Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters











Database
Language
Publication year range
1.
Transplant Proc ; 50(2): 485-492, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29579833

ABSTRACT

BACKGROUND: Hepatocellular carcinoma (HCC) is the most frequent primary malignant liver tumor, with the Milan criteria considered to be the gold standard for patient selection for liver transplantation (LT). MATERIALS AND METHODS: We performed a descriptive observational study, reviewing 20 years of experience of LT in patients with HCC in the Fundacion Valle del Lilí in Cali, Colombia. Subgroup analysis was undertaken for periods 1999 to 2007 and 2008 to 2015. RESULTS: Fifty-seven cases with a pretransplant HCC diagnosis were reviewed. In the first period patients within the Milan criteria had a recurrence-free survival at 5 years of 66.6%, and in those who exceeded the Milan criteria, recurrence-free survival was 75%. In the second period, patients within the Milan criteria, recurrence-free survival at 5 years was 93.5%, and in those who exceeded the Milan criteria, recurrence-free survival was 75.7%. No statistically significant difference was found in either period. For patients with mild and moderate tumor differentiation, the relapse survival rate at 5 years was 69.4% (95% confidence interval [CI] 35.8-87.8) and 74.7% (95% CI 44.5-90), respectively. All patients with poor tumor differentiation relapsed and died within 3 years. CONCLUSION: Global and recurrence-free survival among patients who met and patients who exceeded the Milan criteria was not significantly different, suggesting an expansion of the Milan criteria to include potential recipients who were previously excluded. Obtaining histologic differentiation and identifying vascular invasion will provide a more worthwhile contribution to LT decision making.


Subject(s)
Carcinoma, Hepatocellular/pathology , Carcinoma, Hepatocellular/surgery , Liver Neoplasms/pathology , Liver Neoplasms/surgery , Liver Transplantation/mortality , Adult , Aged , Colombia/epidemiology , Disease-Free Survival , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local/epidemiology , Neoplasm Recurrence, Local/pathology , Patient Selection
2.
Transplant Proc ; 50(2): 493-498, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29579834

ABSTRACT

BACKGROUND: Around 2.4% of the world's population is infected with hepatitis C virus (HCV), and it is the most common cause of liver transplantation (LT) in the world. Latin America (LA), with nearly 9% of the world population, has had a continuous increase in the number of LTs per year. Yet, due to the lack of mandatory data collection and a well-developed health-care system, access to transplantation is limited in most LA countries. We report the first LA experience of HCV-infected LT patients. METHODS: We performed a retrospective cohort study by reviewing the medical histories of all HCV-infected LT patients between 1996 and 2016 who acquired HCV before their LT, at the Fundación Valle del Lilí, Cali, Colombia. RESULTS: Between January 1996 and December 2015, a total of 770 LTs were performed, of which 75 had a cirrhotic liver due to HCV infection. With a median follow-up time of 24.4 months (interquartile range [IQR] 4.7-61.2 months), patient survival was 44.9% and 66.9% for the time periods 1996-2006 and 2007-2015, respectively. Hepatocellular carcinoma (HCC) was present in 30.6% of the patients, and overall postoperative complications had an incidence of 80%. CONCLUSIONS: This is the first report of LT in HCV-infected patients in Colombia and in LA. Our results are comparable to those of other transplant centers worldwide with regard to postoperative complications and patient survival. Patients with LT in the 1996-2006 time frame had higher morbidity and mortality. Studies including larger numbers of patients are needed to determine the reason for this finding.


Subject(s)
Hepatitis C/surgery , Liver Transplantation , Adult , Carcinoma, Hepatocellular/complications , Carcinoma, Hepatocellular/epidemiology , Cohort Studies , Colombia , Female , Hepacivirus , Hepatitis C/complications , Humans , Incidence , Liver Neoplasms/complications , Liver Neoplasms/epidemiology , Liver Transplantation/mortality , Male , Middle Aged , Postoperative Complications , Retrospective Studies
3.
Prev Vet Med ; 101(3-4): 157-62, 2011 Sep 01.
Article in English | MEDLINE | ID: mdl-21737166

ABSTRACT

Campylobacter fetus is a major venereal pathogen of cattle that is considered to be widespread among the livestock population of Argentina. The disease accounts for a 10% reduction in the weaning rate of Argentine infected herds and annual losses of $165 million. A case-control, questionnaire-based study was developed with the objective of quantifying the association between C. fetus infection and demographic, husbandry, and sanitary factors in 196 herds located in the province of Buenos Aires, Argentina. Abortions observed in the herd (OR=3.08, 95% CI=1.52, 6.23), and trespassing of bulls from neighboring herds (OR=2.03, 95% CI=0.98, 4.20), were positively associated with the risk of finding C. fetus-infected bulls, whereas buying bulls was a protective factor for the disease (OR=0.53, 95% CI=0.26, 1.08). Results presented here will help to develop and implement actions aimed at preventing the spread and reducing the incidence of C. fetus infection in the beef cattle population of Argentina.


Subject(s)
Abortion, Veterinary/microbiology , Campylobacter Infections/veterinary , Campylobacter fetus/isolation & purification , Cattle Diseases/microbiology , Pregnancy Complications, Infectious/veterinary , Sexually Transmitted Diseases, Bacterial/veterinary , Abortion, Veterinary/epidemiology , Animal Husbandry/methods , Animals , Antibodies, Bacterial/blood , Argentina/epidemiology , Campylobacter Infections/epidemiology , Campylobacter Infections/microbiology , Campylobacter Infections/transmission , Case-Control Studies , Cattle , Cattle Diseases/epidemiology , Cattle Diseases/transmission , Female , Fluorescent Antibody Technique, Direct/veterinary , Incidence , Logistic Models , Male , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Complications, Infectious/microbiology , Sexually Transmitted Diseases, Bacterial/epidemiology , Sexually Transmitted Diseases, Bacterial/microbiology , Sexually Transmitted Diseases, Bacterial/transmission , Surveys and Questionnaires
4.
J Reconstr Microsurg ; 8(4): 319-23, 1992 Jul.
Article in English | MEDLINE | ID: mdl-1629811

ABSTRACT

The effects of injury on peripheral nerve blood flow were studied, using a Laserflo blood perfusion monitor. A total of 11 nerves were studied, five normal and six injured nerves in four patients. Two of the patients had lacerating brachial plexus injuries, and two other patients had compressive neuropathies of their ulnar nerves at the elbow. All of the readings were taken intraoperatively while the patients were undergoing exploration and repair under general anesthesia. Measurements of the damaged nerves were taken serially from the site of injury proximally and distally, by approximating a flexible metric ruler to the dorsal aspect of the nerve along the same axis. In the acutely lacerated injured nerves (3 to 7 days), the measurements were taken at 1, 5, 10, and 20 mm. The maximal amount of retraction in any of the nerves was 1 cm; thus, the overall architecture of the nerves was maintained. In the compressed nerves, measurements were taken at 1, 2 and 3 cm proximal and distal to the medial epicondyle. Measurement of normal undamaged nerves was performed at six different sites along the same axis of the nerve. The averaged results indicate that the normal blood flow ranged from 47 ml/100 g/min to 63 ml/100 g/min, with a mean of 56 ml/100 g/min. In the injured nerves, blood flow was most depressed at sites closest to the laceration, and increased consistently and progressively at sites distant from the injury in both directions.(ABSTRACT TRUNCATED AT 250 WORDS)


Subject(s)
Lasers , Peripheral Nerve Injuries , Peripheral Nerves/blood supply , Female , Humans , Male , Nerve Compression Syndromes/physiopathology , Regional Blood Flow , Ulnar Nerve/injuries
SELECTION OF CITATIONS
SEARCH DETAIL