ABSTRACT
Of the head and neck tumoral lesions in children and adolescents, 5%-10% are primary malignant tumors. Among these tumors, orbital rhabdomyosarcoma stands out, which is the most common primary soft tissue sarcoma in children. Its diagnosis requires a high degree of clinical suspicion, and it can be corroborated with a series of examinations, in order to stage it and carry out the appropriate treatment. Currently, surgery and chemotherapy are the primary treatments, and the use of conventional radiotherapy is limited to cases where previous treatments fail or there is a risk of recurrence. The following case report aims to expose the clinical picture, diagnosis, staging and integral treatment of orbital rhabdomyosarcoma, as well as the interdisciplinary management that was performed to improve the patient's prognosis.
Subject(s)
Head and Neck Neoplasms , Rhabdomyosarcoma , Adolescent , Humans , Neoplasm Recurrence, Local , Prognosis , Rhabdomyosarcoma/diagnosisABSTRACT
De las lesiones tumorales de cabeza y cuello en niños y adolescentes, un 5 a un 10% son tumores malignos primarios. Dentro de estos tumores destaca el rabdomiosarcoma orbitario infantil, que es el sarcoma primario de tejido blando más común en niños. Su diagnóstico requiere de un alto grado de sospecha clínica, que puede corroborarse con una serie de exámenes, para así estadificarlo e indicar el tratamiento adecuado. Actualmente se utiliza de primera intención cirugía y quimioterapia; el uso de la radioterapia convencional se limita a casos en los que fracasan los tratamientos anteriores o existe riesgo de recurrencia. El siguiente trabajo tiene como propósito exponer el cuadro clínico, diagnóstico, la estadificación y tratamiento integral de un rabdomiosarcoma embrionario orbitario, así como el manejo interdisciplinario que se realizó para mejorar el pronóstico de la paciente (AU)
Of the head and neck tumoral lesions in children and adolescents, 5 to 10% are primary malignant tumors. Among these tumors, orbital rhabdomyosarcoma stands out, which is the most common primary soft tissue sarcoma in children. Its diagnosis requires a high degree of clinical suspicion, and it can be corroborated with a series of examinations, in order to stage it and carry out the appropriate treatment. Currently, surgery and chemotherapy are the primary treatments, and the use of conventional radiotherapy is limited to cases where previous treatments fail or there is a risk of recurrence. The following case report aims to expose the clinical picture, diagnosis, staging and integral treatment of orbital rhabdomyosarcoma, as well as the interdisciplinary management that was performed to improve the patient's prognosis (AU)
Subject(s)
Humans , Female , Child , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/therapy , Rhabdomyosarcoma/diagnosis , Rhabdomyosarcoma/therapy , Neoplasm Staging , Patient Care Team , Treatment OutcomeABSTRACT
Of the head and neck tumoral lesions in children and adolescents, 5 to 10% are primary malignant tumors. Among these tumors, orbital rhabdomyosarcoma stands out, which is the most common primary soft tissue sarcoma in children. Its diagnosis requires a high degree of clinical suspicion, and it can be corroborated with a series of examinations, in order to stage it and carry out the appropriate treatment. Currently, surgery and chemotherapy are the primary treatments, and the use of conventional radiotherapy is limited to cases where previous treatments fail or there is a risk of recurrence. The following case report aims to expose the clinical picture, diagnosis, staging and integral treatment of orbital rhabdomyosarcoma, as well as the interdisciplinary management that was performed to improve the patient's prognosis.
ABSTRACT
This study describes the effects of short- and long-term ethanol treatment and withdrawal on the biosynthesis of the phospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) in hepatocytes isolated from rats, using isotopically labelled choline and ethanolamine as exogenous precursors. Our results demonstrate that short-term ethanol consumption increases the incorporation of exogenous polar bases into PC and PE, whereas long-term ethanol administration provokes a differential effect in both PC and PE biosynthesis via cytidine diphosphate derivatives (CDP-derivatives), decreasing PC synthesis and increasing the biosynthesis of PE. We suggest that the increased biosynthesis of PE after ethanol treatment results from changes in lipogenic substrates produced as a consequence of ethanol metabolism, whilst the specific inhibition of PC biosynthesis seems to be a consequence of alterations of enzymes involved in the CDP-choline pathway. With regard to the influence of ethanol on PE methylation to give PC, our results demonstrate that ethanol activates this pathway in short-term, as well as chronic ethanol treatment. Ethanol withdrawal returns the activity of the PC and PE pathways to control levels. The alterations in the biosynthesis of the main phospholipids, PC and PE, demonstrated in this study could be of a great physiological interest in determining the pathology of alcoholism.
Subject(s)
Ethanol/pharmacology , Hepatocytes/metabolism , Liver/drug effects , Phosphatidylcholines/biosynthesis , Phosphatidylethanolamines/biosynthesis , Substance Withdrawal Syndrome/metabolism , Animals , Cells, Cultured , Diet , Liver/metabolism , Male , Rats , Rats, Sprague-Dawley , Time FactorsABSTRACT
Presentation of 3 cases of retroperitoneal paraganglioma non pre-operatively diagnosed: one dependent of the Zuckerkandl's organ with ultrasound examination showing a panelled cystic mass, and two located in the renal parahilar area, all accidental findings during renal surgery. Lack of appropriate pre-operative background and diagnosis produced a hypertensive crisis in one patient during removal manoeuvres which was entirely controlled. After a 4-, 2- and 1-year follow-up, respectively, patients remain asymptomatic and disease-free. An analysis of the most relevant features in these retroperitoneal tumorations was carried out from a clinical, diagnostic, therapeutic and prognostic point of view.
Subject(s)
Paraganglioma , Retroperitoneal Neoplasms , Adult , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Paraganglioma/diagnosis , Paraganglioma/therapy , Retroperitoneal Neoplasms/diagnosis , Retroperitoneal Neoplasms/therapyABSTRACT
Herein we describe an additional case of giant ureteral calculus with no evidence of an underlying ureteral lesion that could favour stone formation. The more relevant features of these concretions are discussed.
Subject(s)
Ureteral Calculi/diagnosis , Adult , Humans , MaleABSTRACT
Presentation of a new case of polyorchism, its first clinical evidence being a picture o acute scrotal bag requiring surgical examination. Review of current status with regard to diagnostic and therapeutic procedures.
Subject(s)
Spermatic Cord Torsion/etiology , Testis/abnormalities , Adolescent , Humans , Male , Spermatic Cord Torsion/surgeryABSTRACT
One of the symptoms most frequently encountered in the daily pediatric practice is cough. Most acute pictures are responsible for viral processes. However, chronicity calls for more specific laboratory studies, since the etiology is multifactorial.
Subject(s)
Cough/etiology , Adolescent , Antitussive Agents/therapeutic use , Bronchitis/complications , Child , Child, Preschool , Chronic Disease , Cough/physiopathology , Cough/therapy , Humans , Infant , Physical Therapy Modalities , Pneumonia/complications , Sinusitis/complications , Virus Diseases/complicationsABSTRACT
La presencia de tos en la edad pediatrica, es uno de los problemas mas frecuentes que se presentan en la consulta diaria. Los cuadros agudos son en su mayoria resultados de procesos virales; sin embargo, la cronicidad implica estudios mas especificos, tanto de laboratorio como de gabinete, ya que la etiologia es multifactorial
