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4.
Antimicrob Agents Chemother ; 56(6): 3417-9, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22391532

ABSTRACT

We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery. In the first episode of candidemia, an echinocandin-susceptible Candida glabrata strain was isolated, and the patient was treated with caspofungin. The isolates from the later episodes showed resistance to echinocandins. Analysis of the HS1 region of the FKS2 gene showed the amino acid substitution S663P. Microsatellite analysis demonstrated a strong genetic relationship between the isolates.


Subject(s)
Antifungal Agents/therapeutic use , Candida glabrata/pathogenicity , Candidemia/microbiology , Echinocandins/therapeutic use , Fungal Proteins/genetics , Aged , Candida glabrata/genetics , Candidemia/drug therapy , Caspofungin , Humans , Lipopeptides , Male , Mutation
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