.3 ± 5.1 mm; p = 0.02) compared to those with adverse outcomes. All measured CC areas were smaller in the adverse outcome group. Models incorporating posterior CC measurements demonstrated the highest specificity (83.3% Sp, AUC: 0.65) for predicting neurological outcomes. CC length and splenium height were the only linear measurements associated with manual dexterity and total MABC-2 score while both the latter and genu were related with Full-Scale Intelligence Quotient. CONCLUSIONS: CC biometry in children born very preterm at school-age is associated with outcomes and exhibits a specific subregion alteration pattern. The posterior CC may serve as an important neurodevelopmental biomarker in very preterm infants. IMPACT: The corpus callosum has the potential to serve as a reliable and easily measurable biomarker of white matter integrity in very preterm children. Estimating diffuse white matter injury in preterm infants using conventional MRI sequences is not always conclusive. The biometry of the posterior part of the corpus callosum is associated with cognitive and certain motor outcomes at school age in children born very preterm. Length and splenium measurements seem to serve as reliable biomarkers for assessing neurological outcomes in this population.


Subject(s)
Biometry , Cognition , Corpus Callosum , Infant, Extremely Premature , Magnetic Resonance Imaging , Humans , Corpus Callosum/diagnostic imaging , Female , Male , Child , Infant, Newborn , White Matter/diagnostic imaging , Infant, Premature , Wechsler Scales , Motor Skills
4.
Eur J Pediatr ; 182(11): 5119-5129, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37682341

ABSTRACT

The purpose of this study is to define the impact of early brain growth trajectory in very low birth weight infants (VLBWI) on neurological prognosis at 2 years, assessed using sequential ultrasound (US) scans. This is a prospective cohort study with consecutive inclusion of VLBWI ≤ 32 weeks gestational age and ≤ 1500 g at birth. Total brain volume (TBV) was assessed using sequential 3D-US from birth to discharge. Prognosis at 2 years (corrected age) was assessed using the Bayley Scales of Infant and Toddler Development Third Edition. TBV showed slower growth with postmenstrual age (PMA) in those VLBWI who had an adverse cognitive prognosis compared to those with good cognitive prognosis (mean difference in TBV between prognostic groups from 4.56 cm3 at 28 weeks to 42.58 cm3 at 43 weeks) as well as in those with adverse language prognosis (mean difference in TBV from 2.21 cm3 at 28 weeks to 26.98 cm3 at 43 weeks) although other variables showed more impact than TBV on language prognosis (gestational age at birth, brain injury at term, and socioeconomic status). No association was found between TBV and motor prognosis. Brain growth rate was also significantly higher in those VLBWI who presented good cognitive scores (18.78 + (0.33 × (PMA-33)) cm3/week) compared to those with adverse cognitive outcome (13.73 + (0.64 × (PMA-33)) cm3/week).  Conclusion: Early altered brain growth is associated with poor cognitive prognosis at 2 years of age. Using sequential US monitoring, we can detect early brain growth deviation in patients who will have adverse cognitive outcomes. What is known: • The prediction of neurodevelopmental outcome of VLBWI is mostly based on the presence of brain injury in US and structural magnetic resonance imaging (MRI) at term. • Some studies have related brain volume measured on MRI at term with neurodevelopment outcome. What is new: • VLBWI with adverse cognitive prognosis at two years of age present smaller brain volumes detectable by sequential US during NICU admission. • Brain volume can be estimated from 2D and 3D US and has prognostic value in VLBWI.


Subject(s)
Brain Injuries , Infant, Premature , Infant, Newborn , Infant , Humans , Prospective Studies , Brain/diagnostic imaging , Infant, Very Low Birth Weight , Gestational Age
5.
Clín. salud ; 32(3): 139-146, nov. 2021. ilus, tab
Article in Spanish | IBECS | ID: ibc-217807

ABSTRACT

Ese trabajo analiza el ajuste psicológico y se comprueba un modelo teórico propuesto que relaciona la presencia de síntomas psicopatológicos con una peor calidad de vida relacionada con la salud (CVRS) de adultos adoptados. Participaron 177 adultos jóvenes adoptados (media 27.67 años). Se tomaron medidas de síntomas psicopatológicos (SCL-90), calidad de vida (SF-12), autoestima (RSES) y resiliencia (BRS). El modelo de mediación múltiple resultante indica que además de la relación directa entre psicopatología y CVRS, la resiliencia y la autoestima tienen un efecto amortiguador en esta relación. Como conclusiones, se evidencia el impacto de las dificultades en salud mental en la CVRS de personas adoptadas. La presencia de recursos psicológicos positivos, como resiliencia y autoestima, hace que dimensiones psicopatológicas como ansiedad, depresión, fobias o psicoticismo pierdan valor. Se sugiere incluir programas que potencien la resiliencia como estrategia para mejorar la salud y en los servicios de postadopción. (AU)


This paper analyses psychological adjustment and checks a suggested theoretical model that relates the presence of psychopathological symptoms to a worse health-related quality of life (HRQOL) in adult adoptees. The sample consisted of 177 young adopted adults (mean age 27.67). Measures of psychopathological symptoms (SCL-90), quality of life (SF-12), self-esteem (RSES), and resilience (BRS) were taken. The multiple mediation model shows that, in addition to the direct association between psychopathological symptomatology and a poorer HRQOL, resilience, and self-esteem have a buffering effect on this relationship. As a conclusion, empirical evidence of the impact of mental health difficulties on the HRQOL of adopted people is shown. The presence of positive psychological resources, such as resilience and self-esteem, causes psychopathological dimensions, such as anxiety, depression, phobias, or psychoticism to decrease. This paper supports the inclusion of resilience-building programs as a health promotion strategy, especially in the case of psychopathology, and among post-adoption services. (AU)


Subject(s)
Humans , Male , Female , Young Adult , Adult , Mental Health , Quality of Life , Adoption/psychology , Interviews as Topic , Surveys and Questionnaires , Psychopathology , Resilience, Psychological , Self Concept
6.
Qual Life Res ; 28(12): 3281-3291, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31388816

ABSTRACT

PURPOSE: The main objective is to study the health-related quality of life (HRQoL) as a positive approach to health in adult adoptees. We will also consider comparison with population norms, relation to chronic medical conditions, the role of sociodemographic variables, and gender differences among the variables in this study. METHODS: This was a cross-sectional study of 179 adult domestic adoptees from Spain aged between 18 and 44. They were recruited from a longitudinal study, which was on its third wave. They answered an interview and the self-report measure Health Survey Short Form (SF-12). ANOVAs and t test analyses to compare groups, and multiple regression to determine predictors of HRQoL, were performed. RESULTS: Adoptees are not different from the general population in terms of perceived physical health (PH) and mental health (MH). Both PH and MH are related to different variables (e.g., current age is negatively associated with PH, as is the number of chronic medical conditions with MH). Despite the absence of gender differences in MH perception, there were common and different predictor variables for males and females. The number of chronic medical conditions predicts HRQoL regardless of gender. For women, employment is also a predictor, and for men, other variables are being in a romantic relationship, having children, and low income. CONCLUSIONS: Adult adoptees are comparable to general population in terms of HRQoL, but there are associated variables (chronic medical conditions and gender) that should be considered. Post-adoption services should promote health and support in life transitions for this group.


Subject(s)
Adoption/psychology , Health Status , Mental Health/statistics & numerical data , Quality of Life/psychology , Adult , Aged , Chronic Disease , Cross-Sectional Studies , Employment , Female , Health Surveys , Humans , Longitudinal Studies , Male , Middle Aged , Multivariate Analysis , Sex Factors , Spain , Young Adult
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