ABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Early Diagnosis , Tomography, Emission-Computed, Single-Photon/methods , Renal Dialysis , Calciphylaxis/diagnostic imaging , Calciphylaxis/etiology , Renal Insufficiency, Chronic/complications , Hyperparathyroidism/complications , Calciphylaxis/therapy , Diagnostic Imaging/methods , Disease Management , Disease ProgressionABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Erythrocytes/physiology , Liver Cirrhosis/complications , Liver Cirrhosis/diagnostic imaging , Liver Cirrhosis/pathology , Liver/diagnostic imaging , Liver/surgery , Radionuclide Imaging/methods , Splenosis/complications , Splenosis/diagnostic imaging , Splenosis/pathology , Liver TransplantationSubject(s)
Erythrocytes/physiology , Liver Cirrhosis , Liver , Radionuclide Imaging/methods , Splenosis , Aged , Humans , Liver/diagnostic imaging , Liver/surgery , Liver Cirrhosis/complications , Liver Cirrhosis/diagnostic imaging , Liver Cirrhosis/pathology , Liver Cirrhosis/surgery , Liver Transplantation , Male , Splenosis/complications , Splenosis/diagnostic imaging , Splenosis/pathologyABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Incidental Findings , Cystocele/diagnostic imaging , Radionuclide ImagingABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Vasculitis/diagnostic imaging , Vasculitis/drug therapy , Fluorodeoxyglucose F18/administration & dosage , Fever of Unknown Origin/complications , Positron Emission Tomography Computed Tomography , Fever of Unknown Origin/etiology , Asthenia/etiology , Adrenal Cortex Hormones/administration & dosageSubject(s)
Fever of Unknown Origin/etiology , Positron Emission Tomography Computed Tomography , Vasculitis/diagnostic imaging , Adrenal Cortex Hormones/therapeutic use , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Humans , Male , Middle Aged , Radiopharmaceuticals , Sensitivity and Specificity , Vasculitis/complications , Vasculitis/drug therapyABSTRACT
We present a 44-year-old woman with scapular and pelvic muscle weakness, joint inflammation, and fever. Bone scintigraphy showed high uptake in proximal regions of upper and lower limbs, suspecting inflammatory myopathy and polyarticular damage. These features were the clue to request other complementary tests such as anti-aminoacyl-tRNA-synthetase antibodies and chest CT, which showed interstitial lung disease, defining an antisynthetase syndrome. Therefore, BS allows an earlier diagnosis of inflammatory muscle disease and to identify the optimal site for muscle biopsy. BS is an important step to reach a prompt diagnosis of antisynthetase syndrome for establishing an early treatment.
Subject(s)
Bone and Bones/diagnostic imaging , Myositis/diagnostic imaging , Radionuclide Imaging , Adult , Antigens, CD , Antigens, Differentiation, T-Lymphocyte , Diphosphonates , Early Diagnosis , Female , Humans , Lectins, C-Type , Organotechnetium Compounds , Radiopharmaceuticals , Tomography, X-Ray ComputedABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Lymphoscintigraphy , Tomography, Emission-Computed, Single-Photon , Breast Neoplasms , Drainage , Axilla , Extravasation of Diagnostic and Therapeutic Materials/surgery , Neoplasm Recurrence, Local/diagnosisABSTRACT
The development of superparamagnetic iron oxide nanoparticle (SPION)-based diagnostic and therapeutic nanosystems holds a promise of revolutionizing biomedicine, helping to solve important unmet clinical needs. Such potential will only be fulfilled if appropriate methods for SPION production and for their subsequent tailoring to specific applications are established, something that remains challenging. Here, we report a simple and low cost method to fabricate structurally and colloidally ultrastable, water soluble SPIONs. We used thermal decomposition to produce SPIONs of the highest quality, which were then thinly coated with an amine-silane derivative by ligand exchange, conferring hydrophilicity and great structural stability on the nanoparticles. Subsequent partial covalent occupancy of surface amine groups with polyethyleneglycol (PEG) was carried out to give them excellent colloidal stability, whilst still leaving reactive anchoring points for further functionalization. The correct composition and physicochemical properties of our PEGylated SPIONs and their precursors were confirmed using a broad range of analytical techniques, and we also demonstrated the biocompatible character of the resulting nanoparticles, as well as their suitability as T2 MRI contrast agents in vivo. Finally, using a near infra-red fluorophore, we also confirmed that these SPIONs are amenable to further tuning, to adapt them to a wide range of applications or to optimize their performance in particular settings. In summary, our work provides a novel and robust method for the production of SPIONs that can be used as a tunable platform for the development of smart diagnostic and therapeutic nanosystems.
Subject(s)
Amines/chemistry , Contrast Media , Magnetic Resonance Imaging , Magnetite Nanoparticles/chemistry , Silanes/chemistry , Animals , Female , Ferric Compounds , Hep G2 Cells , Humans , Mice, Inbred BALB CSubject(s)
Carcinoma, Hepatocellular/diagnostic imaging , Erythrocytes/diagnostic imaging , Liver Neoplasms/diagnostic imaging , Peritoneum/diagnostic imaging , Splenosis/diagnostic imaging , Hepatitis C, Chronic/complications , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/diagnostic imaging , Male , Middle Aged , Positron-Emission Tomography , Radiopharmaceuticals , TechnetiumABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Radionuclide Imaging/methods , Splenosis/complications , Splenosis , Gastrointestinal Hemorrhage/complications , Gastrointestinal Hemorrhage , Carcinoma, Hepatocellular/complications , Carcinoma, Hepatocellular , Tomography, Emission-Computed , Positron-Emission Tomography , Transplantation, Heterotopic/trends , Diagnosis, DifferentialABSTRACT
Fundamento y objetivo: Evaluar el estado funcional de la vía nigro-estriada utilizando N-ω-fluoropropil-2ß-carbometoxi-3ß-(4-Iodofenil) nortropano (FP-CIT-I-123) en pacientes con diagnóstico clínico de atrofia multisistémica (AMS) subtipo C. Pacientes y método: Se incluyen 10 pacientes con diagnóstico clínico de AMS-C y se comparan con 10 diagnosticados de temblor esencial (controles) y otros 10 con enfermedad de Parkinson (EP). Los estudios son valorados mediante el índice estriado/occipital (E/O), calculando la validez diagnóstica del procedimiento mediante curvas ROC. Resultados: El valor medio (DE) del índice E/O fue de 1,48 (0,23), 1,59 (0,17) y 1,22 (0,16), correspondientes, respectivamente, a AMS-C, controles (p=0,25) y EP (p=0,00). Curva ROC: Az: 0,650; sensibilidad: 0,50; especificidad: 0,80. La correlación del estudio con FP-CIT y la clínica predominante mostró 4 pacientes con clínica parkinsoniana y estudio patológico, 4 sin clínica parkinsoniana y estudio normal, uno con clínica parkinsoniana y estudio normal, y uno sin clínica parkinsoniana y estudio patológico. Conclusiones: El estudio con FP-CIT no permite descartar totalmente la existencia de una AMS-C. Desde el punto de vista funcional, no siempre parece existir congruencia entre el estado de la vía nigro-estriada y la existencia de parkinsonismo (AU)
Background and objective: To assess the functional state of nigro-striatal pathway using FP-CIT-I-123 in patients with clinical diagnosis of Multiple System Atrophy (MSA) subtype C. Patients and methods: We included 10 patients with a clinical diagnosis of MSA-C and compared them with 10 patients diagnosed with essential tremor (controls) and 10 with Parkinson Disease (PD). The studies are evaluated by the striatum/occipital index (S/O). We calculated the diagnostic validity of the procedure by ROC curve analysis. Results: The average value of the S/O index showed a mean of 1.48 (0.23), 1.59 (0.17) and 1.22 (0.16) respectively for MSA-C, control group (p=0.25) and PD (p=0.00). ROC curve analysis: Az: 0.650; sensitivity: 0.50; specificity: 0.80. The comparison between the results of FP-CIT and clinical manifestations showed: 4 patients with parkinsonism (PK) and pathological study; 4 without PK and normal study; 1 with PK and normal study and 1 without PK and pathological study. Conclusions: FP-CIT study does not exclude completely the existence of an MSA-C. From a functional point of view, there does not always seem to be a consistency between the state of the nigro-striatal pathway and the existence of parkinsonism (AU)
Subject(s)
Humans , Olivopontocerebellar Atrophies/physiopathology , Tomography, Emission-Computed, Single-Photon/methods , Dopamine Plasma Membrane Transport Proteins/analysis , Corpus Striatum/physiopathologyABSTRACT
BACKGROUND AND OBJECTIVE: To assess the functional state of nigro-striatal pathway using FP-CIT-I-123 in patients with clinical diagnosis of Multiple System Atrophy (MSA) subtype C. PATIENTS AND METHODS: We included 10 patients with a clinical diagnosis of MSA-C and compared them with 10 patients diagnosed with essential tremor (controls) and 10 with Parkinson Disease (PD). The studies are evaluated by the striatum/occipital index (S/O). We calculated the diagnostic validity of the procedure by ROC curve analysis. RESULTS: The average value of the S/O index showed a mean of 1.48 (0.23), 1.59 (0.17) and 1.22 (0.16) respectively for MSA-C, control group (p=0.25) and PD (p=0.00). ROC curve analysis: Az: 0.650; sensitivity: 0.50; specificity: 0.80. The comparison between the results of FP-CIT and clinical manifestations showed: 4 patients with parkinsonism (PK) and pathological study; 4 without PK and normal study; 1 with PK and normal study and 1 without PK and pathological study. CONCLUSIONS: FP-CIT study does not exclude completely the existence of an MSA-C. From a functional point of view, there does not always seem to be a consistency between the state of the nigro-striatal pathway and the existence of parkinsonism.
