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1.
Chemosphere ; 335: 139010, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37236281

ABSTRACT

Heavy metals (HMs) and metalloids (Ms) such as arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) represent serious environmental threats due to their wide abundance and high toxicity. Contamination of water and soils by HMs and Ms from natural or anthropogenic sources is of great concern in agricultural production due to their toxic effects on plants, adversely affecting food safety and plant growth. The uptake of HMs and Ms by Phaseolus vulgaris L. plants depends on several factors including soil properties such as pH, phosphate, and organic matter. High concentrations of HMs and Ms could be toxic to plants due to the increased generation of reactive oxygen species (ROS) such as (O2•-), (•OH), (H2O2), and (1O2), and oxidative stress due to an imbalance between ROS generation and antioxidant enzyme activity. To minimize the effects of ROS, plants have developed a complex defense mechanism based on the activity of antioxidant enzymes such as SOD, CAT, GPX, and phytohormones, especially salicylic acid (SA) that can reduce the toxicity of HMs and Ms. This review focuses on evaluating the accumulation and translocation of As, Cd, Hg, and Pb in Phaseolus vulgaris L. plants and on their possible effects on the growth of Phaseolus vulgaris L. in soil contaminated with these elements. The factors that affect the uptake of HMs and Ms by bean plants, and the defense mechanisms under oxidative stress caused by the presence of As, Cd, Hg, and Pb are also discussed. Furthermore, future research on mitigating HMs and Ms toxicity in Phaseolus vulgaris L. plants is highlighted.


Subject(s)
Arsenic , Mercury , Metalloids , Metals, Heavy , Phaseolus , Soil Pollutants , Cadmium/toxicity , Reactive Oxygen Species/pharmacology , Antioxidants/pharmacology , Hydrogen Peroxide/pharmacology , Lead/pharmacology , Soil Pollutants/analysis , Metals, Heavy/analysis , Arsenic/analysis , Mercury/toxicity , Plants , Soil/chemistry
2.
Clin Transl Oncol ; 21(4): 519-533, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30311145

ABSTRACT

PURPOSE: Current cancer treatment options include surgical intervention, radiotherapy, and chemotherapy. The quality of the provision of each of them and their effective coordination determines the results in terms of benefit/risk. Regarding the radiation oncology treatments, there are not stabilised quality indicators to be used to perform control and continuous improvement processes for healthcare services. Therefore, the Spanish Society of Radiation Oncology has undertaken a comprehensive project to establish quality indicators for use with the information systems available in most Spanish healthcare services. METHODS: A two-round Delphi study examines consensus of several possible quality indicators (n = 28) in daily practice. These indicators were defined after a bibliographic search and the assessment by radiation oncology specialists (n = 8). They included aspects regarding treatment equipment, patient preparation, treatment, and follow-up processes and were divided in structure, process, and outcome indicators. RESULTS: After the evaluation of the defined quality indicators (n = 28) by an expert panel (38 radiation oncologist), 26 indicators achieved consensus in terms of agreement with the statement. Two quality indicators did not achieve consensus. CONCLUSIONS: There is a high degree of consensus in Spanish Radiation Oncology specialists on which indicators in routine clinical practice can best measure quality. These indicators can be used to classify services based on several parameters (patients, equipments, complexity of the techniques used, and scientific research). Furthermore, these indicators allow assess our current situation and set improvements' objectives.


Subject(s)
Quality Assurance, Health Care/standards , Quality Indicators, Health Care/standards , Radiation Oncology/standards , Consensus , Delphi Technique , Humans , Neoplasms/radiotherapy , Radiation Oncology/organization & administration , Spain
3.
Chem Commun (Camb) ; 54(16): 1952-1955, 2018 Feb 20.
Article in English | MEDLINE | ID: mdl-29323379

ABSTRACT

Metabolomic profiles were explored to understand environmental and taxonomic influences on the metabolism of two congeneric zoanthids, Palythoa caribaeorum and P. variabilis, collected across distinct geographical ranges. Integrated mass spectrometry data suggested the major influence of geographical location on chemical divergence when compared to species differentiation.


Subject(s)
Anthozoa/chemistry , Anthozoa/metabolism , Metabolomics , Animals , Brazil , Geography , Mass Spectrometry , Molecular Structure , Species Specificity
4.
Clin Transl Radiat Oncol ; 2: 19-22, 2017 Feb.
Article in English | MEDLINE | ID: mdl-29657995

ABSTRACT

Aggressive hemangiomas invade the spinal canal and/or paravertebral space and may cause cord compression and neurological symptoms. Radiation therapy was recognized as an effective strategy for the treatment of aggressive hemangiomas. Here, it is reported the first case of aggressive vertebral hemangioma treated by a combination of intraoperative radiation therapy and kyphoplasty (Kypho-IORT).

5.
Tex Heart Inst J ; 27(4): 356-60, 2000.
Article in English | MEDLINE | ID: mdl-11198308

ABSTRACT

From January 1991 through December 1999, 5 consecutive patients who were infected with human immunodeficiency virus presented in need of cardiac surgery. All were men; the median age was 44 years. Two of them presented with mitral and aortic infectious valve endocarditis, 1 with tricuspid endocarditis, 1 with prosthetic valve endocarditis, and 1 with pericarditis and pericardial tamponade. Under cardiopulmonary bypass, the 4 patients with endocarditis underwent these procedures: mitral and aortic valve replacement (2), tricuspid valve replacement (1), and aortic valve replacement (reoperation) and concomitant repair of a mycotic ascending aortic aneurysm (1). In the patient who had pericardial effusion, subxifoid pericardiostomy and drainage were performed, and a pericardial window was created. There was no intraoperative mortality. The patient with pericardial effusion died 8 days after surgery; he was in septic shock and had multiple organ failure. Two deaths occurred at 2 and 63 months, due to hemoptysis and sudden death, respectively. The 2 patients who underwent double valve replacement are alive and in good condition after a median follow-up of 71 months. Cardiac surgery is indicated in selected patients infected by the human immunodeficiency virus. These patients are frequently drug abusers or homosexual. Valvular endocarditis is the most common finding. Hospital morbidity and mortality rates are higher than usual in this group of patients.


Subject(s)
Cardiac Surgical Procedures , Endocarditis, Bacterial/surgery , HIV Infections/complications , HIV-1 , Pericarditis/surgery , AIDS-Related Opportunistic Infections/surgery , Adult , Aortic Aneurysm/complications , Aortic Aneurysm/surgery , Endocarditis, Bacterial/complications , Humans , Middle Aged , Pericarditis/complications
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